STRINGSTRING
GAS6 GAS6 PTPN2 PTPN2 ISG15 ISG15 SHARPIN SHARPIN LOC100071666 LOC100071666 ADAR ADAR F2RL1 F2RL1 ADIPOQ ADIPOQ CXCR4 CXCR4 CNOT7 CNOT7 SLIT3 SLIT3 SH2B3 SH2B3 SPATA2 SPATA2 LOC100054193 LOC100054193 CD300LF CD300LF ECM1 ECM1 TRIM32 TRIM32 SAMHD1 SAMHD1 MED1 MED1 PYCARD PYCARD NKIRAS1 NKIRAS1 RIPK1 RIPK1 OTOP1 OTOP1 GPS2 GPS2 YTHDF3 YTHDF3 EDN1 EDN1 AXL AXL PARP9 PARP9 TICAM2 TICAM2 CDC37 CDC37 IRAK2 IRAK2 METTL3 METTL3 TRAF2 TRAF2 UBE2K UBE2K PAFAH1B1 PAFAH1B1 TREM2 TREM2 MUL1 MUL1 HPX HPX CSF1 CSF1 RABGEF1 RABGEF1 NKIRAS2 NKIRAS2 NR1H4 NR1H4 IRF3 IRF3 TRIM56 TRIM56 DCST1 DCST1 BIRC7 BIRC7 IL36RN IL36RN IL7 IL7 TBK1 TBK1 FADD FADD VRK2 VRK2 TTLL12 TTLL12 PADI2 PADI2 STAT2 STAT2 YTHDF2 YTHDF2 PARP14 PARP14 RNF185 RNF185 SOCS1 SOCS1 ENSECAP00000023457 ENSECAP00000023457 PIAS4 PIAS4 XIAP XIAP LSM14A LSM14A IKBKE IKBKE GFI1 GFI1 STING1 STING1 NLRP6 NLRP6 RFFL RFFL ENSECAP00000029579 ENSECAP00000029579 OTULIN OTULIN OTUD4 OTUD4 RIPK2 RIPK2 SIGIRR SIGIRR HIPK1 HIPK1 TRIM44 TRIM44 SYK SYK PTPRC PTPRC CACTIN CACTIN CD74 CD74 CAV1 CAV1 PELI3 PELI3 NOL3 NOL3 SLIT2 SLIT2 SPHK1 SPHK1 ZBP1 ZBP1 PALM3 PALM3 IRAK1 IRAK1 NLRC5 NLRC5 MAVS MAVS IL1R2 IL1R2 STAP1 STAP1 HIF1A HIF1A TREX1 TREX1 TRAIP TRAIP IL1RN IL1RN C1QTNF4 C1QTNF4 CYLD CYLD TNFRSF1A TNFRSF1A PRKN PRKN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GAS6Growth arrest specific 6. (646 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (388 aa)
ISG15ISG15 ubiquitin like modifier. (164 aa)
SHARPINSHANK associated RH domain interactor. (384 aa)
LOC100071666RanBP2-type domain-containing protein. (413 aa)
ADARAdenosine deaminase RNA specific. (1171 aa)
F2RL1F2R like trypsin receptor 1. (397 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (301 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
CNOT7CCR4-NOT transcription complex subunit 7. (285 aa)
SLIT3Slit guidance ligand 3. (1521 aa)
SH2B3SH2B adaptor protein 3. (561 aa)
SPATA2Spermatogenesis associated 2. (520 aa)
LOC100054193Histone H2B; Belongs to the histone H2B family. (126 aa)
CD300LFIGv domain-containing protein. (300 aa)
ECM1Extracellular matrix protein 1. (543 aa)
TRIM32Tripartite motif containing 32. (653 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (670 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
PYCARDPYD and CARD domain containing. (195 aa)
NKIRAS1NFKB inhibitor interacting Ras like 1. (192 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
OTOP1Otopetrin 1. (592 aa)
GPS2G protein pathway suppressor 2. (327 aa)
YTHDF3YTH N6-methyladenosine RNA binding protein 3. (588 aa)
EDN1Endothelin 1. (202 aa)
AXLAXL receptor tyrosine kinase. (887 aa)
PARP9Poly(ADP-ribose) polymerase family member 9. (860 aa)
TICAM2TIR domain-containing protein. (238 aa)
CDC37Cell division cycle 37. (379 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (621 aa)
METTL3Methyltransferase like 3; Belongs to the MT-A70-like family. (580 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
UBE2KUbiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (200 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (413 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (298 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (422 aa)
HPXHemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (462 aa)
