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| | MMP9 | Matrix metallopeptidase 9. (714 aa) |
| | ENPP1 | Ectonucleotide pyrophosphatase/phosphodiesterase 1. (1043 aa) |
| | TMEM38B | Transmembrane protein 38B. (400 aa) |
| | SOST | Sclerostin. (213 aa) |
| | KLF10 | Kruppel like factor 10. (514 aa) |
| | THBS3 | Thrombospondin 3. (956 aa) |
| | GDF2 | Growth differentiation factor 2. (427 aa) |
| | NPR2 | Guanylate cyclase. (1065 aa) |
| | CHRDL2 | Chordin like 2. (454 aa) |
| | PHEX | Phosphate regulating endopeptidase homolog X-linked. (749 aa) |
| | TGFB1 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa) |
| | TAPT1 | Transmembrane anterior posterior transformation 1. (643 aa) |
| | GLI1 | GLI family zinc finger 1. (1106 aa) |
| | TP53INP2 | Tumor protein p53 inducible nuclear protein 2. (221 aa) |
| | TCIRG1 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa) |
| | MGP | Matrix Gla protein; Associates with the organic matrix of bone and cartilage. (103 aa) |
| | DHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa) |
| | GATA1 | GATA binding protein 1. (486 aa) |
| | MYOC | Myocilin. (490 aa) |
| | SEMA4D | Semaphorin 4D; Belongs to the semaphorin family. (862 aa) |
| | SNAI2 | Snail family transcriptional repressor 2. (268 aa) |
| | TBC1D31 | TBC1 domain family member 31. (1067 aa) |
| | GPC3 | Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (611 aa) |
| | SNAI1 | Snail family transcriptional repressor 1. (265 aa) |
| | IFT80 | Intraflagellar transport 80. (777 aa) |
| | GDF10 | Bone morphogenetic protein 3; Belongs to the TGF-beta family. (477 aa) |
| | HAND2 | Heart and neural crest derivatives expressed 2. (217 aa) |
| | NF1 | Neurofibromin 1. (3024 aa) |
| | GIT1 | GIT ArfGAP 1. (770 aa) |
| | CCDC154 | Coiled-coil domain containing 154. (524 aa) |
| | FIGNL1 | Fidgetin like 1; Belongs to the AAA ATPase family. (677 aa) |
| | PTH1R | Parathyroid hormone 1 receptor; Belongs to the G-protein coupled receptor 2 family. (586 aa) |
| | EPHA2 | EPH receptor A2. (975 aa) |
| | CLEC5A | C-type lectin domain containing 5A. (156 aa) |
| | MMP14 | Matrix metallopeptidase 14. (581 aa) |
| | SBDS | SBDS ribosome maturation factor. (250 aa) |
| | ZMPSTE24 | CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa) |
| | LOC111774036 | Histone H3; Belongs to the histone H3 family. (136 aa) |
| | FGR | Tyrosine-protein kinase. (527 aa) |
| | PEX7 | Peroxisomal biogenesis factor 7. (319 aa) |
| | ASPN | Asporin. (370 aa) |
| | MMP13 | Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...] (472 aa) |
| | ATF4 | Activating transcription factor 4. (334 aa) |
| | NAB2 | NGFI-A binding protein 2. (716 aa) |
| | RUNX1 | RUNX family transcription factor 1. (537 aa) |
| | DMP1 | Dentin matrix acidic phosphoprotein 1. (519 aa) |
| | IHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa) |
| | JUNB | JunB proto-oncogene, AP-1 transcription factor subunit. (347 aa) |
| | FSTL3 | Follistatin like 3. (262 aa) |
| | CALCR | Calcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (475 aa) |
| | ADAR | Adenosine deaminase RNA specific. (1171 aa) |
| | FZD1 | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (595 aa) |
| | TMEM119 | Transmembrane protein 119. (275 aa) |
| | NPPC | Natriuretic peptide C. (126 aa) |
| | FBXL15 | F-box and leucine rich repeat protein 15. (347 aa) |
| | HOXA2 | Homeobox A2. (458 aa) |
| | SMPD3 | Sphingomyelin phosphodiesterase 3. (658 aa) |
| | BGLAP | Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. (100 aa) |
| | UCMA | Upper zone of growth plate and cartilage matrix associated. (172 aa) |
| | IBSP | Integrin binding sialoprotein. (310 aa) |
| | CCN1 | Cellular communication network factor 1. (382 aa) |
| | COL1A2 | Collagen type I alpha 2 chain. (1364 aa) |
