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| | MTES_1323 | Uncharacterized conserved protein. (204 aa) |
| | coaE | dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (200 aa) |
| | pgk | 3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (404 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (262 aa) |
| | pgl | 6-phosphogluconolactonase/Glucosamine-6- phosphate isomerase/deaminase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (263 aa) |
| | zwf | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (516 aa) |
| | pgiA | Glucose-6-phosphate isomerase; Belongs to the GPI family. (541 aa) |
| | tal2 | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (373 aa) |
| | tktA1 | Transketolase; Belongs to the transketolase family. (709 aa) |
| | MTES_3614 | Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. (371 aa) |
| | MTES_3613 | Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit. (333 aa) |
| | MTES_3612 | Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component. (515 aa) |
| | MTES_3608 | Gentisate 1,2-dioxygenase. (366 aa) |
| | pyk | Pyruvate kinase; Belongs to the pyruvate kinase family. (481 aa) |
| | MTES_3548 | Pentose-5-phosphate-3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (223 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (307 aa) |
| | pyrF | Orotidine-5'-phosphate decarboxylase; Belongs to the OMP decarboxylase family. Type 2 subfamily. (286 aa) |
| | carB | Carbamoylphosphate synthase large subunit; Belongs to the CarB family. (1095 aa) |
| | carA | Carbamoylphosphate synthase small subunit; Belongs to the CarA family. (412 aa) |
| | MTES_3538 | Hypothetical protein. (158 aa) |
| | pyrC | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (440 aa) |
| | pyrB | Aspartate carbamoyltransferase, catalytic chain; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (322 aa) |
| | relA | Guanosine polyphosphate pyrophosphohydrolase/synthetase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (750 aa) |
| | pdxT | Predicted glutamine amidotransferase; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (197 aa) |
| | pdxS | Pyridoxine biosynthesis enzyme; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (294 aa) |
| | MTES_3498 | Pyridoxal/pyridoxine/pyridoxamine kinase; Belongs to the pyridoxine kinase family. (284 aa) |
| | MTES_3496 | Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolase. (188 aa) |
| | dxs | Deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (648 aa) |
| | dut | dUTPase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (151 aa) |
| | MTES_3462 | Uncharacterized conserved protein. (232 aa) |
| | MTES_3457 | Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component. (570 aa) |
| | aceE | Pyruvate dehydrogenase complex, dehydrogenase (E1) component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (908 aa) |
| | dgt | dGTP triphosphohydrolase; Belongs to the dGTPase family. Type 2 subfamily. (440 aa) |
| | MTES_3381 | Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolase. (115 aa) |
| | MTES_3360 | Hypothetical protein. (351 aa) |
| | nadD | Nicotinic acid mononucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (198 aa) |
| | ndk | Nucleoside diphosphate kinase. (138 aa) |
| | tesB | acyl-CoA thioesterase. (289 aa) |
| | MTES_3299 | Adenylate kinase. (197 aa) |
| | MTES_3278 | CDP-diglyceride synthetase; Belongs to the CDS family. (350 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (239 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (165 aa) |
| | thiL | Thiamine monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (334 aa) |
| | gpsA | Glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (380 aa) |
| | MTES_3233 | 1-acyl-sn-glycerol-3-phosphate acyltransferase. (245 aa) |
| | MTES_3182 | NTP pyrophosphohydrolase including oxidative damage repair enzyme. (173 aa) |
| | MTES_3179 | Archaeal fructose-1,6-bisphosphatase. (272 aa) |
| | MTES_3159 | Xanthosine triphosphate pyrophosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (198 aa) |
| | MTES_3156 | Nicotinic acid phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (444 aa) |
| | idi | Isopentenyldiphosphate isomerase; Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). (183 aa) |
| | MTES_3122 | NTP pyrophosphohydrolase containing a Zn-finger, probably nucleic-acid-binding. (301 aa) |
| | MTES_3099 | Predicted integral membrane protein. (407 aa) |
| | nadA | Quinolinate synthase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (443 aa) |
| | MTES_3060 | Aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (511 aa) |
| | nadC | Nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family. (285 aa) |
| | fba | Fructose/tagatose bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (342 aa) |
| | ispH | Penicillin tolerance protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (353 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (426 aa) |
| | MTES_2986 | Predicted pyrophosphatase. (217 aa) |
| | gnd-2 | 6-phosphogluconate dehydrogenase; Belongs to the 6-phosphogluconate dehydrogenase family. (531 aa) |
| | psrA | Phosphoribosylpyrophosphate synthetase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (344 aa) |
| | glmU | N-acetylglucosamine-1-phosphate uridyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (482 aa) |
| | ispE | 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (308 aa) |
| | hydA | Dihydroorotase. (480 aa) |
| | MTES_2887 | Archaeal fructose-1,6-bisphosphatase. (278 aa) |
