(6 nodes) Protein neddylation network (Equus caballus)

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Your Input:
	UBE2F	Ubiquitin conjugating enzyme E2 F (putative); Belongs to the ubiquitin-conjugating enzyme family. (185 aa)
	UBE2M	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
	DCUN1D3	DCN1-like protein. (304 aa)
	NAE1	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (488 aa)
	NEDD8	NEDD8 ubiquitin like modifier. (81 aa)
	UBA3	Ubiquitin like modifier activating enzyme 3. (599 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DCUN1D3	NAE1	ENSECAP00000015551	ENSECAP00000038752	DCN1-like protein.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.666
DCUN1D3	NEDD8	ENSECAP00000015551	ENSECAP00000040498	DCN1-like protein.	NEDD8 ubiquitin like modifier.	0.800
DCUN1D3	UBA3	ENSECAP00000015551	ENSECAP00000043479	DCN1-like protein.	Ubiquitin like modifier activating enzyme 3.	0.726
DCUN1D3	UBE2F	ENSECAP00000015551	ENSECAP00000009495	DCN1-like protein.	Ubiquitin conjugating enzyme E2 F (putative); Belongs to the ubiquitin-conjugating enzyme family.	0.911
DCUN1D3	UBE2M	ENSECAP00000015551	ENSECAP00000011238	DCN1-like protein.	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family.	0.818
NAE1	DCUN1D3	ENSECAP00000038752	ENSECAP00000015551	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	DCN1-like protein.	0.666
NAE1	NEDD8	ENSECAP00000038752	ENSECAP00000040498	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	NEDD8 ubiquitin like modifier.	0.993
NAE1	UBA3	ENSECAP00000038752	ENSECAP00000043479	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	Ubiquitin like modifier activating enzyme 3.	0.999
NAE1	UBE2F	ENSECAP00000038752	ENSECAP00000009495	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	Ubiquitin conjugating enzyme E2 F (putative); Belongs to the ubiquitin-conjugating enzyme family.	0.926
NAE1	UBE2M	ENSECAP00000038752	ENSECAP00000011238	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family.	0.974
NEDD8	DCUN1D3	ENSECAP00000040498	ENSECAP00000015551	NEDD8 ubiquitin like modifier.	DCN1-like protein.	0.800
NEDD8	NAE1	ENSECAP00000040498	ENSECAP00000038752	NEDD8 ubiquitin like modifier.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.993
NEDD8	UBA3	ENSECAP00000040498	ENSECAP00000043479	NEDD8 ubiquitin like modifier.	Ubiquitin like modifier activating enzyme 3.	0.999
NEDD8	UBE2F	ENSECAP00000040498	ENSECAP00000009495	NEDD8 ubiquitin like modifier.	Ubiquitin conjugating enzyme E2 F (putative); Belongs to the ubiquitin-conjugating enzyme family.	0.986
NEDD8	UBE2M	ENSECAP00000040498	ENSECAP00000011238	NEDD8 ubiquitin like modifier.	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family.	0.998
UBA3	DCUN1D3	ENSECAP00000043479	ENSECAP00000015551	Ubiquitin like modifier activating enzyme 3.	DCN1-like protein.	0.726
UBA3	NAE1	ENSECAP00000043479	ENSECAP00000038752	Ubiquitin like modifier activating enzyme 3.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.999
UBA3	NEDD8	ENSECAP00000043479	ENSECAP00000040498	Ubiquitin like modifier activating enzyme 3.	NEDD8 ubiquitin like modifier.	0.999
UBA3	UBE2F	ENSECAP00000043479	ENSECAP00000009495	Ubiquitin like modifier activating enzyme 3.	Ubiquitin conjugating enzyme E2 F (putative); Belongs to the ubiquitin-conjugating enzyme family.	0.983
UBA3	UBE2M	ENSECAP00000043479	ENSECAP00000011238	Ubiquitin like modifier activating enzyme 3.	Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family.	0.996