(39 nodes) Heart looping network (Equus caballus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	LOC111775226	Mesoderm posterior bHLH transcription factor 1. (254 aa)
	SOX17	SRY-box transcription factor 17. (406 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
	NPHP3	Nephrocystin 3. (1505 aa)
	MIB1	Mindbomb E3 ubiquitin protein ligase 1. (1006 aa)
	LBX1	Ladybird homeobox 1. (263 aa)
	CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (294 aa)
	ARL13B	ADP ribosylation factor like GTPase 13B. (563 aa)
	AK1	Endoglin. (848 aa)
	APLNR	Apelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
	HAND1	Heart and neural crest derivatives expressed 1. (218 aa)
	SRF	Serum response factor. (512 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (217 aa)
	IFT57	Intraflagellar transport 57. (429 aa)
	FOXH1	Forkhead box H1. (360 aa)
	C2CD3	C2 domain containing 3 centriole elongation regulator. (2342 aa)
	ZIC3	Zic family member 3. (535 aa)
	DNAAF1	Dynein assembly factor 1, axonemal. (661 aa)
	CCDC40	Coiled-coil domain containing 40. (1140 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
	CCDC103	Coiled-coil domain containing 103. (420 aa)
	NODAL	Nodal growth differentiation factor. (348 aa)
	TBX3	T-box transcription factor 3. (745 aa)
	TBX20	T-box transcription factor 20. (449 aa)
	ASB2	Ankyrin repeat and SOCS box containing 2. (633 aa)
	SUFU	SUFU negative regulator of hedgehog signaling. (566 aa)
	AHI1	Uncharacterized protein. (1219 aa)
	TBX6	T-box transcription factor 6. (432 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
	NOTCH1	Notch receptor 1. (2581 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (958 aa)
	CLUAP1	Clusterin associated protein 1. (432 aa)
	MEF2C	Myocyte enhancer factor 2C. (483 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
	IFT52	Intraflagellar transport 52. (450 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (844 aa)
	NOTCH2	Notch receptor 2. (2471 aa)
	MICAL2	Microtubule associated monooxygenase, calponin and LIM domain containing 2. (1878 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AHI1	ARL13B	ENSECAP00000017407	ENSECAP00000033038	Uncharacterized protein.	ADP ribosylation factor like GTPase 13B.	0.664
AHI1	NPHP3	ENSECAP00000017407	ENSECAP00000029148	Uncharacterized protein.	Nephrocystin 3.	0.451
ARL13B	AHI1	ENSECAP00000033038	ENSECAP00000017407	ADP ribosylation factor like GTPase 13B.	Uncharacterized protein.	0.664
ARL13B	C2CD3	ENSECAP00000033038	ENSECAP00000010374	ADP ribosylation factor like GTPase 13B.	C2 domain containing 3 centriole elongation regulator.	0.775
ARL13B	IFT52	ENSECAP00000033038	ENSECAP00000051411	ADP ribosylation factor like GTPase 13B.	Intraflagellar transport 52.	0.693
ARL13B	IFT57	ENSECAP00000033038	ENSECAP00000009537	ADP ribosylation factor like GTPase 13B.	Intraflagellar transport 57.	0.718
ARL13B	IHH	ENSECAP00000033038	ENSECAP00000002787	ADP ribosylation factor like GTPase 13B.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.522
ARL13B	NPHP3	ENSECAP00000033038	ENSECAP00000029148	ADP ribosylation factor like GTPase 13B.	Nephrocystin 3.	0.724
ARL13B	PKD2	ENSECAP00000033038	ENSECAP00000021669	ADP ribosylation factor like GTPase 13B.	Polycystin 2, transient receptor potential cation channel.	0.835
ARL13B	SHH	ENSECAP00000033038	ENSECAP00000020524	ADP ribosylation factor like GTPase 13B.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.672
ARL13B	SMO	ENSECAP00000033038	ENSECAP00000028203	ADP ribosylation factor like GTPase 13B.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.910
ARL13B	SUFU	ENSECAP00000033038	ENSECAP00000017329	ADP ribosylation factor like GTPase 13B.	SUFU negative regulator of hedgehog signaling.	0.476
C2CD3	ARL13B	ENSECAP00000010374	ENSECAP00000033038	C2 domain containing 3 centriole elongation regulator.	ADP ribosylation factor like GTPase 13B.	0.775
CCDC103	CCDC40	ENSECAP00000014471	ENSECAP00000012008	Coiled-coil domain containing 103.	Coiled-coil domain containing 40.	0.832
CCDC103	DNAAF1	ENSECAP00000014471	ENSECAP00000011428	Coiled-coil domain containing 103.	Dynein assembly factor 1, axonemal.	0.846
CCDC40	CCDC103	ENSECAP00000012008	ENSECAP00000014471	Coiled-coil domain containing 40.	Coiled-coil domain containing 103.	0.832
CCDC40	DNAAF1	ENSECAP00000012008	ENSECAP00000011428	Coiled-coil domain containing 40.	Dynein assembly factor 1, axonemal.	0.771
CCDC40	NPHP3	ENSECAP00000012008	ENSECAP00000029148	Coiled-coil domain containing 40.	Nephrocystin 3.	0.476
CITED2	HIF1A	ENSECAP00000033030	ENSECAP00000048740	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2.	Hypoxia inducible factor 1 subunit alpha.	0.683
CITED2	SMAD3	ENSECAP00000033030	ENSECAP00000039707	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2.	Mothers against decapentaplegic homolog.	0.414