STRINGSTRING
FZD1 FZD1 FZD10 FZD10 BAMBI BAMBI AMER1 AMER1 DVL2 DVL2 BCL9 BCL9 WNT2B WNT2B WNT16 WNT16 CTNNB1 CTNNB1 LRP6 LRP6 TCF7 TCF7 VANGL1 VANGL1 KREMEN1 KREMEN1 WNT5A WNT5A WNT1 WNT1 DVL3 DVL3 PRICKLE3 PRICKLE3 DAAM1 DAAM1 PYGO1 PYGO1 NLK NLK TLE4 TLE4 SFRP4 SFRP4 WNT6 WNT6 SOST SOST WNT7B WNT7B TLE1 TLE1 FZD6 FZD6 WNT8A WNT8A CER1 CER1 PYGO2 PYGO2 NKD1 NKD1 CELSR3 CELSR3 WNT5B WNT5B SFRP2 SFRP2 FRZB FRZB FZD2 FZD2 DKK1 DKK1 PRICKLE4 PRICKLE4 AXIN2 AXIN2 FZD3 FZD3 PRICKLE2 PRICKLE2 WNT4 WNT4 PRICKLE1 PRICKLE1 GSK3A GSK3A DVL1 DVL1 USP47 USP47 SFRP1 SFRP1 VANGL2 VANGL2 WNT3 WNT3 OGFR OGFR WNT11 WNT11 CTBP2 CTBP2 BNIP2 BNIP2 DKK3 DKK3 LRP10 LRP10 OGFRL1 OGFRL1 AXIN1 AXIN1 ROR1 ROR1 WNT2 WNT2 WIF1 WIF1 GSK3B GSK3B CCN4 CCN4 SFRP5 SFRP5 DKK4 DKK4 WNT3A WNT3A WNT10A WNT10A TCF7L2 TCF7L2 DKK2 DKK2 BCL9L BCL9L FZD5 FZD5 CTBP1 CTBP1 WNT8B WNT8B WNT7A WNT7A FRAT1 FRAT1 APC2 APC2 WNT10B WNT10B WLS WLS TCF7L1 TCF7L1 APC APC WNT9B WNT9B LRP5 LRP5 FZD8 FZD8 RYK RYK LEF1 LEF1 WNT9A WNT9A FRAT2 FRAT2 CELSR1 CELSR1 CSNK1A1 CSNK1A1 FZD7 FZD7 FZD4 FZD4 MECOM MECOM NKD2 NKD2 ANKRD6 ANKRD6 ROR2 ROR2 FBXW11 FBXW11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (595 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
AMER1APC membrane recruitment protein 1. (1126 aa)
DVL2Dishevelled segment polarity protein 2. (737 aa)
BCL9BCL9 transcription coactivator. (1398 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (495 aa)
CTNNB1Beta catenin 1. (781 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
TCF7Transcription factor 7. (650 aa)
VANGL1Vang-like protein. (524 aa)
KREMEN1Kremen protein; Receptor for Dickkopf proteins. Cooperates with DKK1/2 to inhibit Wnt/beta-catenin signaling by promoting the endocytosis of Wnt receptors LRP5 and LRP6. (458 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
DVL3Dishevelled segment polarity protein 3. (716 aa)
PRICKLE3Prickle planar cell polarity protein 3. (615 aa)
DAAM1Dishevelled associated activator of morphogenesis 1. (1078 aa)
PYGO1Pygopus family PHD finger 1. (419 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
TLE4TLE family member 4, transcriptional corepressor. (774 aa)
SFRP4Secreted frizzled related protein 4. (346 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
SOSTSclerostin. (213 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
TLE1TLE family member 1, transcriptional corepressor. (770 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
CER1Cerberus 1, DAN family BMP antagonist. (273 aa)
PYGO2Pygopus family PHD finger 2. (406 aa)
NKD1NKD inhibitor of WNT signaling pathway 1. (470 aa)
CELSR3Cadherin EGF LAG seven-pass G-type receptor 3; Belongs to the G-protein coupled receptor 2 family. (3316 aa)
WNT5BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
FRZBFrizzled related protein. (325 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
DKK1Dickkopf WNT signaling pathway inhibitor 1. (268 aa)
PRICKLE4Prickle planar cell polarity protein 4. (416 aa)
AXIN2Axin 2. (843 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
PRICKLE2Prickle planar cell polarity protein 2. (928 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
PRICKLE1Prickle planar cell polarity protein 1. (832 aa)
GSK3AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (483 aa)
DVL1Dishevelled segment polarity protein 1. (700 aa)
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1376 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
VANGL2Vang-like protein. (521 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (475 aa)
OGFROpioid growth factor receptor. (605 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
CTBP2C-terminal binding protein 2. (980 aa)
BNIP2BCL2 interacting protein 2. (375 aa)
DKK3Dickkopf WNT signaling pathway inhibitor 3. (467 aa)
LRP10LDL receptor related protein 10. (713 aa)
OGFRL1Opioid growth factor receptor like 1. (452 aa)
AXIN1Axin 1. (939 aa)
ROR1Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (937 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
WIF1WNT inhibitory factor 1. (379 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (440 aa)
CCN4Cellular communication network factor 4. (368 aa)
SFRP5Secreted frizzled related protein 5. (315 aa)
DKK4Dickkopf WNT signaling pathway inhibitor 4. (222 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
TCF7L2Transcription factor 7 like 2. (669 aa)
DKK2Dickkopf WNT signaling pathway inhibitor 2. (259 aa)
BCL9LBCL9 like. (1498 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (577 aa)
CTBP1C-terminal binding protein 1. (655 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (351 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (379 aa)
FRAT1Uncharacterized protein. (278 aa)
APC2APC regulator of WNT signaling pathway 2. (2301 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WLSWnt ligand secretion mediator. (541 aa)
TCF7L1Transcription factor 7 like 1. (758 aa)
APCAPC regulator of WNT signaling pathway. (2873 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
FZD8Frizzled class receptor 8; Belongs to the G-protein coupled receptor Fz/Smo family. (606 aa)
RYKReceptor like tyrosine kinase. (611 aa)
LEF1Lymphoid enhancer binding factor 1. (413 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
FRAT2FRAT regulator of WNT signaling pathway 2. (233 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (3076 aa)
CSNK1A1Casein kinase 1 alpha 1; Belongs to the protein kinase superfamily. (380 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
MECOMMDS1 and EVI1 complex locus. (1230 aa)
NKD2NKD inhibitor of WNT signaling pathway 2. (553 aa)
ANKRD6Ankyrin repeat domain 6. (797 aa)
ROR2Receptor tyrosine kinase like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (940 aa)
FBXW11F-box and WD repeat domain containing 11. (542 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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