STRINGSTRING
TLR6 TLR6 MYD88 MYD88 TLR8 TLR8 TNIP1 TNIP1 IRAK2 IRAK2 TLR9 TLR9 TLR2 TLR2 TLR10 TLR10 IRAK3 IRAK3 TLR7 TLR7 TLR1 TLR1 ENSECAP00000036381 ENSECAP00000036381 TLR5 TLR5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TLR6Toll-like receptor. (859 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
TLR8Toll-like receptor 8; Belongs to the Toll-like receptor family. (1038 aa)
TNIP1TNFAIP3 interacting protein 1. (723 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (621 aa)
TLR9Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1031 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
TLR10Toll like receptor 10; Belongs to the Toll-like receptor family. (811 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (614 aa)
TLR7Toll like receptor 7; Belongs to the Toll-like receptor family. (1054 aa)
TLR1Toll-like receptor. (756 aa)
ENSECAP00000036381TIR domain-containing protein; Belongs to the Toll-like receptor family. (772 aa)
TLR5Toll like receptor 5; Belongs to the Toll-like receptor family. (867 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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