41 items (Equus caballus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LY96	Lymphocyte antigen 96. (173 aa)
	LOC111769983	BPI fold containing family A member 2. (249 aa)
	F7CF08_HORSE	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (98 aa)
	DEFB136	Uncharacterized protein. (73 aa)
	LOC111767791	CD14 molecule. (376 aa)
	PSMB4	Proteasome subunit beta 4. (309 aa)
	LOC100054193	Histone H2B; Belongs to the histone H2B family. (126 aa)
	HMGB1	High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...] (215 aa)
	TLR4	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (843 aa)
	P2RX7	P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
	LOC100072794	Uncharacterized protein. (557 aa)
	CD6	CD6 molecule. (673 aa)
	SELP	Selectin P. (829 aa)
	F2	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
	F6PQ40_HORSE	Proteasome subunit alpha type. (214 aa)
	ECATH-3	Myeloid cathelicidin 3. (170 aa)
	ZRANB2	Zinc finger Ran-binding domain-containing protein 2; May interfere with constitutive 5'-splice site selection. Belongs to the ZRANB2 family. (330 aa)
	NINJ1	Ninjurin 1. (223 aa)
	DROSHA	Drosha ribonuclease III. (1374 aa)
	LBP	Lipopolysaccharide binding protein. (481 aa)
	TREM2	Triggering receptor expressed on myeloid cells 2. (298 aa)
	ECATH-2	Myeloid cathelicidin 2. (157 aa)
	SCARB1	Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
	TRIL	TLR4 interactor with leucine rich repeats. (810 aa)
	LINGO3	Leucine rich repeat and Ig domain containing 3. (592 aa)
	NLRP6	NLR family pyrin domain containing 6. (892 aa)
	BPI	Bactericidal permeability increasing protein. (588 aa)
	LOC111769981	BPI fold-containing family A member 2-like. (249 aa)
	DEFB119	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (86 aa)
	DEFB118	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (120 aa)
	LOC111772122	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (369 aa)
	LOC111771935	Toll-like receptor 4. (843 aa)
	LTF	Lactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-\|- and -Arg-Arg-Ser-Arg-\|-, and of Z-Phe-Arg-\|-aminomethylcoumarin sites. (715 aa)
	LOC100064172	Uncharacterized protein. (155 aa)
	LOC111768487	Uncharacterized protein. (155 aa)
	CD14	CD14 molecule. (369 aa)
	BPIFA2	BPI fold containing family A member 2. (249 aa)
	LOC106782660	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (65 aa)
	NINJ2	Ninjurin 2. (188 aa)
	PSMA1	Proteasome subunit alpha type. (269 aa)
	DEFB114	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (67 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BPI	LOC111767791	ENSECAP00000029928	ENSECAP00000001239	Bactericidal permeability increasing protein.	CD14 molecule.	0.697
BPI	LOC111771935	ENSECAP00000029928	ENSECAP00000033420	Bactericidal permeability increasing protein.	Toll-like receptor 4.	0.428
BPI	LTF	ENSECAP00000029928	ENSECAP00000033689	Bactericidal permeability increasing protein.	Lactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-\|- and -Arg-Arg-Ser-Arg-\|-, and of Z-Phe-Arg-\|-aminomethylcoumarin sites.	0.671
BPI	LY96	ENSECAP00000029928	ENSECAP00000015094	Bactericidal permeability increasing protein.	Lymphocyte antigen 96.	0.471
BPI	TLR4	ENSECAP00000029928	ENSECAP00000008292	Bactericidal permeability increasing protein.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.437
CD14	LOC111767791	ENSECAP00000042386	ENSECAP00000001239	CD14 molecule.	CD14 molecule.	0.655
CD14	LOC111771935	ENSECAP00000042386	ENSECAP00000033420	CD14 molecule.	Toll-like receptor 4.	0.717
CD14	LOC111772122	ENSECAP00000042386	ENSECAP00000031530	CD14 molecule.	Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...]	0.543
CD14	LY96	ENSECAP00000042386	ENSECAP00000015094	CD14 molecule.	Lymphocyte antigen 96.	0.854
CD14	TLR4	ENSECAP00000042386	ENSECAP00000008292	CD14 molecule.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.723
CD14	TRIL	ENSECAP00000042386	ENSECAP00000026820	CD14 molecule.	TLR4 interactor with leucine rich repeats.	0.558
DEFB118	DEFB119	ENSECAP00000031369	ENSECAP00000030738	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	0.436
DEFB119	DEFB118	ENSECAP00000030738	ENSECAP00000031369	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	0.436
DEFB119	DEFB136	ENSECAP00000030738	ENSECAP00000001206	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	Uncharacterized protein.	0.611
DEFB119	F7CF08_HORSE	ENSECAP00000030738	ENSECAP00000000716	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	0.436
DEFB136	DEFB119	ENSECAP00000001206	ENSECAP00000030738	Uncharacterized protein.	Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.	0.611
ECATH-2	LTF	ENSECAP00000013589	ENSECAP00000033689	Myeloid cathelicidin 2.	Lactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-\|- and -Arg-Arg-Ser-Arg-\|-, and of Z-Phe-Arg-\|-aminomethylcoumarin sites.	0.400
F2	LTF	ENSECAP00000009701	ENSECAP00000033689	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Lactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-\|- and -Arg-Arg-Ser-Arg-\|-, and of Z-Phe-Arg-\|-aminomethylcoumarin sites.	0.409
F2	SELP	ENSECAP00000009701	ENSECAP00000009403	Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family.	Selectin P.	0.441
F6PQ40_HORSE	PSMA1	ENSECAP00000010484	ENSECAP00000054297	Proteasome subunit alpha type.	Proteasome subunit alpha type.	0.577