(8 nodes) Mixed, incl. Hsp90 protein, and Cdc37 network (Equus caballus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	STIP1	Stress induced phosphoprotein 1. (543 aa)
	HSP90AB1	Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] (730 aa)
	AHSA1	Activator of HSP90 ATPase activity 1. (339 aa)
	CDC37	Cell division cycle 37. (379 aa)
	SUGT1	SGT1 homolog, MIS12 kinetochore complex assembly cochaperone. (337 aa)
	HSPA4	Heat shock protein family A (Hsp70) member 4. (840 aa)
	DNAJC7	DnaJ heat shock protein family (Hsp40) member C7. (543 aa)
	TRAP1	TNF receptor associated protein 1. (702 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHSA1	CDC37	ENSECAP00000009808	ENSECAP00000010796	Activator of HSP90 ATPase activity 1.	Cell division cycle 37.	0.578
AHSA1	DNAJC7	ENSECAP00000009808	ENSECAP00000036033	Activator of HSP90 ATPase activity 1.	DnaJ heat shock protein family (Hsp40) member C7.	0.595
AHSA1	HSP90AB1	ENSECAP00000009808	ENSECAP00000006887	Activator of HSP90 ATPase activity 1.	Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...]	0.695
AHSA1	HSPA4	ENSECAP00000009808	ENSECAP00000019150	Activator of HSP90 ATPase activity 1.	Heat shock protein family A (Hsp70) member 4.	0.551
AHSA1	STIP1	ENSECAP00000009808	ENSECAP00000005375	Activator of HSP90 ATPase activity 1.	Stress induced phosphoprotein 1.	0.825
AHSA1	SUGT1	ENSECAP00000009808	ENSECAP00000010916	Activator of HSP90 ATPase activity 1.	SGT1 homolog, MIS12 kinetochore complex assembly cochaperone.	0.728
AHSA1	TRAP1	ENSECAP00000009808	ENSECAP00000037781	Activator of HSP90 ATPase activity 1.	TNF receptor associated protein 1.	0.658
CDC37	AHSA1	ENSECAP00000010796	ENSECAP00000009808	Cell division cycle 37.	Activator of HSP90 ATPase activity 1.	0.578
CDC37	HSP90AB1	ENSECAP00000010796	ENSECAP00000006887	Cell division cycle 37.	Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...]	0.973
CDC37	HSPA4	ENSECAP00000010796	ENSECAP00000019150	Cell division cycle 37.	Heat shock protein family A (Hsp70) member 4.	0.549
CDC37	STIP1	ENSECAP00000010796	ENSECAP00000005375	Cell division cycle 37.	Stress induced phosphoprotein 1.	0.880
CDC37	TRAP1	ENSECAP00000010796	ENSECAP00000037781	Cell division cycle 37.	TNF receptor associated protein 1.	0.774
DNAJC7	AHSA1	ENSECAP00000036033	ENSECAP00000009808	DnaJ heat shock protein family (Hsp40) member C7.	Activator of HSP90 ATPase activity 1.	0.595
DNAJC7	HSP90AB1	ENSECAP00000036033	ENSECAP00000006887	DnaJ heat shock protein family (Hsp40) member C7.	Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...]	0.730
DNAJC7	HSPA4	ENSECAP00000036033	ENSECAP00000019150	DnaJ heat shock protein family (Hsp40) member C7.	Heat shock protein family A (Hsp70) member 4.	0.742
DNAJC7	SUGT1	ENSECAP00000036033	ENSECAP00000010916	DnaJ heat shock protein family (Hsp40) member C7.	SGT1 homolog, MIS12 kinetochore complex assembly cochaperone.	0.563
DNAJC7	TRAP1	ENSECAP00000036033	ENSECAP00000037781	DnaJ heat shock protein family (Hsp40) member C7.	TNF receptor associated protein 1.	0.552
HSP90AB1	AHSA1	ENSECAP00000006887	ENSECAP00000009808	Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...]	Activator of HSP90 ATPase activity 1.	0.695
HSP90AB1	CDC37	ENSECAP00000006887	ENSECAP00000010796	Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...]	Cell division cycle 37.	0.973
HSP90AB1	DNAJC7	ENSECAP00000006887	ENSECAP00000036033	Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...]	DnaJ heat shock protein family (Hsp40) member C7.	0.730