STRINGSTRING
CXXC1 CXXC1 FERMT1 FERMT1 VSIG2 VSIG2 TP73 TP73 TNF TNF FBXO28 FBXO28 F6Y7H8_HORSE F6Y7H8_HORSE LIN7A LIN7A ACTL8 ACTL8 ACTBL2 ACTBL2 NRIP1 NRIP1 DDI1 DDI1 RGS1 RGS1 RPA2 RPA2 TMEM104 TMEM104 CLDN4 CLDN4 MUC13 MUC13 RNF19A RNF19A FBXL12 FBXL12 PTPN3 PTPN3 IL10 IL10 CD4 CD4 OCLN OCLN LAMB1 LAMB1 CYB5R1 CYB5R1 TLR4 TLR4 TRABD2A TRABD2A POLR1A POLR1A PPP1R14D PPP1R14D TRMO TRMO MFSD11 MFSD11 EDEM2 EDEM2 PRDM10 PRDM10 TMBIM1 TMBIM1 NOP2 NOP2 TMC4 TMC4 STX12 STX12 LOC106780847 LOC106780847 WDR55 WDR55 ERAL1 ERAL1 POF1B POF1B DHRS3 DHRS3 ZG16 ZG16 LOC100058884 LOC100058884 ITGB7 ITGB7 DROSHA DROSHA TMEM54 TMEM54 PYY PYY LOC100069985 LOC100069985 NLRP3 NLRP3 MARS1 MARS1 F6VRB2_HORSE F6VRB2_HORSE SLC19A2 SLC19A2 ACTB ACTB HNF1B HNF1B TRAPPC11 TRAPPC11 KRT24 KRT24 SLC26A3 SLC26A3 GAL GAL TOR4A TOR4A NLRP12 NLRP12 TLR2 TLR2 DUS1L DUS1L ACTG1 ACTG1 JAK1 JAK1 NLRX1 NLRX1 GNPNAT1 GNPNAT1 SNRPF SNRPF ARID5B ARID5B CFL1 CFL1 TMIGD1 TMIGD1 SETDB2-2 SETDB2-2 FA2H FA2H FAM83E FAM83E TMEFF2 TMEFF2 PLCD3 PLCD3 CLDN1 CLDN1 SPDEF SPDEF CCHCR1 CCHCR1 FAU FAU APP APP WNT11 WNT11 NPRL2 NPRL2 PTTG1IP PTTG1IP PCDH18 PCDH18 LOC100072001 LOC100072001 F6W6J0_HORSE F6W6J0_HORSE LPCAT4 LPCAT4 RAB25 RAB25 RSAD1 RSAD1 RPL4 RPL4 CXCR3 CXCR3 PDZD3 PDZD3 GSDMB GSDMB NOP14 NOP14 MEPCE MEPCE INSL5 INSL5 SNRNP25 SNRNP25 CA7 CA7 PLA2G3 PLA2G3 SLC16A9 SLC16A9 TCF7L2 TCF7L2 LOC111772308 LOC111772308 LOC111771820 LOC111771820 CLDN3 CLDN3 ENSECAP00000026030 ENSECAP00000026030 AQP8 AQP8 GALNT12 GALNT12 LMO2 LMO2 ENSECAP00000027821 ENSECAP00000027821 OSMR OSMR CCL24 CCL24 ITPKB ITPKB POLR1A-2 POLR1A-2 ENSECAP00000029452 ENSECAP00000029452 SIRT4 SIRT4 LOC111771996 LOC111771996 HHLA2 HHLA2 NOXO1 NOXO1 TLR3 TLR3 IGF1 IGF1 LOC111771935 LOC111771935 ZNF469 ZNF469 FAM3D FAM3D D2HGDH D2HGDH EIF4EBP1 EIF4EBP1 LOC102149794 LOC102149794 DEF8 DEF8 STAT3 STAT3 ENSECAP00000036381 ENSECAP00000036381 RSC1A1 RSC1A1 ETV4 ETV4 BEST2 BEST2 TMEM45B TMEM45B PFDN1 PFDN1 CLDN8 CLDN8 CHP2 CHP2 CRADD CRADD LOC100069872 LOC100069872 AOC1 AOC1 ENSECAP00000041316 ENSECAP00000041316 LRG1 LRG1 TRABD2B TRABD2B RNF111 RNF111 LOC100058771 LOC100058771 B2M B2M ZNF217 ZNF217 MS4A12 MS4A12 ABCF2 ABCF2 LOC100071927 LOC100071927 COLCA2 COLCA2 LOC111771136 LOC111771136 ELP6 ELP6 GPX2 GPX2 ENSECAP00000055121 ENSECAP00000055121
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CXXC1CXXC finger protein 1. (664 aa)
FERMT1Fermitin family member 1. (677 aa)
VSIG2V-set and immunoglobulin domain containing 2. (444 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (655 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa)
FBXO28F-box protein 28. (368 aa)
F6Y7H8_HORSEUncharacterized protein. (126 aa)
LIN7AProtein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (233 aa)
ACTL8Actin like 8; Belongs to the actin family. (366 aa)
ACTBL2Actin beta like 2. (376 aa)
NRIP1Nuclear receptor interacting protein 1. (1155 aa)
DDI1DNA damage inducible 1 homolog 1. (400 aa)
RGS1Regulator of G-protein signaling 1; Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the N-formylpeptide chemoattractant receptors and leukotriene receptors. Inhibits B cell chemotaxis toward CXCL12 (By similarity). Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (By similarity). (209 aa)
RPA2Replication protein A2. (278 aa)
TMEM104Transmembrane protein 104. (626 aa)
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
MUC13Uncharacterized protein. (466 aa)
RNF19ARBR-type E3 ubiquitin transferase. (838 aa)
FBXL12F-box and leucine rich repeat protein 12. (332 aa)
PTPN3Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (913 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (249 aa)
CD4CD4 molecule. (460 aa)
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (520 aa)
LAMB1Laminin subunit beta 1. (1834 aa)
