STRINGSTRING
TGFB1 TGFB1 NFIB NFIB PTPN11 PTPN11 DLX1 DLX1 POU3F1 POU3F1 HES1 HES1 CNTN1 CNTN1 SOX4 SOX4 TTC21B TTC21B MED12 MED12 S100A9 S100A9 METRN METRN HES5 HES5 PRDM8 PRDM8 ADGRG6 ADGRG6 SH3TC1 SH3TC1 MMP24 MMP24 WDR92 WDR92 SMO SMO NDRG1 NDRG1 PLPP3 PLPP3 TENM4 TENM4 ILK ILK LOC100061598 LOC100061598 ERCC2 ERCC2 SIRT2 SIRT2 IFNG IFNG NTRK2 NTRK2 EIF2B3 EIF2B3 SH3TC2 SH3TC2 ABL1 ABL1 EIF2B2 EIF2B2 DNER DNER TRPC4 TRPC4 AKT1 AKT1 OLIG1 OLIG1 EMX1 EMX1 STAT3 STAT3 METRNL METRNL NKX2-1 NKX2-1 LEF1 LEF1 ENSECAP00000039029 ENSECAP00000039029 NCSTN NCSTN SOD1 SOD1 NKX6-2 NKX6-2 PRX PRX LOC100061631 LOC100061631 ARHGEF10 ARHGEF10 GLI3 GLI3 OLIG2 OLIG2 ASCL1 ASCL1 PLP1 PLP1 SOX8 SOX8 MAPK1 MAPK1 CRB1 CRB1 MTOR MTOR GAP43 GAP43 ZNF488 ZNF488 LOC100051785 LOC100051785 NCMAP NCMAP ERBB3 ERBB3 CDK5 CDK5 SOX10 SOX10 CUL4B CUL4B VAX1 VAX1 NOTCH1 NOTCH1 GBA GBA LAMB2 LAMB2 B4GALT5 B4GALT5 APP APP SOX9 SOX9 MYRF MYRF NKX6-1 NKX6-1 GPR157 GPR157 ASPA ASPA METTL14 METTL14 RELN RELN EIF2B1 EIF2B1 PAX6 PAX6 LGI4 LGI4 BMP2 BMP2 AGER AGER MXRA8 MXRA8 FA2H FA2H SUZ12 SUZ12 AKT3 AKT3 TPPP TPPP KRAS KRAS GPR37L1 GPR37L1 NR2E1 NR2E1 EIF2B5 EIF2B5 NKX2-2 NKX2-2 CNTN2 CNTN2 TAL1 TAL1 B4GALT6 B4GALT6 VTN VTN TREM2 TREM2 MT3 MT3 MAPK3 MAPK3 FGF2 FGF2 DLL1 DLL1 FGF10 FGF10 GCM1 GCM1 PHOX2B PHOX2B SOX13 SOX13 S100B S100B WASF3 WASF3 DLX2 DLX2 NRROS NRROS MPP5 MPP5 LAMC3 LAMC3 PICK1 PICK1 C5AR1 C5AR1 PHGDH PHGDH NAB2 NAB2 AKT2 AKT2 NF1 NF1 DUSP10 DUSP10 MYOC MYOC GFAP GFAP S100A8 S100A8 EGR2 EGR2 TSPAN2 TSPAN2 ITGB4 ITGB4 MAG MAG PTPRZ1 PTPRZ1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (571 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (606 aa)
DLX1Distal-less homeobox 1. (255 aa)
POU3F1POU domain protein. (451 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
CNTN1Contactin 1. (1032 aa)
SOX4SRY-box transcription factor 4. (496 aa)
TTC21BTetratricopeptide repeat domain 21B. (1323 aa)
MED12Mediator complex subunit 12. (2099 aa)
S100A9EF-hand domain-containing protein; Belongs to the S-100 family. (153 aa)
METRNUncharacterized protein. (532 aa)
HES5Hes family bHLH transcription factor 5. (164 aa)
PRDM8PR/SET domain 8. (689 aa)
ADGRG6Adhesion G protein-coupled receptor G6; Belongs to the G-protein coupled receptor 2 family. (1257 aa)
SH3TC1SH3 domain and tetratricopeptide repeats 1. (1400 aa)
MMP24Matrix metallopeptidase 24. (591 aa)
WDR92Protein phosphatase 3 regulatory subunit B, alpha. (496 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
NDRG1N-myc downstream regulated 1. (384 aa)
PLPP3Phospholipid phosphatase 3. (312 aa)
TENM4Teneurin transmembrane protein 4. (2866 aa)
ILKIntegrin linked kinase. (452 aa)
LOC100061598EF-hand domain-containing protein; Belongs to the S-100 family. (162 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (769 aa)
SIRT2Sirtuin 2. (462 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
EIF2B3Eukaryotic translation initiation factor 2B subunit gamma. (470 aa)
SH3TC2SH3 domain and tetratricopeptide repeats 2. (1292 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
EIF2B2Eukaryotic translation initiation factor 2B subunit beta; Belongs to the eIF-2B alpha/beta/delta subunits family. (361 aa)
DNERDelta/notch like EGF repeat containing. (734 aa)
TRPC4Transient receptor potential cation channel subfamily C member 4; Belongs to the transient receptor (TC 1.A.4) family. (982 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
OLIG1Oligodendrocyte transcription factor 1. (263 aa)
EMX1Empty spiracles homeobox 1. (328 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
METRNLMeteorin like, glial cell differentiation regulator. (324 aa)
NKX2-1NK2 homeobox 1. (610 aa)
LEF1Lymphoid enhancer binding factor 1. (413 aa)
ENSECAP00000039029Uncharacterized protein. (188 aa)
NCSTNNicastrin. (709 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (171 aa)
NKX6-2NK6 homeobox 2. (277 aa)
PRXPeriaxin. (1503 aa)
