(15 nodes) Integrin domain superfamily, and Alpha-catenin/vinculin-like superfamily network (Equus caballus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	FN1	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). (2477 aa)
	FERMT3	Fermitin family member 3. (699 aa)
	VCL	Vinculin. (1284 aa)
	ITGA8	Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1062 aa)
	VTN	Vitronectin. (478 aa)
	SORBS3	Sorbin and SH3 domain containing 3. (719 aa)
	PELO	Integrin subunit alpha 1; Belongs to the integrin alpha chain family. (1208 aa)
	TLN1	Talin 1. (2558 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (784 aa)
	ITGB8	Integrin beta; Belongs to the integrin beta chain family. (767 aa)
	ITGA2B	Integrin subunit alpha 2b; Belongs to the integrin alpha chain family. (1108 aa)
	TLN2	Talin 2. (2572 aa)
	ITGB5	Integrin beta; Belongs to the integrin beta chain family. (837 aa)
	PXN	Paxillin. (1236 aa)
	SORBS1	Sorbin and SH3 domain containing 1. (1294 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FERMT3	ITGA2B	ENSECAP00000006635	ENSECAP00000018357	Fermitin family member 3.	Integrin subunit alpha 2b; Belongs to the integrin alpha chain family.	0.934
FERMT3	ITGB3	ENSECAP00000006635	ENSECAP00000016485	Fermitin family member 3.	Integrin beta; Belongs to the integrin beta chain family.	0.974
FERMT3	ITGB5	ENSECAP00000006635	ENSECAP00000035882	Fermitin family member 3.	Integrin beta; Belongs to the integrin beta chain family.	0.756
FERMT3	ITGB8	ENSECAP00000006635	ENSECAP00000016855	Fermitin family member 3.	Integrin beta; Belongs to the integrin beta chain family.	0.756
FERMT3	PXN	ENSECAP00000006635	ENSECAP00000043492	Fermitin family member 3.	Paxillin.	0.439
FERMT3	TLN1	ENSECAP00000006635	ENSECAP00000015561	Fermitin family member 3.	Talin 1.	0.625
FERMT3	TLN2	ENSECAP00000006635	ENSECAP00000019323	Fermitin family member 3.	Talin 2.	0.627
FN1	ITGA2B	ENSECAP00000005223	ENSECAP00000018357	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	Integrin subunit alpha 2b; Belongs to the integrin alpha chain family.	0.927
FN1	ITGA8	ENSECAP00000005223	ENSECAP00000011756	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	Integrin subunit alpha 8; Belongs to the integrin alpha chain family.	0.927
FN1	ITGB3	ENSECAP00000005223	ENSECAP00000016485	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	Integrin beta; Belongs to the integrin beta chain family.	0.963
FN1	ITGB5	ENSECAP00000005223	ENSECAP00000035882	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	Integrin beta; Belongs to the integrin beta chain family.	0.942
FN1	ITGB8	ENSECAP00000005223	ENSECAP00000016855	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	Integrin beta; Belongs to the integrin beta chain family.	0.940
FN1	PELO	ENSECAP00000005223	ENSECAP00000015387	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	Integrin subunit alpha 1; Belongs to the integrin alpha chain family.	0.659
FN1	PXN	ENSECAP00000005223	ENSECAP00000043492	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	Paxillin.	0.441
FN1	TLN2	ENSECAP00000005223	ENSECAP00000019323	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	Talin 2.	0.419
FN1	VCL	ENSECAP00000005223	ENSECAP00000011648	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	Vinculin.	0.503
FN1	VTN	ENSECAP00000005223	ENSECAP00000013752	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	Vitronectin.	0.678
ITGA2B	FERMT3	ENSECAP00000018357	ENSECAP00000006635	Integrin subunit alpha 2b; Belongs to the integrin alpha chain family.	Fermitin family member 3.	0.934
ITGA2B	FN1	ENSECAP00000018357	ENSECAP00000005223	Integrin subunit alpha 2b; Belongs to the integrin alpha chain family.	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).	0.927
ITGA2B	ITGB3	ENSECAP00000018357	ENSECAP00000016485	Integrin subunit alpha 2b; Belongs to the integrin alpha chain family.	Integrin beta; Belongs to the integrin beta chain family.	0.999