STRINGSTRING
TYROBP TYROBP IL18RAP IL18RAP TRAF3IP2 TRAF3IP2 IFI35 IFI35 TNF TNF MYD88 MYD88 F2RL1 F2RL1 PRKCE PRKCE CX3CR1 CX3CR1 C5AR1 C5AR1 MILR1 MILR1 ADAM9 ADAM9 PTGDR PTGDR ADAM10 ADAM10 IL4 IL4 DNASE1 DNASE1 SNAP23 SNAP23 FCER1G FCER1G CSF2 CSF2 IL13 IL13 PYCARD PYCARD TLR4 TLR4 RASGRP1 RASGRP1 BATF3 BATF3 TGFB1 TGFB1 ENPP3 ENPP3 KIT KIT SLAMF1 SLAMF1 CPLX2 CPLX2 TREM2 TREM2 HAVCR2 HAVCR2 CXCL8 CXCL8 BATF BATF ANXA1 ANXA1 PLA2G10 PLA2G10 CAMK4 CAMK4 L3HYPDH L3HYPDH RABGEF1 RABGEF1 ANXA3 ANXA3 DCSTAMP DCSTAMP ITGB8 ITGB8 GRP GRP RELB RELB AGER AGER TRAF6 TRAF6 JMJD6 JMJD6 STARD7 STARD7 STXBP3 STXBP3 LCP2 LCP2 APP APP S100A13 S100A13 JUN JUN DNASE1L2 DNASE1L2 SUCNR1 SUCNR1 CRTC3 CRTC3 PLA2G3 PLA2G3 DOCK2 DOCK2 STK39 STK39 DNASE1L3 DNASE1L3 DYSF DYSF CLNK CLNK ENSECAP00000024650 ENSECAP00000024650 IL15 IL15 IRF4 IRF4 NDRG1 NDRG1 CD99 CD99 KMT2E KMT2E CHGA CHGA IFNG IFNG TMEM106A TMEM106A LOC100051526 LOC100051526 PLCG2 PLCG2 FOXP1 FOXP1 ENSECAP00000033220 ENSECAP00000033220 LOC111771935 LOC111771935 VAMP7 VAMP7 RHOH RHOH LOC100146250 LOC100146250 SLC11A1 SLC11A1 ADGRF5 ADGRF5 SYK SYK LTBR LTBR BCR BCR NMI NMI IL18 IL18 AZU1 AZU1 SBNO2 SBNO2 BATF2 BATF2 LOC100630393 LOC100630393 RAB44 RAB44 LOC100063866 LOC100063866 NOTCH2 NOTCH2 CCL3 CCL3 TREX1 TREX1 KARS1 KARS1 VAMP2 VAMP2 CHGA-2 CHGA-2 PTGDS PTGDS WNK4 WNK4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TYROBPTYRO protein tyrosine kinase binding protein. (144 aa)
IL18RAPInterleukin 18 receptor accessory protein. (600 aa)
TRAF3IP2TRAF3 interacting protein 2. (578 aa)
IFI35Interferon induced protein 35. (280 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
F2RL1F2R like trypsin receptor 1. (397 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (386 aa)
C5AR1Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (374 aa)
MILR1Mast cell immunoglobulin like receptor 1. (348 aa)
ADAM9ADAM metallopeptidase domain 9. (819 aa)
PTGDRProstaglandin D2 receptor. (293 aa)
ADAM10ADAM metallopeptidase domain 10. (748 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (139 aa)
DNASE1Deoxyribonuclease-1; Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (By similarity). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA. Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization (By similarity). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation. Degradation of intra [...] (282 aa)
SNAP23Synaptosomal-associated protein; Belongs to the SNAP-25 family. (211 aa)
FCER1GFc fragment of IgE receptor Ig. (86 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (152 aa)
IL13Interleukin-13. (133 aa)
PYCARDPYD and CARD domain containing. (195 aa)
TLR4Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (843 aa)
RASGRP1RAS guanyl releasing protein 1. (797 aa)
BATF3Basic leucine zipper ATF-like transcription factor 3. (253 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
ENPP3Ectonucleotide pyrophosphatase/phosphodiesterase 3. (918 aa)
KITKIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1084 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (338 aa)
CPLX2Complexin 2. (134 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (298 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (280 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity). (101 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (346 aa)
PLA2G10Phospholipase A(2). (160 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
L3HYPDHTrans-L-3-hydroxyproline dehydratase. (354 aa)