| | CCN4 | Cellular communication network factor 4. (368 aa) |
| | DHX36 | DEAH-box helicase 36. (1029 aa) |
| | BMPR2 | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa) |
| | CYP27B1 | Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa) |
| | CLEC3B | C-type lectin domain family 3 member B. (262 aa) |
| | WNT3A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa) |
| | RUNX3 | Runt-related transcription factor; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. (433 aa) |
| | SATB2 | DNA-binding protein SATB. (733 aa) |
| | HDAC4 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1170 aa) |
| | MEF2C | Myocyte enhancer factor 2C. (483 aa) |
| | LTBP3 | Latent transforming growth factor beta binding protein 3. (1554 aa) |
| | PTN | Pleiotrophin. (192 aa) |
| | LOC100054462 | Histone domain-containing protein. (444 aa) |
| | FGF18 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa) |
| | SMO | Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa) |
| | RUNX2 | Runt-related transcription factor 2; Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. Inhibits KAT6B-dependent transcriptional activation. In osteoblasts, supports transcription activati [...] (634 aa) |
| | ERCC2 | ERCC excision repair 2, TFIIH core complex helicase subunit. (769 aa) |
| | TGFB3 | Transforming growth factor beta 3. (490 aa) |
| | PHOSPHO2 | Phosphatase, orphan 2. (241 aa) |
| | IMPAD1 | Inositol monophosphatase domain containing 1. (360 aa) |
| | WNT10B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa) |
| | JUND | JunD proto-oncogene, AP-1 transcription factor subunit. (349 aa) |
| | IGF1 | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa) |
| | DBN1 | Drebrin 1. (706 aa) |
| | LTF | Lactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites. (715 aa) |
| | ANKH | ANKH inorganic pyrophosphate transport regulator. (864 aa) |
| | ALPL | Alkaline phosphatase. (574 aa) |
| | SP3 | Sp3 transcription factor. (790 aa) |
| | LRP5 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa) |
| | COMP | Cartilage oligomeric matrix protein. (793 aa) |
| | LEF1 | Lymphoid enhancer binding factor 1. (413 aa) |
| | MAP2K6 | Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (363 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog. (425 aa) |
| | GPLD1 | Glycosylphosphatidylinositol specific phospholipase D1. (867 aa) |
| | WWTR1 | WW domain containing transcription regulator 1. (400 aa) |
| | COL13A1 | Collagen type XIII alpha 1 chain. (716 aa) |
| | SBNO2 | Strawberry notch homolog 2. (1370 aa) |
| | EIF2AK3 | Eukaryotic translation initiation factor 2 alpha kinase 3. (1189 aa) |
| | NOG | Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa) |
| | CSGALNACT1 | Hexosyltransferase. (532 aa) |
| | TNN | Tenascin N. (1296 aa) |
| | IFITM5 | Interferon induced transmembrane protein 5. (208 aa) |
| | GLI3 | GLI family zinc finger 3. (1581 aa) |
| | CLEC11A | C-type lectin domain containing 11A. (324 aa) |
| | SNX10 | Sorting nexin 10. (201 aa) |
| | BMPR1B | Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (547 aa) |
| | SOX8 | SRY-box 8. (460 aa) |
| | CCL3 | SCY domain-containing protein. (226 aa) |
| | COL2A1 | Collagen type II alpha 1 chain. (1487 aa) |
| | HIF1A | Hypoxia inducible factor 1 subunit alpha. (844 aa) |
| | TNFRSF11A | TNF receptor superfamily member 11a. (647 aa) |
| | VCAN | Versican. (3400 aa) |
| | IGF2 | Insulin-like growth factor II; The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF-II is influenced by placental lactogen. Also involved in tissue differentiation. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is r [...] (450 aa) |
| | EXT2 | Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (750 aa) |
| | COL1A1 | Collagen type I alpha 1 chain. (1521 aa) |
