STRINGSTRING
IL4 IL4 IL13 IL13 LOC111769802 LOC111769802 IL21 IL21 IL2 IL2 IL2RB IL2RB IL21R IL21R IL13RA1 IL13RA1 IL7 IL7 IL9R IL9R IL9 IL9 IL15 IL15 IL2RA IL2RA IL13RA2 IL13RA2 IL15RA IL15RA IL2RG IL2RG IL4R IL4R
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (139 aa)
IL13Interleukin-13. (133 aa)
LOC111769802Interleukin-7 receptor subunit alpha; Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP) (By similarity); Belongs to the type I cytokine receptor family. Type 4 subfamily. (458 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (158 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (149 aa)
IL2RBInterleukin 2 receptor subunit beta. (558 aa)
IL21RInterleukin 21 receptor. (557 aa)
IL13RA1Interleukin 13 receptor subunit alpha 1. (424 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (176 aa)
IL9RInterleukin 9 receptor. (499 aa)
IL9Interleukin 9. (147 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (432 aa)
IL2RAInterleukin 2 receptor subunit alpha. (275 aa)
IL13RA2Interleukin 13 receptor subunit alpha 2. (418 aa)
IL15RAInterleukin 15 receptor subunit alpha. (260 aa)
IL2RGFibronectin type-III domain-containing protein. (457 aa)
IL4RInterleukin-4 receptor subunit alpha; Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 (By similarity). (831 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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