LOC100061631EF-hand domain-containing protein; Belongs to the S-100 family. (160 aa)
ARHGEF10Rho guanine nucleotide exchange factor 10. (1408 aa)
GLI3GLI family zinc finger 3. (1581 aa)
OLIG2Oligodendrocyte transcription factor 2. (323 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (325 aa)
PLP1Proteolipid protein 1. (396 aa)
SOX8SRY-box 8. (460 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (594 aa)
CRB1Crumbs cell polarity complex component 1. (1377 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2573 aa)
GAP43Growth associated protein 43. (268 aa)
ZNF488Zinc finger protein 488. (234 aa)
LOC100051785Uncharacterized protein. (188 aa)
NCMAPNon-compact myelin associated protein. (102 aa)
ERBB3Erb-b2 receptor tyrosine kinase 3. (1339 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
SOX10SRY-box transcription factor 10. (546 aa)
CUL4BCullin 4B; Belongs to the cullin family. (920 aa)
VAX1Ventral anterior homeobox 1. (332 aa)
NOTCH1Notch receptor 1. (2581 aa)
GBAGlucosylceramidase. (536 aa)
LAMB2Laminin subunit beta 2. (1801 aa)
B4GALT5Beta-1,4-galactosyltransferase 5. (388 aa)
APPAmyloid beta precursor protein. (811 aa)
SOX9SRY-box 9. (509 aa)
MYRFMyelin regulatory factor. (1186 aa)
NKX6-1NK6 homeobox 1. (366 aa)
GPR157G protein-coupled receptor 157. (441 aa)
ASPAAspartoacylase. (324 aa)
METTL14Methyltransferase like 14; Belongs to the MT-A70-like family. (456 aa)
RELNReelin. (3460 aa)
EIF2B1Eukaryotic translation initiation factor 2B subunit alpha; Belongs to the eIF-2B alpha/beta/delta subunits family. (305 aa)
PAX6Paired box 6. (436 aa)
LGI4Leucine rich repeat LGI family member 4. (537 aa)
BMP2Bone morphogenetic protein 2. (397 aa)
AGERAdvanced glycosylation end-product specific receptor. (403 aa)
MXRA8Matrix remodeling associated 8. (444 aa)
FA2HFatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (372 aa)
SUZ12SUZ12 polycomb repressive complex 2 subunit. (739 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
TPPPTubulin polymerization promoting protein. (544 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
GPR37L1G protein-coupled receptor 37 like 1. (482 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
EIF2B5Eukaryotic translation initiation factor 2B subunit epsilon. (786 aa)
NKX2-2NK2 homeobox 2. (273 aa)
CNTN2Contactin 2. (1040 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (331 aa)
B4GALT6Beta-1,4-galactosyltransferase 6. (382 aa)
VTNVitronectin. (478 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (298 aa)
MT3Metallothionein-3; Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium; Belongs to the metallothionein superfamily. Type 1 family. (68 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
GCM1Glial cells missing transcription factor 1. (435 aa)
PHOX2BPaired like homeobox 2B. (310 aa)
SOX13SRY-box 13. (615 aa)
S100BProtein S100; Belongs to the S-100 family. (93 aa)
WASF3WASP family member 3. (502 aa)
DLX2Distal-less homeobox 2. (327 aa)
NRROSNegative regulator of reactive oxygen species. (692 aa)
MPP5Membrane palmitoylated protein 5; Belongs to the MAGUK family. (675 aa)
LAMC3Laminin subunit gamma 3. (1578 aa)
PICK1Protein interacting with PRKCA 1. (417 aa)
C5AR1Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (374 aa)
PHGDHD-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (533 aa)
NAB2NGFI-A binding protein 2. (716 aa)
AKT2Non-specific serine/threonine protein kinase. (528 aa)
NF1Neurofibromin 1. (3024 aa)
DUSP10Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
MYOCMyocilin. (490 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (559 aa)
S100A8Protein S100; Belongs to the S-100 family. (89 aa)
EGR2Early growth response 2. (486 aa)
TSPAN2Tetraspanin. (309 aa)
ITGB4Integrin beta. (1805 aa)
MAGMyelin associated glycoprotein. (626 aa)
PTPRZ1Protein tyrosine phosphatase receptor type Z1. (2327 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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