STRINGSTRING
VPS18 VPS18 PRKN PRKN APBA1 APBA1 SCRIB SCRIB GABRA2 GABRA2 TH TH CACNB2 CACNB2 RHOD RHOD FBXL20 FBXL20 GPM6B GPM6B SYN3 SYN3 RIMS1 RIMS1 CACNB4 CACNB4 VAMP2 VAMP2 STXBP1 STXBP1 UNC13B UNC13B SYT9 SYT9 GAD2 GAD2 BCHE BCHE GPER1 GPER1 MAOB MAOB STX19 STX19 HCRT HCRT LIN7A LIN7A SYN1 SYN1 SYN2 SYN2 ADRA2A ADRA2A SYT5 SYT5 RAP1B RAP1B CPLX3 CPLX3 LOC100049912 LOC100049912 OTOF OTOF SLC5A7 SLC5A7 PREPL PREPL SLC6A11 SLC6A11 SNAP23 SNAP23 GIT1 GIT1 NF1 NF1 LOC100055638 LOC100055638 SLC44A4 SLC44A4 P2RX7 P2RX7 GFAP GFAP GIPC2 GIPC2 PDZD11 PDZD11 LRRK2 LRRK2 SYT2 SYT2 STX4 STX4 SLC29A2 SLC29A2 LOC100049849 LOC100049849 FSHR FSHR BACE1 BACE1 GRIN3A GRIN3A SYT1 SYT1 DAGLB DAGLB GAD1 GAD1 PNKD PNKD STX3 STX3 SLC18A1 SLC18A1 TOR1A TOR1A SLC17A8 SLC17A8 CASK CASK CPLX2 CPLX2 STX2 STX2 SYP SYP RAB3B RAB3B LIN7C LIN7C RAP1A RAP1A SLC22A1 SLC22A1 PARK7 PARK7 STXBP2 STXBP2 MOXD1 MOXD1 SLC6A4 SLC6A4 NT5DC3 NT5DC3 DOC2A DOC2A ITGB3 ITGB3 DBH DBH LIN7B LIN7B SNAPIN SNAPIN ALDH5A1 ALDH5A1 DVL1 DVL1 RIMS3 RIMS3 STXBP3 STXBP3 CHRNA5 CHRNA5 SLC22A2 SLC22A2 CHAT CHAT FLOT1 FLOT1 CTBP2 CTBP2 SLC1A7 SLC1A7 SNAP25 SNAP25 RAB3A RAB3A STX1A STX1A ABAT ABAT SLC18A2 SLC18A2 CADPS2 CADPS2 PRRT2 PRRT2 SLC6A3 SLC6A3 GSK3B GSK3B ADCY1 ADCY1 DGKI DGKI SNAP47 SNAP47 SLC4A8 SLC4A8 DOC2B DOC2B RPH3A RPH3A SNTN SNTN UNC13C UNC13C BRAF BRAF ERC2 ERC2 PFN2 PFN2 RPH3AL RPH3AL STXBP5 STXBP5 AGTPBP1 AGTPBP1 MCTP2 MCTP2 SLC29A4 SLC29A4 STXBP5L STXBP5L LRRC1 LRRC1 RIMS2 RIMS2 SNAP29 SNAP29 SLC22A3 SLC22A3 SLC29A1 SLC29A1 PPFIA3 PPFIA3 GDNF GDNF SNCAIP SNCAIP CHRM2 CHRM2 DAGLA DAGLA ACTN1 ACTN1 LOC111772328 LOC111772328 RAB5A RAB5A PRIMA1 PRIMA1 DTNBP1 DTNBP1 GIPC3 GIPC3 LOC100146569 LOC100146569 ACHE ACHE PRKCB PRKCB STX11 STX11 SLC1A2 SLC1A2 MAOA MAOA STX1B STX1B UNC13A UNC13A GIPC1 GIPC1 CADPS CADPS SYT8 SYT8 SLC6A2 SLC6A2 NT5DC2 NT5DC2 ITGB1 ITGB1 NLGN1 NLGN1 MCTP1 MCTP1 COMT COMT
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VPS18VPS18 core subunit of CORVET and HOPS complexes. (976 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (466 aa)
APBA1Amyloid beta precursor protein binding family A member 1. (843 aa)
SCRIBScribble planar cell polarity protein. (1690 aa)
GABRA2Gamma-aminobutyric acid type A receptor alpha2 subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (511 aa)
THTyrosine hydroxylase. (526 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (660 aa)
RHODSynaptotagmin 12. (530 aa)
FBXL20F-box and leucine rich repeat protein 20. (438 aa)
GPM6BGlycoprotein M6B. (328 aa)
SYN3Synapsin III. (580 aa)
RIMS1Regulating synaptic membrane exocytosis 1. (1681 aa)
CACNB4Calcium voltage-gated channel auxiliary subunit beta 4. (519 aa)
VAMP2V-SNARE coiled-coil homology domain-containing protein. (118 aa)
STXBP1Syntaxin binding protein 1; Belongs to the STXBP/unc-18/SEC1 family. (619 aa)
UNC13BUnc-13 homolog B. (4269 aa)
SYT9Olfactomedin like 1. (848 aa)
GAD2Glutamate decarboxylase 2. (585 aa)
BCHECholinesterase; Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters (By similarity). (681 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
MAOBAmine oxidase. (520 aa)
STX19Syntaxin 19; Belongs to the syntaxin family. (294 aa)
HCRTOrexin; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Belongs to the orexin family. (130 aa)
LIN7AProtein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (233 aa)
