STRINGSTRING
CCRL2 CCRL2 TNF TNF NRIP1 NRIP1 DDI1 DDI1 MPO MPO APOE APOE IL4 IL4 CD300E CD300E IL10 IL10 CD4 CD4 ABCA1 ABCA1 TLR4 TLR4 NFKBIZ NFKBIZ OLR1 OLR1 CXCL11 CXCL11 TOR2A TOR2A IL6 IL6 IL12RB2 IL12RB2 ABCA2 ABCA2 CLEC17A CLEC17A EPX EPX PIK3CG PIK3CG IL1B IL1B TFE3 TFE3 KLF15 KLF15 CCL2 CCL2 KIRREL3 KIRREL3 ABCG1 ABCG1 LOC111768185 LOC111768185 CCL24 CCL24 ENSECAP00000028450 ENSECAP00000028450 KIRREL1 KIRREL1 IFNG IFNG TNIP3 TNIP3 CD36 CD36 VSTM1 VSTM1 LOC100072933 LOC100072933 LOC111771935 LOC111771935 CCL17 CCL17 GCA GCA RSC1A1 RSC1A1 PTPRC PTPRC AZU1 AZU1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCRL2C-C motif chemokine receptor like 2; Belongs to the G-protein coupled receptor 1 family. (353 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa)
NRIP1Nuclear receptor interacting protein 1. (1155 aa)
DDI1DNA damage inducible 1 homolog 1. (400 aa)
MPOMyeloperoxidase. (724 aa)
APOEApolipoprotein E. (310 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (139 aa)
CD300ECD300e molecule. (225 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (249 aa)
CD4CD4 molecule. (460 aa)
ABCA1ATP binding cassette subfamily A member 1. (2304 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (843 aa)
NFKBIZNFKB inhibitor zeta. (711 aa)
OLR1Oxidized low density lipoprotein receptor 1. (278 aa)
CXCL11C-X-C motif chemokine. (100 aa)
TOR2ATorsin. (321 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (231 aa)
IL12RB2Interleukin 12 receptor subunit beta 2. (906 aa)
ABCA2ATP binding cassette subfamily A member 2. (2545 aa)
CLEC17AC-type lectin domain containing 17A. (313 aa)
EPXEosinophil peroxidase. (715 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. (268 aa)
TFE3Transcription factor binding to IGHM enhancer 3. (575 aa)
KLF15Kruppel like factor 15. (412 aa)
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (99 aa)
KIRREL3Kirre like nephrin family adhesion molecule 3. (778 aa)
ABCG1ATP binding cassette subfamily G member 1. (735 aa)
LOC111768185Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
CCL24C-C motif chemokine ligand 24. (109 aa)
ENSECAP00000028450SCY domain-containing protein. (96 aa)
KIRREL1Kirre like nephrin family adhesion molecule 1. (819 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
TNIP3TNFAIP3 interacting protein 3. (393 aa)
CD36CD36 molecule; Belongs to the CD36 family. (472 aa)
VSTM1V-set and transmembrane domain containing 1. (248 aa)
LOC100072933Uncharacterized protein. (305 aa)
LOC111771935Toll-like receptor 4. (843 aa)
CCL17C-C motif chemokine. (198 aa)
GCAGrancalcin. (242 aa)
RSC1A1Regulator of solute carriers 1. (620 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1399 aa)
AZU1Azurocidin 1. (251 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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