| | MMP16 | Matrix metallopeptidase 16. (622 aa) |
| | SLC24A3 | Solute carrier family 24 member 3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (644 aa) |
| | PTHLH | Parathyroid hormone-related protein; Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity o [...] (177 aa) |
| | CLEC3A | C-type lectin domain family 3 member A. (196 aa) |
| | FGF2 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa) |
| | LOX | Lysyl oxidase. (481 aa) |
| | CER1 | Cerberus 1, DAN family BMP antagonist. (273 aa) |
| | CBFB | Core-binding factor subunit beta. (188 aa) |
| | WWOX | WW domain containing oxidoreductase. (422 aa) |
| | GLIS1 | GLIS family zinc finger 1. (795 aa) |
| | ASF1A | Anti-silencing function 1A histone chaperone. (204 aa) |
| | PHOSPHO1 | Phosphoethanolamine/phosphocholine phosphatase. (360 aa) |
| | CYP24A1 | Cytochrome P450 family 24 subfamily A member 1; Belongs to the cytochrome P450 family. (514 aa) |
| | TNFSF11 | Tumor necrosis factor ligand superfamily member. (318 aa) |
| | CCN2 | Cellular communication network factor 2. (475 aa) |
| | ENSECAP00000014555 | H3 histone family member 3B. (136 aa) |
| | SPP1 | Secreted phosphoprotein 1. (313 aa) |
| | CYP27C1 | Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (547 aa) |
| | BMP4 | Bone morphogenetic protein 4. (409 aa) |
| | ATP6V0A4 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (862 aa) |
| | IGFBP3 | Insulin like growth factor binding protein 3. (299 aa) |
| | TWSG1 | Twisted gastrulation BMP signaling modulator 1. (223 aa) |
| | AXIN2 | Axin 2. (843 aa) |
| | MESD | Mesoderm development LRP chaperone. (230 aa) |
| | SMAD5 | Mothers against decapentaplegic homolog. (465 aa) |
| | FGF9 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa) |
| | MN1 | MN1 proto-oncogene, transcriptional regulator. (1306 aa) |
| | SIRT7 | Sirtuin 7. (400 aa) |
| | PTH | Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D- glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity). (115 aa) |
| | DLX5 | Distal-less homeobox 5. (289 aa) |
| | PPARGC1B | PPARG coactivator 1 beta. (1239 aa) |
| | BMP6 | Bone morphogenetic protein 6. (506 aa) |
| | SP7 | Sp7 transcription factor. (431 aa) |
| | MYF5 | Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa) |
| | CTHRC1 | Collagen triple helix repeat containing 1. (244 aa) |
| | MEF2D | Myocyte enhancer factor 2D. (517 aa) |
| | BMPR1A | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (564 aa) |
| | BMP2 | Bone morphogenetic protein 2. (397 aa) |
| | SFRP1 | Secreted frizzled related protein 1. (314 aa) |
| | WNT3 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (475 aa) |
| | LOC100146156 | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (607 aa) |
| | SOX9 | SRY-box 9. (509 aa) |
| | FHL2 | Four and a half LIM domains 2. (279 aa) |
| | EBP | 3-beta-hydroxysteroid-Delta(8) Delta(7)-isomerase-like protein. (230 aa) |
| | WNT11 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa) |
| | PDLIM7 | PDZ and LIM domain 7. (458 aa) |
| | ATP6V1B1 | Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (513 aa) |
| | SMAD1 | Mothers against decapentaplegic homolog. (465 aa) |
| | LOC100057612 | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (555 aa) |
| | SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa) |
| | EXT1 | Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa) |
| | SLC26A2 | Sulfate transporter; Sulfate transporter. May play a role in endochondral bone formation; Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (736 aa) |
| | PKDCC | Protein kinase domain containing, cytoplasmic. (493 aa) |
| | RASSF2 | Ras association domain family member 2. (326 aa) |
| | BMP3 | Bone morphogenetic protein 3. (522 aa) |
| | LGR4 | Leucine rich repeat containing G protein-coupled receptor 4. (1108 aa) |