SYN1Synapsin I. (670 aa)
SYN2Peroxisome proliferator activated receptor gamma. (586 aa)
ADRA2AAdrenoceptor alpha 2A. (465 aa)
SYT5Synaptotagmin 5. (386 aa)
RAP1BRas-related protein Rap-1b-like protein. (184 aa)
CPLX3Complexin 3. (158 aa)
LOC100049912Uncharacterized protein. (184 aa)
OTOFOtoferlin. (1996 aa)
SLC5A7Solute carrier family 5 member 7; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (579 aa)
PREPLProlyl endopeptidase like. (727 aa)
SLC6A11Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (633 aa)
SNAP23Synaptosomal-associated protein; Belongs to the SNAP-25 family. (211 aa)
GIT1GIT ArfGAP 1. (770 aa)
NF1Neurofibromin 1. (3024 aa)
LOC100055638Uncharacterized protein. (513 aa)
SLC44A4Solute carrier family 44 member 4; Belongs to the CTL (choline transporter-like) family. (708 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (559 aa)
GIPC2GIPC PDZ domain containing family member 2. (314 aa)
PDZD11PDZ domain-containing protein 11-like protein. (140 aa)
LRRK2Leucine rich repeat kinase 2. (2528 aa)
SYT2Synaptotagmin 2. (419 aa)
STX4Syntaxin 4; Belongs to the syntaxin family. (297 aa)
SLC29A2Solute carrier family 29 member 2. (452 aa)
LOC100049849DOMON domain-containing protein. (625 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (694 aa)
BACE1Beta-secretase 1; Belongs to the peptidase A1 family. (501 aa)
GRIN3AGlutamate ionotropic receptor NMDA type subunit 3A. (1115 aa)
SYT1Synaptotagmin 1. (422 aa)
DAGLBDiacylglycerol lipase beta. (672 aa)
GAD1Glutamate decarboxylase 1. (594 aa)
PNKDPNKD metallo-beta-lactamase domain containing. (385 aa)
STX3Syntaxin 3; Belongs to the syntaxin family. (306 aa)
SLC18A1Solute carrier family 18 member A1. (525 aa)
TOR1ATorsin family 1 member A. (378 aa)
SLC17A8Solute carrier family 17 member 8. (598 aa)
CASKCalcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (926 aa)
CPLX2Complexin 2. (134 aa)
STX2Syntaxin 2; Belongs to the syntaxin family. (459 aa)
SYPSynaptophysin. (313 aa)
RAB3BRAB3B, member RAS oncogene family. (238 aa)
LIN7CProtein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (197 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
SLC22A1Solute carrier family 22 member 1. (554 aa)
PARK7Parkinsonism associated deglycase. (268 aa)
STXBP2Syntaxin binding protein 2; Belongs to the STXBP/unc-18/SEC1 family. (602 aa)
MOXD1Monooxygenase DBH like 1. (615 aa)
SLC6A4Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (630 aa)
NT5DC35'-nucleotidase domain containing 3. (546 aa)
DOC2ADouble C2-like domain-containing protein. (402 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
DBHSoluble dopamine beta-hydroxylase; Conversion of dopamine to noradrenaline. Belongs to the copper type II ascorbate-dependent monooxygenase family. (610 aa)
LIN7BLin-7 homolog B, crumbs cell polarity complex component. (294 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
ALDH5A1Aldehyde dehydrogenase 5 family member A1. (725 aa)
DVL1Dishevelled segment polarity protein 1. (700 aa)
RIMS3Regulating synaptic membrane exocytosis 3. (308 aa)
STXBP3Pre-mRNA processing factor 38B; Belongs to the STXBP/unc-18/SEC1 family. (1126 aa)
CHRNA5Cholinergic receptor nicotinic alpha 5 subunit. (468 aa)
SLC22A2Solute carrier family 22 member 2. (555 aa)
CHATCholine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (641 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