RABGEF1RAB guanine nucleotide exchange factor 1. (492 aa)
ANXA3Annexin. (323 aa)
DCSTAMPDendrocyte expressed seven transmembrane protein. (470 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (767 aa)
GRPGastrin releasing peptide. (138 aa)
RELBRELB proto-oncogene, NF-kB subunit. (709 aa)
AGERAdvanced glycosylation end-product specific receptor. (403 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (564 aa)
JMJD6Jumonji domain containing 6, arginine demethylase and lysine hydroxylase. (414 aa)
STARD7StAR related lipid transfer domain containing 7. (375 aa)
STXBP3Pre-mRNA processing factor 38B; Belongs to the STXBP/unc-18/SEC1 family. (1126 aa)
LCP2Lymphocyte cytosolic protein 2. (533 aa)
APPAmyloid beta precursor protein. (811 aa)
S100A13S100 calcium binding protein A13; Belongs to the S-100 family. (98 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (340 aa)
DNASE1L2Deoxyribonuclease; Belongs to the DNase I family. (278 aa)
SUCNR1Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family. (350 aa)
CRTC3CREB regulated transcription coactivator 3. (619 aa)
PLA2G3Phospholipase A2 group III. (513 aa)
DOCK2Dedicator of cytokinesis 2; Belongs to the DOCK family. (1828 aa)
STK39Serine/threonine kinase 39. (556 aa)
DNASE1L3Deoxyribonuclease; Belongs to the DNase I family. (311 aa)
DYSFDysferlin. (2121 aa)
CLNKCytokine dependent hematopoietic cell linker. (429 aa)
ENSECAP00000024650Uncharacterized protein. (88 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (432 aa)
IRF4Interferon regulatory factor 4. (606 aa)
NDRG1N-myc downstream regulated 1. (384 aa)
CD99CD99 molecule (Xg blood group). (209 aa)
KMT2ELysine methyltransferase 2E. (1857 aa)
CHGAp-Glu serpinin precursor; [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. (458 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
TMEM106ATransmembrane protein 106A. (261 aa)
LOC100051526Uncharacterized protein. (285 aa)
PLCG2Phosphoinositide phospholipase C. (1331 aa)
FOXP1Forkhead box P1. (691 aa)
ENSECAP00000033220AIG1-type G domain-containing protein. (267 aa)
LOC111771935Toll-like receptor 4. (843 aa)
VAMP7Vesicle associated membrane protein 7; Belongs to the synaptobrevin family. (276 aa)
RHOHRas homolog family member H. (191 aa)
LOC100146250AIG1-type G domain-containing protein. (315 aa)
SLC11A1Solute carrier family 11 member 1. (648 aa)
ADGRF5Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. (1386 aa)
SYKTyrosine-protein kinase. (716 aa)
LTBRLymphotoxin beta receptor. (434 aa)
BCRBCR activator of RhoGEF and GTPase. (1325 aa)
NMIN-myc and STAT interactor. (309 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
AZU1Azurocidin 1. (251 aa)
SBNO2Strawberry notch homolog 2. (1370 aa)
BATF2Basic leucine zipper ATF-like transcription factor 2. (272 aa)
LOC100630393AIG1-type G domain-containing protein. (315 aa)
RAB44RAB44, member RAS oncogene family. (1012 aa)
LOC100063866AIG1-type G domain-containing protein. (413 aa)
NOTCH2Notch receptor 2. (2471 aa)
CCL3SCY domain-containing protein. (226 aa)
TREX1Three prime repair exonuclease 1. (314 aa)
KARS1Lysine--tRNA ligase. (625 aa)
VAMP2V-SNARE coiled-coil homology domain-containing protein. (118 aa)
CHGA-2Chromogranin A. (458 aa)
PTGDSProstaglandin-H2 D-isomerase; Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possib [...] (200 aa)
WNK4WNK lysine deficient protein kinase 4. (1246 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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