CYB5R1NADH-cytochrome b5 reductase; Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (332 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (843 aa)
TRABD2ATraB domain containing 2A. (508 aa)
POLR1ADNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1720 aa)
PPP1R14DProtein phosphatase 1 regulatory inhibitor subunit 14D. (145 aa)
TRMOtRNA methyltransferase O. (441 aa)
MFSD11Major facilitator superfamily domain containing 11. (449 aa)
EDEM2alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (576 aa)
PRDM10PR/SET domain 10. (1127 aa)
TMBIM1Transmembrane BAX inhibitor motif containing 1; Belongs to the BI1 family. (305 aa)
NOP2NOP2 nucleolar protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (814 aa)
TMC4Transmembrane channel-like protein. (712 aa)
STX12Syntaxin 12; Belongs to the syntaxin family. (276 aa)
LOC106780847Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (447 aa)
WDR55WD repeat-containing protein 55; Nucleolar protein that acts as a modulator of rRNA synthesis. Plays a central role during organogenesis. Belongs to the WD repeat WDR55 family. (380 aa)
ERAL1Era like 12S mitochondrial rRNA chaperone 1. (437 aa)
POF1BPOF1B actin binding protein. (589 aa)
DHRS3Dehydrogenase/reductase 3. (381 aa)
ZG16Zymogen granule protein 16. (165 aa)
LOC100058884Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (456 aa)
ITGB7Integrin beta; Belongs to the integrin beta chain family. (798 aa)
DROSHADrosha ribonuclease III. (1374 aa)
TMEM54Transmembrane protein 54. (223 aa)
PYYPeptide YY. (252 aa)
LOC100069985Uncharacterized protein. (456 aa)
NLRP3NLR family pyrin domain containing 3. (1031 aa)
MARS1Methionyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (920 aa)
F6VRB2_HORSEUncharacterized protein. (425 aa)
SLC19A2Solute carrier family 19 member 2. (498 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (377 aa)
HNF1BHNF1 homeobox B. (558 aa)
TRAPPC11Trafficking protein particle complex 11. (1161 aa)
KRT24Keratin 24; Belongs to the intermediate filament family. (506 aa)
SLC26A3Chloride anion exchanger; Chloride/bicarbonate exchanger. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (759 aa)
GALGalanin and GMAP prepropeptide. (123 aa)
TOR4ATorsin family 4 member A. (418 aa)
NLRP12NLR family pyrin domain containing 12. (1061 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
DUS1LDihydrouridine synthase 1 like. (475 aa)
ACTG1Actin gamma 1. (462 aa)
JAK1Tyrosine-protein kinase. (1141 aa)
NLRX1NLR family member X1. (975 aa)
GNPNAT1Glucosamine 6-phosphate N-acetyltransferase. (184 aa)
SNRPFSmall nuclear ribonucleoprotein polypeptide F. (86 aa)
ARID5BAT-rich interaction domain 5B. (1109 aa)
CFL1Cofilin 1; Belongs to the actin-binding proteins ADF family. (166 aa)
TMIGD1Transmembrane and immunoglobulin domain containing 1. (262 aa)
SETDB2-2SET domain bifurcated histone lysine methyltransferase 2. (704 aa)
FA2HFatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (372 aa)
FAM83EFamily with sequence similarity 83 member E. (488 aa)
TMEFF2Transmembrane protein with EGF like and two follistatin like domains 2. (374 aa)
PLCD3Phosphoinositide phospholipase C. (784 aa)
CLDN1Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
SPDEFSAM pointed domain containing ETS transcription factor. (335 aa)
CCHCR1Coiled-coil alpha-helical rod protein 1. (842 aa)
FAU40S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family. (133 aa)
APPAmyloid beta precursor protein. (811 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
NPRL2NPR2 like, GATOR1 complex subunit. (380 aa)
PTTG1IPPTTG1 interacting protein. (180 aa)
PCDH18Protocadherin 18. (1135 aa)
LOC100072001Galectin. (388 aa)
F6W6J0_HORSEGalectin. (372 aa)
LPCAT4Lysophosphatidylcholine acyltransferase 4. (517 aa)