CTBP2C-terminal binding protein 2. (980 aa)
SLC1A7Amino acid transporter. (560 aa)
SNAP25Synaptosomal-associated protein; Belongs to the SNAP-25 family. (206 aa)
RAB3ARAB3A, member RAS oncogene family. (220 aa)
STX1ASyntaxin 1A; Belongs to the syntaxin family. (288 aa)
ABAT4-aminobutyrate aminotransferase. (604 aa)
SLC18A2Solute carrier family 18 member A2. (517 aa)
CADPS2Calcium dependent secretion activator 2. (1302 aa)
PRRT2Proline rich transmembrane protein 2. (340 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (617 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (440 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1124 aa)
DGKIDiacylglycerol kinase. (1078 aa)
SNAP47Synaptosome associated protein 47. (551 aa)
SLC4A8Anion exchange protein. (1106 aa)
DOC2BDouble C2 domain beta. (431 aa)
RPH3ARabphilin 3A. (702 aa)
SNTNSynaptoporin. (416 aa)
UNC13CUnc-13 homolog C. (2216 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (793 aa)
ERC2ELKS/RAB6-interacting/CAST family member 2. (1055 aa)
PFN2Profilin; Belongs to the profilin family. (188 aa)
RPH3ALRabphilin 3A like (without C2 domains). (316 aa)
STXBP5Syntaxin binding protein 5. (1162 aa)
AGTPBP1ATP/GTP binding protein 1. (1278 aa)
MCTP2Multiple C2 and transmembrane domain containing 2. (886 aa)
SLC29A4Solute carrier family 29 member 4. (617 aa)
STXBP5LSyntaxin binding protein 5 like. (1234 aa)
LRRC1Leucine rich repeat containing 1. (614 aa)
RIMS2Regulating synaptic membrane exocytosis 2. (1645 aa)
SNAP29Synaptosome associated protein 29. (258 aa)
SLC22A3Solute carrier family 22 member 3. (784 aa)
SLC29A1Solute carrier family 29 member 1. (455 aa)
PPFIA3PTPRF interacting protein alpha 3. (1194 aa)
GDNFGlial cell derived neurotrophic factor. (211 aa)
SNCAIPSynuclein alpha interacting protein. (982 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (496 aa)
DAGLADiacylglycerol lipase alpha. (1040 aa)
ACTN1Actinin alpha 1. (959 aa)
LOC111772328Glutamate decarboxylase 2. (585 aa)
RAB5ARAB5A, member RAS oncogene family. (215 aa)
PRIMA1Uncharacterized protein. (375 aa)
DTNBP1Dystrobrevin binding protein 1. (403 aa)
GIPC3GIPC PDZ domain containing family member 3. (312 aa)
LOC100146569C2 domain-containing protein. (387 aa)
ACHEAcetylcholinesterase (Cartwright blood group); Belongs to the type-B carboxylesterase/lipase family. (800 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
STX11Syntaxin 11. (325 aa)
SLC1A2Amino acid transporter. (646 aa)
MAOAAmine oxidase [flavin-containing] A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (By similarity). (922 aa)
STX1BSyntaxin 1B; Belongs to the syntaxin family. (288 aa)
UNC13AUnc-13 homolog A. (1726 aa)
GIPC1GIPC PDZ domain containing family member 1. (332 aa)
CADPSCalcium dependent secretion activator. (1432 aa)
SYT8Synaptotagmin 8. (453 aa)
SLC6A2Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (835 aa)
NT5DC25'-nucleotidase domain containing 2. (557 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (808 aa)
NLGN1Neuroligin 1. (823 aa)
MCTP1Multiple C2 and transmembrane domain containing 1. (997 aa)
COMTCatechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol (By similarity); Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. (393 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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