STRINGSTRING
SMAD1 SMAD1 EXT1 EXT1 AXIN1 AXIN1 BMPR2 BMPR2 ITGA2 ITGA2 EXOC4 EXOC4 WNT3A WNT3A COL6A1 COL6A1 APELA APELA SMAD4 SMAD4 MESP2 MESP2 PLPP3 PLPP3 TENM4 TENM4 NPHP3 NPHP3 LOC100071364 LOC100071364 ATOH8 ATOH8 PRKACA PRKACA NF2 NF2 TP53 TP53 SGCA SGCA POGLUT1 POGLUT1 ITGB5 ITGB5 COL12A1 COL12A1 NODAL NODAL VTN VTN HNF1B HNF1B UGDH UGDH CER1 CER1 RNF2 RNF2 ITGA8 ITGA8 DUSP5 DUSP5 ZIC3 ZIC3 HOXA11 HOXA11 LDB1 LDB1 NANOG NANOG LOC100071373 LOC100071373 CD63 CD63 CTR9 CTR9 ITGB4 ITGB4 ITGA4 ITGA4 TLX2 TLX2 ETV2 ETV2 MMP15 MMP15 PRKAR1A PRKAR1A LHX1 LHX1 MSGN1 MSGN1 DVL2 DVL2 APLNR APLNR HAND1 HAND1 RIC8A RIC8A LRP5 LRP5 LEO1 LEO1 MIXL1 MIXL1 FRS2 FRS2 LEF1 LEF1 APLN APLN SOX17 SOX17 AMOT AMOT LOC111775202 LOC111775202 LOC111775226 LOC111775226 HMGA2 HMGA2 SMAD3 SMAD3 KDM6A KDM6A EYA1 EYA1 PAF1 PAF1 ITGAV ITGAV COL4A2 COL4A2 RP1L1 RP1L1 GATA6 GATA6 RTF1 RTF1 SETD2 SETD2 ITGB1 ITGB1 ITGA5 ITGA5 DUSP2 DUSP2 ZBTB17 ZBTB17 CUL3 CUL3 TBX19 TBX19 EXT2 EXT2 POFUT2 POFUT2 FN1 FN1 TAF10 TAF10 TBXT TBXT LAMB3 LAMB3 MMP14 MMP14 EPHA2 EPHA2 SRF SRF LAMB1 LAMB1 SNAI1 SNAI1 TASOR TASOR KDM6B KDM6B DUSP1 DUSP1 ARMC5 ARMC5 GRB2 GRB2 DUSP4 DUSP4 SFRP2 SFRP2 BMP4 BMP4 NR0B1 NR0B1 TWSG1 TWSG1 TAL1 TAL1 LMBRD1 LMBRD1 ITGB3 ITGB3 GPI GPI COL8A1 COL8A1 MEGF8 MEGF8 ARFRP1 ARFRP1 HNF1A HNF1A FOXF1 FOXF1 BMPR1A BMPR1A DVL1 DVL1 EOMES EOMES SFRP1 SFRP1 MMP1 MMP1 CRB2 CRB2 WNT3 WNT3 WNT11 WNT11 TBX6 TBX6 INHBA INHBA RACK1 RACK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMAD1Mothers against decapentaplegic homolog. (465 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
AXIN1Axin 1. (939 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1301 aa)
EXOC4Exocyst complex component 4. (975 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
COL6A1Collagen type VI alpha 1 chain. (1027 aa)
APELAUncharacterized protein. (53 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
MESP2BHLH domain-containing protein. (371 aa)
PLPP3Phospholipid phosphatase 3. (312 aa)
TENM4Teneurin transmembrane protein 4. (2866 aa)
NPHP3Nephrocystin 3. (1505 aa)
LOC100071364Uncharacterized protein. (243 aa)
ATOH8Atonal bHLH transcription factor 8. (388 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (359 aa)
NF2Neurofibromin 2. (637 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (381 aa)
SGCAIntegrin subunit alpha 3; Belongs to the integrin alpha chain family. (1075 aa)
POGLUT1Protein O-glucosyltransferase 1. (392 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (837 aa)
COL12A1Collagen type XII alpha 1 chain. (3120 aa)
NODALNodal growth differentiation factor. (348 aa)
VTNVitronectin. (478 aa)
HNF1BHNF1 homeobox B. (558 aa)
UGDHUDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (513 aa)
CER1Cerberus 1, DAN family BMP antagonist. (273 aa)
RNF2Ring finger protein 2. (351 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (1062 aa)
DUSP5Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (384 aa)
ZIC3Zic family member 3. (535 aa)
HOXA11Homeobox A11. (316 aa)
LDB1LIM domain binding 1. (411 aa)
NANOGHomeobox domain-containing protein. (310 aa)
LOC100071373Uncharacterized protein. (245 aa)
CD63Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1224 aa)
CTR9CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa)
ITGB4Integrin beta. (1805 aa)
ITGA4Integrin subunit alpha 4; Belongs to the integrin alpha chain family. (1033 aa)
TLX2T cell leukemia homeobox 2. (284 aa)
ETV2ETS variant 2. (248 aa)
MMP15Matrix metallopeptidase 15. (912 aa)
PRKAR1AcAMP-dependent protein kinase type I-alph regulatory subunit-like protein. (378 aa)
