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TLR4 | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (843 aa) | ||||
LOC111771935 | Toll-like receptor 4. (843 aa) | ||||
SCARB1 | Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa) | ||||
LY96 | Lymphocyte antigen 96. (173 aa) |