| | nrdF | Ribonucleotide reductase, beta subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (324 aa) |
| | MTES_2810 | Uncharacterized protein conserved in bacteria. (148 aa) |
| | coaBC | Phosphopantothenoylcysteine synthetase/decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (400 aa) |
| | ispF | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D- erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C- methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF). (387 aa) |
| | gpmA | Phosphoglycerate mutase 1; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (248 aa) |
| | MTES_2681 | Amidase. (192 aa) |
| | deoC | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (250 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (224 aa) |
| | acsA | Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (655 aa) |
| | MTES_2658 | Predicted phosphohydrolase. (307 aa) |
| | tdk | Thymidine kinase. (201 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (410 aa) |
| | MTES_2624 | Phosphotransacetylase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (714 aa) |
| | gnd | Predicted 6-phosphogluconate dehydrogenase. (353 aa) |
| | moaA | Molybdenum cofactor biosynthesis enzyme; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (406 aa) |
| | MTES_2501 | Molybdopterin biosynthesis enzyme; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (407 aa) |
| | moaC | Molybdenum cofactor biosynthesis enzyme. (191 aa) |
| | MTES_2499 | Hypothetical protein. (78 aa) |
| | MTES_2498 | Molybdopterin converting factor, large subunit. (142 aa) |
| | MTES_2497 | Molybdopterin biosynthesis enzyme. (160 aa) |
| | MTES_2427 | Nicotinamide mononucleotide adenylyltransferase. (364 aa) |
| | MTES_2390 | Archaeal fructose-1,6-bisphosphatase; Belongs to the inositol monophosphatase superfamily. (269 aa) |
| | MTES_2362 | Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase. (564 aa) |
| | upp | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (210 aa) |
| | nadE | NAD synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (685 aa) |
| | MTES_2267 | 3-hexulose-6-phosphate synthase. (750 aa) |
| | MTES_2220 | dGTP triphosphohydrolase; Belongs to the dGTPase family. Type 2 subfamily. (507 aa) |
| | araA | L-arabinose isomerase; Catalyzes the conversion of L-arabinose to L-ribulose. (503 aa) |
| | MTES_2196 | Hypothetical protein. (1027 aa) |
| | MTES_2180 | NTP pyrophosphohydrolase including oxidative damage repair enzyme. (192 aa) |
| | pyrG | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (566 aa) |
| | ppnK | Predicted sugar kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (306 aa) |
| | MTES_2111 | Sphingosine kinase and enzyme. (429 aa) |
| | MTES_2014 | Triosephosphate isomerase. (255 aa) |
| | MTES_1946 | Uncharacterized conserved protein. (250 aa) |
| | MTES_1932 | Hypothetical protein. (1154 aa) |
| | MTES_1925 | Predicted NTP pyrophosphohydrolase. (158 aa) |
| | thiM | Hydroxyethylthiazole kinase, sugar kinase family; Catalyzes the phosphorylation of the hydroxyl group of 4- methyl-5-beta-hydroxyethylthiazole (THZ); Belongs to the Thz kinase family. (273 aa) |
| | thiE | Thiamine monophosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (211 aa) |
| | MTES_1890 | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. (484 aa) |
| | fbiD | Uncharacterized conserved protein; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor. (212 aa) |
| | MTES_1873 | Uncharacterized conserved protein. (321 aa) |
| | purU | Formyltetrahydrofolate hydrolase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (687 aa) |
| | pyrE | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (192 aa) |
| | MTES_1791 | Lactoylglutathione lyase. (126 aa) |
| | MTES_1788 | Glucose-6-phosphate 1-dehydrogenase. (456 aa) |
| | dcd | Deoxycytidine deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (201 aa) |
| | MTES_1668 | Lactoylglutathione lyase. (179 aa) |
| | pdhC | Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component. (444 aa) |
| | pdhB | Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit. (325 aa) |
| | pdhA | Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. (376 aa) |
| | purB | Adenylosuccinate lyase. (459 aa) |
| | pdxH | Pyridoxamine-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (213 aa) |
| | MTES_1583 | Uncharacterized protein conserved in bacteria. (151 aa) |
| | MTES_1485 | Predicted membrane protein. (305 aa) |
| | purA | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (428 aa) |
| | MTES_1446 | 3-carboxymuconate cyclase. (409 aa) |
| | purL | Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL an [...] (790 aa) |
| | fdhD | Uncharacterized protein; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (296 aa) |
| | MTES_1400 | Molybdopterin biosynthesis enzyme; Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. Belongs to the MoeA family. (396 aa) |
| | MTES_1399 | Molybdopterin-guanine dinucleotide biosynthesis protein A. (294 aa) |
| | apt | Adenine/guanine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (174 aa) |
| | pgi | Glucose-6-phosphate isomerase; Belongs to the GPI family. (571 aa) |
| | MTES_0010 | NTP pyrophosphohydrolase including oxidative damage repair enzyme. (238 aa) |
| | MTES_0023 | Lactoylglutathione lyase. (124 aa) |
| | pyrD | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (341 aa) |
| | plsC | 1-acyl-sn-glycerol-3-phosphate acyltransferase. (237 aa) |
| | MTES_0119 | Transcriptional regulator/sugar kinase. (311 aa) |
| | MTES_0132 | GMP synthase - Glutamine amidotransferase domain. (251 aa) |
