STRINGSTRING
SMTNL1 SMTNL1 C1H14orf119 C1H14orf119 TM4SF20 TM4SF20 POF1B POF1B PEX26 PEX26 COG4 COG4 ACTB ACTB GAL GAL TLR2 TLR2 ACTG1 ACTG1 CLCA1 CLCA1 TMIGD1 TMIGD1 TMEM260 TMEM260 SI SI FABP6 FABP6 RPL4 RPL4 MAGI3 MAGI3 LOC111772308 LOC111772308 ACTBL2 ACTBL2 MUC13 MUC13 SLC10A2 SLC10A2 LOC111771820 LOC111771820 LOC111767504 LOC111767504 DHX35 DHX35 HHLA2 HHLA2 TLR3 TLR3 TRPC4 TRPC4 LOC111771935 LOC111771935 ENSECAP00000036381 ENSECAP00000036381 ANPEP ANPEP DENND1C DENND1C NAALADL1 NAALADL1 TTC38 TTC38 AOC1 AOC1 MLLT6 MLLT6 FAM13A FAM13A ACTL8 ACTL8 VSIG10 VSIG10 CDC42EP4 CDC42EP4 DCAF10 DCAF10 CD4 CD4 OCLN OCLN TLR4 TLR4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMTNL1Smoothelin like 1. (458 aa)
C1H14orf119Chromosome 1 C14orf119 homolog. (143 aa)
TM4SF20Transmembrane 4 L six family member 20. (227 aa)
POF1BPOF1B actin binding protein. (589 aa)
PEX26Peroxisomal biogenesis factor 26. (320 aa)
COG4Component of oligomeric golgi complex 4. (789 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (377 aa)
GALGalanin and GMAP prepropeptide. (123 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
ACTG1Actin gamma 1. (462 aa)
CLCA1Calcium-activated chloride channel regulator 1; May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC (By similarity). (984 aa)
TMIGD1Transmembrane and immunoglobulin domain containing 1. (262 aa)
TMEM260Transmembrane protein 260. (705 aa)
SISucrase-isomaltase. (1824 aa)
FABP6Fatty acid binding protein 6. (128 aa)
RPL4Ribosomal protein L4. (481 aa)
MAGI3Membrane associated guanylate kinase, WW and PDZ domain containing 3. (1481 aa)
LOC111772308Protein POF1B. (589 aa)
ACTBL2Actin beta like 2. (376 aa)
MUC13Uncharacterized protein. (466 aa)
SLC10A2Solute carrier family 10 member 2. (348 aa)
LOC111771820Protein POF1B. (589 aa)
LOC111767504Aminopeptidase. (967 aa)
DHX35DEAH-box helicase 35. (716 aa)
HHLA2HERV-H LTR-associating 2. (405 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (979 aa)
TRPC4Transient receptor potential cation channel subfamily C member 4; Belongs to the transient receptor (TC 1.A.4) family. (982 aa)
LOC111771935Toll-like receptor 4. (843 aa)
ENSECAP00000036381TIR domain-containing protein; Belongs to the Toll-like receptor family. (772 aa)
ANPEPAminopeptidase. (888 aa)
DENND1CDENN domain containing 1C. (849 aa)
NAALADL1N-acetylated alpha-linked acidic dipeptidase like 1. (745 aa)
TTC38Tetratricopeptide repeat domain 38. (469 aa)
AOC1Amine oxidase. (793 aa)
MLLT6MLLT6, PHD finger containing. (1110 aa)
FAM13AFamily with sequence similarity 13 member A. (1038 aa)
ACTL8Actin like 8; Belongs to the actin family. (366 aa)
VSIG10V-set and immunoglobulin domain containing 10. (534 aa)
CDC42EP4CDC42 effector protein 4. (335 aa)
DCAF10DDB1 and CUL4 associated factor 10. (555 aa)
CD4CD4 molecule. (460 aa)
OCLNOccludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. (520 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (843 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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