(5 nodes) Nuclear receptor coactivator, and Nuclear estrogen receptor activity network (Equus caballus)

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Your Input:
	ESR1	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (608 aa)
	ESR2	Estrogen receptor 2. (550 aa)
	NCOA2	Nuclear receptor coactivator. (1481 aa)
	NCOA1	Nuclear receptor coactivator. (1442 aa)
	NCOA3	Nuclear receptor coactivator. (1427 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ESR1	ESR2	ENSECAP00000020141	ENSECAP00000022532	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	Estrogen receptor 2.	0.997
ESR1	NCOA1	ENSECAP00000020141	ENSECAP00000038479	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	Nuclear receptor coactivator.	0.998
ESR1	NCOA2	ENSECAP00000020141	ENSECAP00000023894	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	Nuclear receptor coactivator.	0.995
ESR1	NCOA3	ENSECAP00000020141	ENSECAP00000044340	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	Nuclear receptor coactivator.	0.998
ESR2	ESR1	ENSECAP00000022532	ENSECAP00000020141	Estrogen receptor 2.	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	0.997
ESR2	NCOA1	ENSECAP00000022532	ENSECAP00000038479	Estrogen receptor 2.	Nuclear receptor coactivator.	0.986
ESR2	NCOA2	ENSECAP00000022532	ENSECAP00000023894	Estrogen receptor 2.	Nuclear receptor coactivator.	0.960
ESR2	NCOA3	ENSECAP00000022532	ENSECAP00000044340	Estrogen receptor 2.	Nuclear receptor coactivator.	0.982
NCOA1	ESR1	ENSECAP00000038479	ENSECAP00000020141	Nuclear receptor coactivator.	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	0.998
NCOA1	ESR2	ENSECAP00000038479	ENSECAP00000022532	Nuclear receptor coactivator.	Estrogen receptor 2.	0.986
NCOA1	NCOA2	ENSECAP00000038479	ENSECAP00000023894	Nuclear receptor coactivator.	Nuclear receptor coactivator.	0.996
NCOA1	NCOA3	ENSECAP00000038479	ENSECAP00000044340	Nuclear receptor coactivator.	Nuclear receptor coactivator.	0.979
NCOA2	ESR1	ENSECAP00000023894	ENSECAP00000020141	Nuclear receptor coactivator.	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	0.995
NCOA2	ESR2	ENSECAP00000023894	ENSECAP00000022532	Nuclear receptor coactivator.	Estrogen receptor 2.	0.960
NCOA2	NCOA1	ENSECAP00000023894	ENSECAP00000038479	Nuclear receptor coactivator.	Nuclear receptor coactivator.	0.996
NCOA2	NCOA3	ENSECAP00000023894	ENSECAP00000044340	Nuclear receptor coactivator.	Nuclear receptor coactivator.	0.970
NCOA3	ESR1	ENSECAP00000044340	ENSECAP00000020141	Nuclear receptor coactivator.	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	0.998
NCOA3	ESR2	ENSECAP00000044340	ENSECAP00000022532	Nuclear receptor coactivator.	Estrogen receptor 2.	0.982
NCOA3	NCOA1	ENSECAP00000044340	ENSECAP00000038479	Nuclear receptor coactivator.	Nuclear receptor coactivator.	0.979
NCOA3	NCOA2	ENSECAP00000044340	ENSECAP00000023894	Nuclear receptor coactivator.	Nuclear receptor coactivator.	0.970