(11 nodes) CXCR3 chemokine receptor binding, and Eosinophil migration network (Equus caballus)

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Your Input:
	CCR5	Chemokine receptor 5/2 large transcript; Belongs to the G-protein coupled receptor 1 family. (354 aa)
	CCR2	C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (380 aa)
	CXCL11	C-X-C motif chemokine. (100 aa)
	LOC100630489	C-X-C motif chemokine. (110 aa)
	CXCL10	C-X-C motif chemokine. (104 aa)
	CXCR3	C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (369 aa)
	CCL8	SCY domain-containing protein. (99 aa)
	CCL2	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (99 aa)
	CCL5	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (91 aa)
	CCL4	SCY domain-containing protein. (97 aa)
	CCL3	SCY domain-containing protein. (226 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCL2	CCL3	ENSECAP00000021376	ENSECAP00000047808	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	SCY domain-containing protein.	0.821
CCL2	CCL4	ENSECAP00000021376	ENSECAP00000046856	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	SCY domain-containing protein.	0.992
CCL2	CCL5	ENSECAP00000021376	ENSECAP00000022430	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	0.984
CCL2	CCL8	ENSECAP00000021376	ENSECAP00000021367	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	SCY domain-containing protein.	0.990
CCL2	CCR2	ENSECAP00000021376	ENSECAP00000000857	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.999
CCL2	CCR5	ENSECAP00000021376	ENSECAP00000000806	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	Chemokine receptor 5/2 large transcript; Belongs to the G-protein coupled receptor 1 family.	0.968
CCL2	CXCL10	ENSECAP00000021376	ENSECAP00000011110	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	C-X-C motif chemokine.	0.963
CCL2	CXCL11	ENSECAP00000021376	ENSECAP00000010001	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	C-X-C motif chemokine.	0.816
CCL2	CXCR3	ENSECAP00000021376	ENSECAP00000020988	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	0.968
CCL2	LOC100630489	ENSECAP00000021376	ENSECAP00000010335	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	C-X-C motif chemokine.	0.851
CCL3	CCL2	ENSECAP00000047808	ENSECAP00000021376	SCY domain-containing protein.	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	0.821
CCL3	CCL4	ENSECAP00000047808	ENSECAP00000046856	SCY domain-containing protein.	SCY domain-containing protein.	0.944
CCL3	CCL5	ENSECAP00000047808	ENSECAP00000022430	SCY domain-containing protein.	C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family.	0.710
CCL3	CCL8	ENSECAP00000047808	ENSECAP00000021367	SCY domain-containing protein.	SCY domain-containing protein.	0.409
CCL3	CCR2	ENSECAP00000047808	ENSECAP00000000857	SCY domain-containing protein.	C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.848
CCL3	CCR5	ENSECAP00000047808	ENSECAP00000000806	SCY domain-containing protein.	Chemokine receptor 5/2 large transcript; Belongs to the G-protein coupled receptor 1 family.	0.994
CCL3	CXCL10	ENSECAP00000047808	ENSECAP00000011110	SCY domain-containing protein.	C-X-C motif chemokine.	0.951
CCL3	CXCL11	ENSECAP00000047808	ENSECAP00000010001	SCY domain-containing protein.	C-X-C motif chemokine.	0.802
CCL3	CXCR3	ENSECAP00000047808	ENSECAP00000020988	SCY domain-containing protein.	C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family.	0.685
CCL3	LOC100630489	ENSECAP00000047808	ENSECAP00000010335	SCY domain-containing protein.	C-X-C motif chemokine.	0.685