STRINGSTRING
PTPN2 PTPN2 SOCS3 SOCS3 STAT6 STAT6 IFNGR1 IFNGR1 JAK2 JAK2 IFNAR1 IFNAR1 JAK1 JAK1 TYK2 TYK2 STAT2 STAT2 STAT4 STAT4 IRF9 IRF9 SOCS1 SOCS1 IFNG IFNG STAT1 STAT1 STAT5B STAT5B STAT3 STAT3 STAT5A STAT5A JAK3 JAK3 IFNAR2 IFNAR2 LOC100147174 LOC100147174 IFNGR2 IFNGR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTPN2Tyrosine-protein phosphatase non-receptor type. (388 aa)
SOCS3Suppressor of cytokine signaling 3. (229 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
IFNGR1Interferon gamma receptor 1. (472 aa)
JAK2Tyrosine-protein kinase. (1131 aa)
IFNAR1Interferon alpha and beta receptor subunit 1. (561 aa)
JAK1Tyrosine-protein kinase. (1141 aa)
TYK2Tyrosine-protein kinase. (1262 aa)
STAT2Signal transducer and activator of transcription. (847 aa)
STAT4Signal transducer and activator of transcription. (748 aa)
IRF9Interferon regulatory factor 9. (394 aa)
SOCS1Suppressor of cytokine signaling 1. (222 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
STAT1Signal transducer and activator of transcription. (749 aa)
STAT5BSignal transducer and activator of transcription. (825 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
STAT5ASignal transducer and activator of transcription. (800 aa)
JAK3Tyrosine-protein kinase. (1139 aa)
IFNAR2Uncharacterized protein. (530 aa)
LOC100147174Uncharacterized protein. (186 aa)
IFNGR2Interferon gamma receptor 2. (461 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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