STRINGSTRING
TLR6 TLR6 TNF TNF MYD88 MYD88 TICAM1 TICAM1 TRAF5 TRAF5 UNC93B1 UNC93B1 TLR8 TLR8 TLR4 TLR4 TIRAP TIRAP IRAK2 IRAK2 TRAF2 TRAF2 TLR9 TLR9 IRAK4 IRAK4 LY96 LY96 TLR2 TLR2 TAB2 TAB2 TOLLIP TOLLIP IKBKG IKBKG TBK1 TBK1 TRAF6 TRAF6 TRAF4 TRAF4 TANK TANK IKBKE IKBKE TLR7 TLR7 TLR1 TLR1 TAB1 TAB1 TLR3 TLR3 LOC111771935 LOC111771935 ENSECAP00000036381 ENSECAP00000036381 IRF5 IRF5 TLR5 TLR5 TRAF3 TRAF3 IRAK1 IRAK1 TAB3 TAB3 TRAF1 TRAF1 MAP3K7 MAP3K7 TNFRSF1B TNFRSF1B TNFRSF1A TNFRSF1A BIRC2 BIRC2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TLR6Toll-like receptor. (859 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
TICAM1Toll like receptor adaptor molecule 1. (698 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
UNC93B1Unc-93 homolog B1, TLR signaling regulator. (571 aa)
TLR8Toll-like receptor 8; Belongs to the Toll-like receptor family. (1038 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (843 aa)
TIRAPTIR domain containing adaptor protein. (234 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (621 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
TLR9Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1031 aa)
IRAK4Interleukin 1 receptor associated kinase 4. (460 aa)
LY96Lymphocyte antigen 96. (173 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (693 aa)
TOLLIPToll interacting protein. (274 aa)
IKBKGInhibitor of nuclear factor kappa B kinase regulatory subunit gamma. (419 aa)
TBK1TANK binding kinase 1. (729 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (564 aa)
TRAF4TNF receptor-associated factor. (470 aa)
TANKTRAF family member associated NFKB activator. (426 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (822 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1054 aa)
TLR1Toll-like receptor. (756 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (654 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (979 aa)
LOC111771935Toll-like receptor 4. (843 aa)
ENSECAP00000036381TIR domain-containing protein; Belongs to the Toll-like receptor family. (772 aa)
IRF5Interferon regulatory factor 5. (683 aa)
TLR5Toll like receptor 5; Belongs to the Toll-like receptor family. (867 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (805 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (717 aa)
TRAF1TNF receptor-associated factor. (415 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (615 aa)
TNFRSF1BTNF receptor superfamily member 1B. (481 aa)
TNFRSF1ATNF receptor superfamily member 1A. (475 aa)
BIRC2Baculoviral IAP repeat containing 3. (604 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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