RAB25RAB25, member RAS oncogene family. (213 aa)
RSAD1Radical S-adenosyl methionine domain-containing protein; May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen- III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L- methionine; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (440 aa)
RPL4Ribosomal protein L4. (481 aa)
CXCR3C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (369 aa)
PDZD3PDZ domain containing 3. (505 aa)
GSDMBGasdermin B. (415 aa)
NOP14NOP14 nucleolar protein. (853 aa)
MEPCEMethylphosphate capping enzyme. (687 aa)
INSL5Insulin like 5. (135 aa)
SNRNP25Small nuclear ribonucleoprotein U11/U12 subunit 25. (132 aa)
CA7Carbonic anhydrase 7; Belongs to the alpha-carbonic anhydrase family. (264 aa)
PLA2G3Phospholipase A2 group III. (513 aa)
SLC16A9Solute carrier family 16 member 9. (541 aa)
TCF7L2Transcription factor 7 like 2. (669 aa)
LOC111772308Protein POF1B. (589 aa)
LOC111771820Protein POF1B. (589 aa)
CLDN3Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
ENSECAP00000026030Uncharacterized protein; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (447 aa)
AQP8Aquaporin 8; Belongs to the MIP/aquaporin (TC 1.A.8) family. (263 aa)
GALNT12Polypeptide N-acetylgalactosaminyltransferase. (580 aa)
LMO2LIM domain only 2. (309 aa)
ENSECAP00000027821Galectin. (159 aa)
OSMROncostatin M receptor. (972 aa)
CCL24C-C motif chemokine ligand 24. (109 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (1008 aa)
POLR1A-2RNA polymerase I subunit A. (1720 aa)
ENSECAP0000002945240S ribosomal protein S30; Belongs to the eukaryotic ribosomal protein eS30 family. (62 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (356 aa)
LOC111771996DNA-directed RNA polymerase I subunit RPA1. (1720 aa)
HHLA2HERV-H LTR-associating 2. (405 aa)
NOXO1NADPH oxidase organizer 1. (388 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (979 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
LOC111771935Toll-like receptor 4. (843 aa)
ZNF469Zinc finger protein 469. (3884 aa)
FAM3DFamily with sequence similarity 3 member D. (271 aa)
D2HGDHD-2-hydroxyglutarate dehydrogenase. (559 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (210 aa)
LOC102149794Uncharacterized protein. (468 aa)
DEF8Differentially expressed in FDCP 8 homolog. (523 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
ENSECAP00000036381TIR domain-containing protein; Belongs to the Toll-like receptor family. (772 aa)
RSC1A1Regulator of solute carriers 1. (620 aa)
ETV4ETS variant 4. (485 aa)
BEST2Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. (504 aa)
TMEM45BTransmembrane protein 45B. (276 aa)
PFDN1Uncharacterized protein. (135 aa)
CLDN8Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (253 aa)
CHP2Calcineurin like EF-hand protein 2. (428 aa)
CRADDCASP2 and RIPK1 domain containing adaptor with death domain. (233 aa)
LOC100069872H15 domain-containing protein. (194 aa)
AOC1Amine oxidase. (793 aa)
ENSECAP00000041316Uncharacterized protein. (498 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (347 aa)
TRABD2BTraB domain containing 2B. (606 aa)
RNF111Ring finger protein 111. (720 aa)
LOC100058771Galectin. (383 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (125 aa)
ZNF217Zinc finger protein 217. (1051 aa)
MS4A12Uncharacterized protein. (217 aa)
ABCF2ATP binding cassette subfamily F member 2. (636 aa)
LOC100071927Galectin. (444 aa)
COLCA2Colorectal cancer associated 2. (287 aa)
LOC111771136Histone H1.0-like. (194 aa)
ELP6Elongator acetyltransferase complex subunit 6. (270 aa)
GPX2Glutathione peroxidase; Belongs to the glutathione peroxidase family. (189 aa)
ENSECAP00000055121C-type lectin domain-containing protein. (100 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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