(5 nodes) Mixed, incl. CD40 receptor binding, and Cytotoxic T-lymphocyte protein 4/CD28 network (Equus caballus)

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Your Input:
	CTLA4	Cytotoxic T-lymphocyte associated protein 4. (223 aa)
	CD40	Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). (280 aa)
	CD80	CD80 molecule. (305 aa)
	CD86	CD86 molecule. (335 aa)
	CD40LG	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD40	CD40LG	ENSECAP00000014907	ENSECAP00000050128	Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.999
CD40	CD80	ENSECAP00000014907	ENSECAP00000033208	Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).	CD80 molecule.	0.976
CD40	CD86	ENSECAP00000014907	ENSECAP00000040346	Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).	CD86 molecule.	0.976
CD40	CTLA4	ENSECAP00000014907	ENSECAP00000002814	Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).	Cytotoxic T-lymphocyte associated protein 4.	0.894
CD40LG	CD40	ENSECAP00000050128	ENSECAP00000014907	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).	0.999
CD40LG	CD80	ENSECAP00000050128	ENSECAP00000033208	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	CD80 molecule.	0.964
CD40LG	CD86	ENSECAP00000050128	ENSECAP00000040346	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	CD86 molecule.	0.960
CD40LG	CTLA4	ENSECAP00000050128	ENSECAP00000002814	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	Cytotoxic T-lymphocyte associated protein 4.	0.886
CD80	CD40	ENSECAP00000033208	ENSECAP00000014907	CD80 molecule.	Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).	0.976
CD80	CD40LG	ENSECAP00000033208	ENSECAP00000050128	CD80 molecule.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.964
CD80	CD86	ENSECAP00000033208	ENSECAP00000040346	CD80 molecule.	CD86 molecule.	0.999
CD80	CTLA4	ENSECAP00000033208	ENSECAP00000002814	CD80 molecule.	Cytotoxic T-lymphocyte associated protein 4.	0.999
CD86	CD40	ENSECAP00000040346	ENSECAP00000014907	CD86 molecule.	Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).	0.976
CD86	CD40LG	ENSECAP00000040346	ENSECAP00000050128	CD86 molecule.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.960
CD86	CD80	ENSECAP00000040346	ENSECAP00000033208	CD86 molecule.	CD80 molecule.	0.999
CD86	CTLA4	ENSECAP00000040346	ENSECAP00000002814	CD86 molecule.	Cytotoxic T-lymphocyte associated protein 4.	0.999
CTLA4	CD40	ENSECAP00000002814	ENSECAP00000014907	Cytotoxic T-lymphocyte associated protein 4.	Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).	0.894
CTLA4	CD40LG	ENSECAP00000002814	ENSECAP00000050128	Cytotoxic T-lymphocyte associated protein 4.	CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.	0.886
CTLA4	CD80	ENSECAP00000002814	ENSECAP00000033208	Cytotoxic T-lymphocyte associated protein 4.	CD80 molecule.	0.999
CTLA4	CD86	ENSECAP00000002814	ENSECAP00000040346	Cytotoxic T-lymphocyte associated protein 4.	CD86 molecule.	0.999