CSF1Colony stimulating factor 1. (630 aa)
RABGEF1RAB guanine nucleotide exchange factor 1. (492 aa)
NKIRAS2NFKB inhibitor interacting Ras like 2. (191 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
IRF3Interferon regulatory factor 3. (426 aa)
TRIM56Tripartite motif containing 56. (755 aa)
DCST1DC-STAMP domain containing 1. (706 aa)
BIRC7Baculoviral IAP repeat containing 7. (282 aa)
IL36RNInterleukin-1. (155 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (176 aa)
TBK1TANK binding kinase 1. (729 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (212 aa)
VRK2VRK serine/threonine kinase 2. (507 aa)
TTLL12Tubulin tyrosine ligase like 12. (806 aa)
PADI2Peptidyl arginine deiminase 2. (665 aa)
STAT2Signal transducer and activator of transcription. (847 aa)
YTHDF2YTH N6-methyladenosine RNA binding protein 2. (580 aa)
PARP14Poly [ADP-ribose] polymerase. (1798 aa)
RNF185Ring finger protein 185. (192 aa)
SOCS1Suppressor of cytokine signaling 1. (222 aa)
ENSECAP00000023457Uncharacterized protein. (189 aa)
PIAS4Protein inhibitor of activated STAT 4. (536 aa)
XIAPX-linked inhibitor of apoptosis. (494 aa)
LSM14ALSM14A mRNA processing body assembly factor. (507 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (822 aa)
GFI1Growth factor independent 1 transcriptional repressor. (422 aa)
STING1Transmembrane protein 173. (405 aa)
NLRP6NLR family pyrin domain containing 6. (892 aa)
RFFLRing finger and FYVE like domain containing E3 ubiquitin protein ligase. (398 aa)
ENSECAP00000029579SH2 domain-containing protein. (203 aa)
OTULINOTU deubiquitinase with linear linkage specificity. (350 aa)
OTUD4OTU deubiquitinase 4. (1145 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (569 aa)
SIGIRRSingle Ig and TIR domain containing. (509 aa)
HIPK1Homeodomain interacting protein kinase 1. (1245 aa)
TRIM44Tripartite motif containing 44. (378 aa)
SYKTyrosine-protein kinase. (716 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1399 aa)
CACTINCactin, spliceosome C complex subunit. (753 aa)
CD74CD74 molecule. (272 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
PELI3Pellino E3 ubiquitin protein ligase family member 3. (521 aa)
NOL3CARD domain-containing protein. (214 aa)
SLIT2Slit guidance ligand 2. (1543 aa)
SPHK1Sphingosine kinase 1. (459 aa)
ZBP1Z-DNA binding protein 1. (436 aa)
PALM3Paralemmin 3. (640 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (805 aa)
NLRC5NLR family CARD domain containing 5. (1868 aa)
MAVSMitochondrial antiviral signaling protein. (597 aa)
IL1R2Interleukin 1 receptor type 2. (488 aa)
STAP1Signal transducing adaptor family member 1. (297 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (844 aa)
TREX1Three prime repair exonuclease 1. (314 aa)
TRAIPTRAF interacting protein. (505 aa)
IL1RNInterleukin-1 receptor antagonist protein; Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity; Belongs to the IL-1 family. (177 aa)
C1QTNF4C1q domain-containing protein. (98 aa)
CYLDCYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (956 aa)
TNFRSF1ATNF receptor superfamily member 1A. (475 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (466 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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