LHX1LIM homeobox 1. (405 aa)
MSGN1Mesogenin 1. (193 aa)
DVL2Dishevelled segment polarity protein 2. (737 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
HAND1Heart and neural crest derivatives expressed 1. (218 aa)
RIC8ARIC8 guanine nucleotide exchange factor A. (530 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
LEO1LEO1 homolog, Paf1/RNA polymerase II complex component. (691 aa)
MIXL1Mix paired-like homeobox. (231 aa)
FRS2Fibroblast growth factor receptor substrate 2. (515 aa)
LEF1Lymphoid enhancer binding factor 1. (413 aa)
APLNUncharacterized protein. (186 aa)
SOX17SRY-box transcription factor 17. (406 aa)
AMOTAngiomotin. (1089 aa)
LOC111775202BHLH domain-containing protein. (256 aa)
LOC111775226Mesoderm posterior bHLH transcription factor 1. (254 aa)
HMGA2Uncharacterized protein. (156 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
KDM6ALysine demethylase 6A. (1453 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa)
PAF1PAF1 homolog, Paf1/RNA polymerase II complex component. (582 aa)
ITGAVFamily with sequence similarity 171 member B; Belongs to the integrin alpha chain family. (1787 aa)
COL4A2Collagen type IV alpha 2 chain. (1867 aa)
RP1L1Uncharacterized protein. (387 aa)
GATA6GATA binding protein 6. (598 aa)
RTF1RTF1 homolog, Paf1/RNA polymerase II complex component. (730 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2563 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (808 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1248 aa)
DUSP2Dual specificity phosphatase 2. (326 aa)
ZBTB17Zinc finger and BTB domain containing 17. (834 aa)
CUL3Cullin 3; Belongs to the cullin family. (772 aa)
TBX19T-box transcription factor 19. (445 aa)
EXT2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (750 aa)
POFUT2Protein O-fucosyltransferase 2. (573 aa)
FN1Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). (2477 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa)
TBXTT-box transcription factor T. (435 aa)
LAMB3Laminin subunit beta 3. (1185 aa)
MMP14Matrix metallopeptidase 14. (581 aa)
EPHA2EPH receptor A2. (975 aa)
SRFSerum response factor. (512 aa)
LAMB1Laminin subunit beta 1. (1834 aa)
SNAI1Snail family transcriptional repressor 1. (265 aa)
TASORTranscription activation suppressor. (1613 aa)
KDM6BLysine demethylase 6B. (1636 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (419 aa)
ARMC5Armadillo repeat containing 5. (940 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (411 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
NR0B1Nuclear receptor subfamily 0 group B member 1. (471 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (331 aa)
LMBRD1LMBR1 domain containing 1. (541 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (573 aa)
COL8A1Collagen type VIII alpha 1 chain. (735 aa)
MEGF8Multiple EGF like domains 8. (2789 aa)
ARFRP1ADP ribosylation factor related protein 1. (201 aa)
HNF1AHNF1 homeobox A. (631 aa)
FOXF1Forkhead box F1. (431 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
DVL1Dishevelled segment polarity protein 1. (700 aa)
EOMESEomesodermin. (702 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
MMP1Interstitial collagenase. (520 aa)
CRB2Crumbs cell polarity complex component 2. (1286 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (475 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
TBX6T-box transcription factor 6. (432 aa)
INHBAInhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. (426 aa)
RACK1WD_REPEATS_REGION domain-containing protein. (317 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.