(12 nodes) Activation of caspases through apoptosome-mediated cleavage, and BIR repeat network (Equus caballus)

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Your Input:
	HTRA2	HtrA serine peptidase 2. (458 aa)
	GAS2	Growth arrest specific 2. (331 aa)
	BIRC5	Baculoviral IAP repeat containing 5. (226 aa)
	CYCS	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
	BIRC7	Baculoviral IAP repeat containing 7. (282 aa)
	DIABLO	Diablo IAP-binding mitochondrial protein. (237 aa)
	BIRC6	Baculoviral IAP repeat containing 6. (4891 aa)
	CASP3	Caspase-3-like protein; Belongs to the peptidase C14A family. (277 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1256 aa)
	XIAP	X-linked inhibitor of apoptosis. (494 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (632 aa)
	CASP7	Caspase 7; Belongs to the peptidase C14A family. (347 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	BIRC5	ENSECAP00000022364	ENSECAP00000006490	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat containing 5.	0.653
APAF1	BIRC6	ENSECAP00000022364	ENSECAP00000017955	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat containing 6.	0.792
APAF1	BIRC7	ENSECAP00000022364	ENSECAP00000017749	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Baculoviral IAP repeat containing 7.	0.681
APAF1	CASP3	ENSECAP00000022364	ENSECAP00000019797	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase-3-like protein; Belongs to the peptidase C14A family.	0.997
APAF1	CASP7	ENSECAP00000022364	ENSECAP00000045690	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 7; Belongs to the peptidase C14A family.	0.909
APAF1	CASP9	ENSECAP00000022364	ENSECAP00000039254	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 9; Belongs to the peptidase C14A family.	0.999
APAF1	CYCS	ENSECAP00000022364	ENSECAP00000012031	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.	0.999
APAF1	DIABLO	ENSECAP00000022364	ENSECAP00000017797	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Diablo IAP-binding mitochondrial protein.	0.850
APAF1	HTRA2	ENSECAP00000022364	ENSECAP00000000520	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	HtrA serine peptidase 2.	0.695
APAF1	XIAP	ENSECAP00000022364	ENSECAP00000024181	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	X-linked inhibitor of apoptosis.	0.918
BIRC5	APAF1	ENSECAP00000006490	ENSECAP00000022364	Baculoviral IAP repeat containing 5.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.653
BIRC5	BIRC6	ENSECAP00000006490	ENSECAP00000017955	Baculoviral IAP repeat containing 5.	Baculoviral IAP repeat containing 6.	0.937
BIRC5	BIRC7	ENSECAP00000006490	ENSECAP00000017749	Baculoviral IAP repeat containing 5.	Baculoviral IAP repeat containing 7.	0.429
BIRC5	CASP3	ENSECAP00000006490	ENSECAP00000019797	Baculoviral IAP repeat containing 5.	Caspase-3-like protein; Belongs to the peptidase C14A family.	0.957
BIRC5	CASP7	ENSECAP00000006490	ENSECAP00000045690	Baculoviral IAP repeat containing 5.	Caspase 7; Belongs to the peptidase C14A family.	0.432
BIRC5	CASP9	ENSECAP00000006490	ENSECAP00000039254	Baculoviral IAP repeat containing 5.	Caspase 9; Belongs to the peptidase C14A family.	0.961
BIRC5	DIABLO	ENSECAP00000006490	ENSECAP00000017797	Baculoviral IAP repeat containing 5.	Diablo IAP-binding mitochondrial protein.	0.974
BIRC5	HTRA2	ENSECAP00000006490	ENSECAP00000000520	Baculoviral IAP repeat containing 5.	HtrA serine peptidase 2.	0.926
BIRC5	XIAP	ENSECAP00000006490	ENSECAP00000024181	Baculoviral IAP repeat containing 5.	X-linked inhibitor of apoptosis.	0.955
BIRC6	APAF1	ENSECAP00000017955	ENSECAP00000022364	Baculoviral IAP repeat containing 6.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.792