(16 nodes) Nuclear membrane protein complex, and Breakdown of the nuclear lamina network (Equus caballus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LMNB1	Lamin B1; Belongs to the intermediate filament family. (586 aa)
	LMNA	Lamin A/C; Belongs to the intermediate filament family. (663 aa)
	SYNE3	Spectrin repeat containing nuclear envelope family member 3. (975 aa)
	CASP6	Caspase 6; Belongs to the peptidase C14A family. (275 aa)
	DFFA	DNA fragmentation factor subunit alpha. (334 aa)
	SUN1	Sad1 and UNC84 domain containing 1. (948 aa)
	SPAG4	Sperm associated antigen 4. (538 aa)
	CCDC155	Coiled-coil domain containing 155. (566 aa)
	SYNE1	Spectrin repeat containing nuclear envelope protein 1. (8798 aa)
	SYNE4	Spectrin repeat containing nuclear envelope family member 4. (549 aa)
	LMNB2	Lamin B2; Belongs to the intermediate filament family. (659 aa)
	SUN2	Sad1 and UNC84 domain containing 2. (743 aa)
	SYNE2	Spectrin repeat containing nuclear envelope protein 2. (6914 aa)
	LOC100049805	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (302 aa)
	LRMP	Lymphoid restricted membrane protein. (1453 aa)
	LOC111767413	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (252 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP6	LMNA	ENSECAP00000013268	ENSECAP00000009322	Caspase 6; Belongs to the peptidase C14A family.	Lamin A/C; Belongs to the intermediate filament family.	0.990
CASP6	LMNB1	ENSECAP00000013268	ENSECAP00000006401	Caspase 6; Belongs to the peptidase C14A family.	Lamin B1; Belongs to the intermediate filament family.	0.988
CASP6	LMNB2	ENSECAP00000013268	ENSECAP00000031151	Caspase 6; Belongs to the peptidase C14A family.	Lamin B2; Belongs to the intermediate filament family.	0.956
CCDC155	SUN1	ENSECAP00000022012	ENSECAP00000015320	Coiled-coil domain containing 155.	Sad1 and UNC84 domain containing 1.	0.961
CCDC155	SUN2	ENSECAP00000022012	ENSECAP00000032847	Coiled-coil domain containing 155.	Sad1 and UNC84 domain containing 2.	0.935
CCDC155	SYNE1	ENSECAP00000022012	ENSECAP00000022805	Coiled-coil domain containing 155.	Spectrin repeat containing nuclear envelope protein 1.	0.663
CCDC155	SYNE2	ENSECAP00000022012	ENSECAP00000045856	Coiled-coil domain containing 155.	Spectrin repeat containing nuclear envelope protein 2.	0.659
CCDC155	SYNE3	ENSECAP00000022012	ENSECAP00000012937	Coiled-coil domain containing 155.	Spectrin repeat containing nuclear envelope family member 3.	0.568
CCDC155	SYNE4	ENSECAP00000022012	ENSECAP00000029605	Coiled-coil domain containing 155.	Spectrin repeat containing nuclear envelope family member 4.	0.673
DFFA	LOC100049805	ENSECAP00000015281	ENSECAP00000047892	DNA fragmentation factor subunit alpha.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.900
DFFA	LOC111767413	ENSECAP00000015281	ENSECAP00000053464	DNA fragmentation factor subunit alpha.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.900
LMNA	CASP6	ENSECAP00000009322	ENSECAP00000013268	Lamin A/C; Belongs to the intermediate filament family.	Caspase 6; Belongs to the peptidase C14A family.	0.990
LMNA	LMNB1	ENSECAP00000009322	ENSECAP00000006401	Lamin A/C; Belongs to the intermediate filament family.	Lamin B1; Belongs to the intermediate filament family.	0.993
LMNA	LMNB2	ENSECAP00000009322	ENSECAP00000031151	Lamin A/C; Belongs to the intermediate filament family.	Lamin B2; Belongs to the intermediate filament family.	0.987
LMNA	LOC100049805	ENSECAP00000009322	ENSECAP00000047892	Lamin A/C; Belongs to the intermediate filament family.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.904
LMNA	LOC111767413	ENSECAP00000009322	ENSECAP00000053464	Lamin A/C; Belongs to the intermediate filament family.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.904
LMNA	SPAG4	ENSECAP00000009322	ENSECAP00000019432	Lamin A/C; Belongs to the intermediate filament family.	Sperm associated antigen 4.	0.442
LMNA	SUN1	ENSECAP00000009322	ENSECAP00000015320	Lamin A/C; Belongs to the intermediate filament family.	Sad1 and UNC84 domain containing 1.	0.924
LMNA	SUN2	ENSECAP00000009322	ENSECAP00000032847	Lamin A/C; Belongs to the intermediate filament family.	Sad1 and UNC84 domain containing 2.	0.948
LMNA	SYNE1	ENSECAP00000009322	ENSECAP00000022805	Lamin A/C; Belongs to the intermediate filament family.	Spectrin repeat containing nuclear envelope protein 1.	0.885