| | nnrE | Uncharacterized conserved protein; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX; Belongs to the NnrE/AIBP family. (256 aa) |
| | pdhA-2 | Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (365 aa) |
| | MTES_0220 | Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (330 aa) |
| | MTES_0221 | Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component. (396 aa) |
| | cmk | Cytidylate kinase. (257 aa) |
| | MTES_0308 | Uncharacterized protein; Belongs to the CinA family. (175 aa) |
| | MTES_0309 | Phosphatidylglycerophosphate synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (195 aa) |
| | MTES_0314 | NTP pyrophosphohydrolase including oxidative damage repair enzyme. (178 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (269 aa) |
| | pfkA | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (342 aa) |
| | MTES_0363 | FAD synthase; Belongs to the ribF family. (314 aa) |
| | MTES_0367 | Predicted GTPase. (159 aa) |
| | ispG | Enzyme; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (380 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (360 aa) |
| | plsC-2 | 1-acyl-sn-glycerol-3-phosphate acyltransferase. (249 aa) |
| | MTES_0399 | Glycerol-3-phosphate dehydrogenase. (572 aa) |
| | glpk | Glycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (503 aa) |
| | atpC | F0F1-type ATP synthase, epsilon subunit. (86 aa) |
| | atpD | F0F1-type ATP synthase, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (482 aa) |
| | atpG | F0F1-type ATP synthase, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (299 aa) |
| | atpA | F0F1-type ATP synthase, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (543 aa) |
| | atpH | F0F1-type ATP synthase, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (262 aa) |
| | atpF | F0F1-type ATP synthase, subunit b; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (192 aa) |
| | atpE | F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K. (48 aa) |
| | atpB | F0F1-type ATP synthase, subunit a; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (310 aa) |
| | MTES_0458 | Predicted integral membrane protein. (440 aa) |
| | MTES_0483 | Predicted phosphoribosyltransferase. (161 aa) |
| | nnrD | Predicted sugar kinase; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. (302 aa) |
| | guaB | IMP dehydrogenase/GMP reductase. (484 aa) |
| | MTES_0578 | Phosphoheptose isomerase. (193 aa) |
| | purE | Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (171 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (385 aa) |
| | MTES_0596 | Nucleotide-binding protein; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (215 aa) |
| | add | Adenosine deaminase. (376 aa) |
| | MTES_0645 | GTP cyclohydrolase I. (200 aa) |
| | MTES_0664 | Hypothetical protein. (272 aa) |
| | folD | 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (294 aa) |
| | purH-2 | AICAR transformylase/IMP cyclohydrolase PurH. (536 aa) |
| | purN | Folate-dependent phosphoribosylglycinamide formyltransferase PurN; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (207 aa) |
| | MTES_0706 | Uncharacterized conserved protein. (211 aa) |
| | purA-2 | Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (552 aa) |
| | MTES_0774 | Predicted enzyme. (122 aa) |
| | guaA | GMP synthase, PP-ATPase domain/subunit; Catalyzes the synthesis of GMP from XMP. (526 aa) |
| | guaB-2 | IMP dehydrogenase/GMP reductase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (500 aa) |
| | coaA | Panthothenate kinase. (314 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (198 aa) |
| | MTES_1003 | UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase. (157 aa) |
| | MTES_1007 | GMP synthase - Glutamine amidotransferase domain. (242 aa) |
| | MTES_1015 | Uncharacterized protein conserved in bacteria. (225 aa) |
| | ldh | Malate/lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (317 aa) |
| | cls | Phosphatidylserine/phosphatidylglycerophosphate/ cardiolipin synthase; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol; Belongs to the phospholipase D family. Cardiolipin synthase subfamily. (488 aa) |
| | folE | GTP cyclohydrolase I. (195 aa) |
| | MTES_1081 | Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (183 aa) |
| | MTES_1099 | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (415 aa) |
| | MTES_1126 | Deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (229 aa) |
| | MTES_1131 | Alpha-glucosidase, family 31 of glycosyl hydrolase. (965 aa) |
| | purF | Glutamine phosphoribosylpyrophosphate amidotransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (491 aa) |
| | purM | Phosphoribosylaminoimidazole (AIR) synthetase. (380 aa) |
| | purD | Phosphoribosylamine-glycine ligase; Belongs to the GARS family. (423 aa) |
| | purC | Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; Belongs to the SAICAR synthetase family. (327 aa) |
| | MTES_1220 | Predicted glycosyltransferase. (172 aa) |
| | purS | Phosphoribosylformylglycinamidine (FGAM) synthase, PurS component; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and i [...] (82 aa) |
| | purQ | Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with [...] (235 aa) |
| | nnrD-2 | Predicted sugar kinase; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. (277 aa) |
| | MTES_1291 | Fructose-2,6-bisphosphatase; Belongs to the phosphoglycerate mutase family. (240 aa) |
| | MTES_1319 | Pyridoxamine-phosphate oxidase. (204 aa) |
| | MTES_1326 | Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase. (410 aa) |
