(16 nodes) Mixed, incl. Lysophosphatidic acid receptor activity, and Protease-activated receptor network (Equus caballus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	P2RY1	Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family. (374 aa)
	F2RL1	F2R like trypsin receptor 1. (397 aa)
	F2RL3	F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. (394 aa)
	F2R	Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (428 aa)
	LPAR6	Oleoyl-L-alpha-lysophosphatidic acid recepto-like protein; Belongs to the G-protein coupled receptor 1 family. (344 aa)
	ADORA2B	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (333 aa)
	LPAR2	Lysophosphatidic acid receptor 2; Belongs to the G-protein coupled receptor 1 family. (351 aa)
	F2RL2	Coagulation factor II thrombin receptor like 2. (378 aa)
	LOC100049983	Uncharacterized protein; Belongs to the peptidase S1 family. (246 aa)
	LOC100055297	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (247 aa)
	LPAR1	Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
	LOC100068275	C-type lectin domain-containing protein. (175 aa)
	ADORA2A	Adenosine receptor A2a; Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). (412 aa)
	LPAR5	Lysophosphatidic acid receptor 5; Belongs to the G-protein coupled receptor 1 family. (371 aa)
	LOC100050112	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (257 aa)
	LPAR4	Lysophosphatidic acid receptor 4; Belongs to the G-protein coupled receptor 1 family. (370 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADORA2A	ADORA2B	ENSECAP00000024432	ENSECAP00000006467	Adenosine receptor A2a; Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	0.923
ADORA2A	F2R	ENSECAP00000024432	ENSECAP00000002827	Adenosine receptor A2a; Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).	Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family.	0.909
ADORA2A	F2RL3	ENSECAP00000024432	ENSECAP00000002393	Adenosine receptor A2a; Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).	F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family.	0.904
ADORA2A	LPAR1	ENSECAP00000024432	ENSECAP00000014255	Adenosine receptor A2a; Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).	Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.900
ADORA2A	LPAR2	ENSECAP00000024432	ENSECAP00000007144	Adenosine receptor A2a; Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).	Lysophosphatidic acid receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.905
ADORA2A	LPAR4	ENSECAP00000024432	ENSECAP00000052197	Adenosine receptor A2a; Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).	Lysophosphatidic acid receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.909
ADORA2A	LPAR5	ENSECAP00000024432	ENSECAP00000025235	Adenosine receptor A2a; Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).	Lysophosphatidic acid receptor 5; Belongs to the G-protein coupled receptor 1 family.	0.903
ADORA2A	P2RY1	ENSECAP00000024432	ENSECAP00000001242	Adenosine receptor A2a; Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).	Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family.	0.918
ADORA2B	ADORA2A	ENSECAP00000006467	ENSECAP00000024432	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	Adenosine receptor A2a; Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).	0.923
ADORA2B	F2R	ENSECAP00000006467	ENSECAP00000002827	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family.	0.905
ADORA2B	F2RL3	ENSECAP00000006467	ENSECAP00000002393	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family.	0.913
ADORA2B	LPAR1	ENSECAP00000006467	ENSECAP00000014255	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.900
ADORA2B	LPAR2	ENSECAP00000006467	ENSECAP00000007144	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	Lysophosphatidic acid receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.905
ADORA2B	LPAR4	ENSECAP00000006467	ENSECAP00000052197	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	Lysophosphatidic acid receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.909
ADORA2B	LPAR5	ENSECAP00000006467	ENSECAP00000025235	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	Lysophosphatidic acid receptor 5; Belongs to the G-protein coupled receptor 1 family.	0.903
ADORA2B	P2RY1	ENSECAP00000006467	ENSECAP00000001242	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	Purinergic receptor P2Y1; Belongs to the G-protein coupled receptor 1 family.	0.923
F2R	ADORA2A	ENSECAP00000002827	ENSECAP00000024432	Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family.	Adenosine receptor A2a; Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity).	0.909
F2R	ADORA2B	ENSECAP00000002827	ENSECAP00000006467	Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family.	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.	0.905
F2R	F2RL3	ENSECAP00000002827	ENSECAP00000002393	Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family.	F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family.	0.929
F2R	LOC100049983	ENSECAP00000002827	ENSECAP00000012520	Coagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein; Belongs to the peptidase S1 family.	0.727