STRINGSTRING
KITLG KITLG EREG EREG KL KL NTF4 NTF4 ANGPT4 ANGPT4 INSR INSR NGF NGF VEGFB VEGFB TGFA TGFA EGF EGF KIT KIT FGF10 FGF10 FGF2 FGF2 INSRR INSRR FGF7 FGF7 FGF5 FGF5 ANGPT2 ANGPT2 ANGPT1 ANGPT1 TEK TEK NGFR NGFR FGF9 FGF9 PDGFC PDGFC KDR KDR FGF1 FGF1 FGF23 FGF23 IGF1R IGF1R FGF6 FGF6 AREG AREG KLB KLB ERBB4 ERBB4 NTF3 NTF3 INS INS ERBB3 ERBB3 FGF17 FGF17 PDGFRB PDGFRB FLT4 FLT4 FLT1 FLT1 NRG4 NRG4 FGF19 FGF19 PDGFB PDGFB PDGFD PDGFD FGF18 FGF18 ERBB2 ERBB2 FLT3LG FLT3LG FGF16 FGF16 FGF22 FGF22 NRG2 NRG2 NTRK2 NTRK2 FGF12 FGF12 VEGFD VEGFD IGF1 IGF1 NTRK1 NTRK1 FGFRL1 FGFRL1 NTRK3 NTRK3 BDNF BDNF VEGFC VEGFC FGF20 FGF20 LOC100068923 LOC100068923 FGF4 FGF4 FGF3 FGF3 KIDINS220 KIDINS220 PDGFA PDGFA FGF13 FGF13 PDGFRA PDGFRA FGFR1 FGFR1 BTC BTC PGF PGF FGFR2 FGFR2 FGF8 FGF8 FLT3 FLT3 FGFR4 FGFR4 PTPRS PTPRS EPGN EPGN FGFR3 FGFR3 NRG3 NRG3 NRG1 NRG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KITLGProcessed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family. (303 aa)
EREGEpiregulin. (170 aa)
KLKlotho. (1011 aa)
NTF4Neurotrophin 4; Belongs to the NGF-beta family. (210 aa)
ANGPT4Angiopoietin 4. (497 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (294 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (207 aa)
TGFATransforming growth factor alpha. (221 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1209 aa)
KITKIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1084 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
INSRRTyrosine-protein kinase receptor. (1334 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
FGF5Fibroblast growth factor 5. (280 aa)
ANGPT2Angiopoietin 2. (496 aa)
ANGPT1Angiopoietin 1. (498 aa)
TEKTEK receptor tyrosine kinase. (1153 aa)
NGFRNerve growth factor receptor. (435 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (368 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1358 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (244 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
AREGAmphiregulin. (247 aa)
KLBKlotho beta. (1045 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (270 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1339 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (240 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1366 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1336 aa)
NRG4Neuregulin 4. (116 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (249 aa)
PDGFDPlatelet derived growth factor D. (566 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
FLT3LGFms related tyrosine kinase 3 ligand. (241 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGF22Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (172 aa)
NRG2Neuregulin 2. (923 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (235 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
NTRK1Tyrosine-protein kinase receptor. (880 aa)
FGFRL1Fibroblast growth factor receptor like 1. (522 aa)
NTRK3Tyrosine-protein kinase receptor. (863 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (299 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
LOC100068923Uncharacterized protein. (212 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (231 aa)
KIDINS220Kinase D interacting substrate 220. (1785 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (569 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (278 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
FGFR1Fibroblast growth factor receptor. (877 aa)
BTCBetacellulin. (188 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (210 aa)
FGFR2Fibroblast growth factor receptor. (887 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
FLT3Fms related tyrosine kinase 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1020 aa)
FGFR4Fibroblast growth factor receptor. (855 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1948 aa)
EPGNEpithelial mitogen. (154 aa)
FGFR3Fibroblast growth factor receptor. (804 aa)
NRG3Neuregulin 3. (727 aa)
NRG1Neuregulin 1. (712 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.