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TLR6 TLR6 TNF TNF MYD88 MYD88 NAIP NAIP REL REL TICAM1 TICAM1 MEFV MEFV TRAF5 TRAF5 UNC93B1 UNC93B1 NLRP1 NLRP1 TLR8 TLR8 TNFAIP3 TNFAIP3 PYCARD PYCARD TLR4 TLR4 TNIP1 TNIP1 TIRAP TIRAP IRAK2 IRAK2 CASP4 CASP4 TRAF2 TRAF2 RELA RELA TLR9 TLR9 MAP3K14 MAP3K14 GSDMD GSDMD IRAK4 IRAK4 NLRP3 NLRP3 NFKB1 NFKB1 NOD2 NOD2 LY96 LY96 NLRP12 NLRP12 TLR2 TLR2 TAB2 TAB2 NLRP10 NLRP10 TOLLIP TOLLIP NLRC4 NLRC4 NFKBIE NFKBIE IKBKG IKBKG TLR10 TLR10 RELB RELB TBK1 TBK1 TRAF6 TRAF6 NFKBIA NFKBIA CASP1 CASP1 IRAK3 IRAK3 TRAF4 TRAF4 TANK TANK IKBKE IKBKE TLR7 TLR7 TLR1 TLR1 LOC100069322 LOC100069322 NLRP6 NLRP6 PSTPIP1 PSTPIP1 TAB1 TAB1 IKBKB IKBKB TLR3 TLR3 RIPK2 RIPK2 LOC111771935 LOC111771935 SIGIRR SIGIRR NFKB2 NFKB2 ENSECAP00000036381 ENSECAP00000036381 CHUK CHUK IRF5 IRF5 AIM2 AIM2 ENSECAP00000039214 ENSECAP00000039214 TLR5 TLR5 NOD1 NOD1 MAP3K8 MAP3K8 TRAF3 TRAF3 IRAK1 IRAK1 TAB3 TAB3 TNIP2 TNIP2 TRAF1 TRAF1 NFKBIB NFKBIB CBLC CBLC MAP3K7 MAP3K7 TNFRSF1B TNFRSF1B IL1B IL1B TNFRSF1A TNFRSF1A BIRC2 BIRC2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TLR6Toll-like receptor. (859 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
NAIPNLR family apoptosis inhibitory protein. (1402 aa)
RELREL proto-oncogene, NF-kB subunit. (596 aa)
TICAM1Toll like receptor adaptor molecule 1. (698 aa)
MEFVMEFV innate immuity regulator, pyrin. (117 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
UNC93B1Unc-93 homolog B1, TLR signaling regulator. (571 aa)
NLRP1NLR family pyrin domain containing 1. (1448 aa)
TLR8Toll-like receptor 8; Belongs to the Toll-like receptor family. (1038 aa)
TNFAIP3TNF alpha induced protein 3. (794 aa)
PYCARDPYD and CARD domain containing. (195 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (843 aa)
TNIP1TNFAIP3 interacting protein 1. (723 aa)
TIRAPTIR domain containing adaptor protein. (234 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (621 aa)
CASP4Uncharacterized protein; Belongs to the peptidase C14A family. (370 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
TLR9Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1031 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (955 aa)
GSDMDGasdermin D. (485 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
NLRP3NLR family pyrin domain containing 3. (1031 aa)
NFKB1Nuclear factor kappa B subunit 1. (1049 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1013 aa)
LY96Lymphocyte antigen 96. (173 aa)
NLRP12NLR family pyrin domain containing 12. (1061 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
NLRP10NLR family pyrin domain containing 10. (632 aa)
TOLLIPToll interacting protein. (274 aa)
NLRC4NLR family CARD domain containing 4. (1053 aa)
NFKBIENFKB inhibitor epsilon. (362 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
TLR10Toll like receptor 10; Belongs to the Toll-like receptor family. (811 aa)
RELBRELB proto-oncogene, NF-kB subunit. (709 aa)
TBK1TANK binding kinase 1. (729 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (564 aa)
NFKBIANFKB inhibitor alpha. (543 aa)
CASP1Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...] (405 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (614 aa)
TRAF4TNF receptor-associated factor. (470 aa)
TANKTRAF family member associated NFKB activator. (426 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (822 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1054 aa)
TLR1Toll-like receptor. (756 aa)
LOC100069322Uncharacterized protein; Belongs to the peptidase C14A family. (350 aa)
NLRP6NLR family pyrin domain containing 6. (892 aa)
PSTPIP1Proline-serine-threonine phosphatase interacting protein 1. (491 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (654 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (770 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (979 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (569 aa)
LOC111771935Toll-like receptor 4. (843 aa)
SIGIRRSingle Ig and TIR domain containing. (509 aa)
NFKB2Nuclear factor kappa B subunit 2. (1024 aa)
ENSECAP00000036381TIR domain-containing protein; Belongs to the Toll-like receptor family. (772 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
IRF5Interferon regulatory factor 5. (683 aa)
AIM2Absent in melanoma 2. (352 aa)
ENSECAP00000039214Pyrin domain-containing protein. (96 aa)
TLR5Toll like receptor 5; Belongs to the Toll-like receptor family. (867 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (993 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (467 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (805 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (717 aa)
TNIP2TNFAIP3 interacting protein 2. (592 aa)
TRAF1TNF receptor-associated factor. (415 aa)
NFKBIBNFKB inhibitor beta. (371 aa)
CBLCANK_REP_REGION domain-containing protein. (912 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (615 aa)
TNFRSF1BTNF receptor superfamily member 1B. (481 aa)
IL1BInterleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. (268 aa)
TNFRSF1ATNF receptor superfamily member 1A. (475 aa)
BIRC2Baculoviral IAP repeat containing 3. (604 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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