STRINGSTRING
SETX SETX ADAM9 ADAM9 ATP2B4 ATP2B4 DDI1 DDI1 FIBIN FIBIN SYT5 SYT5 TIMELESS TIMELESS SCN5A SCN5A JUNB JUNB SLC30A1 SLC30A1 FOXO1 FOXO1 F6W654_HORSE F6W654_HORSE HSF1 HSF1 LOC111767444 LOC111767444 HMOX1 HMOX1 DDI2 DDI2 S100A16 S100A16 PTCH1 PTCH1 LOC100630858 LOC100630858 TRPA1 TRPA1 SMPD3 SMPD3 P2RX4 P2RX4 AQP2 AQP2 MNAT1 MNAT1 PKD2L1 PKD2L1 IL1A IL1A CDKN1B CDKN1B RASGRP2 RASGRP2 STIM1 STIM1 CACNA1H CACNA1H LOC102149958 LOC102149958 CCS CCS GLRA1 GLRA1 LOC100072585 LOC100072585 PRKAA1 PRKAA1 ACER1 ACER1 PAM PAM HVCN1 HVCN1 LOC100064042 LOC100064042 GSS GSS EZH2 EZH2 NET1 NET1 PEF1 PEF1 GUCY1B1 GUCY1B1 DAXX DAXX PDCD6 PDCD6 FGF23 FGF23 CPNE7 CPNE7 BAP1 BAP1 NQO1 NQO1 KDR KDR MIEN1 MIEN1 ZNF277 ZNF277 BMP6 BMP6 ANXA11 ANXA11 SIGMAR1 SIGMAR1 GSK3A GSK3A SLC1A3 SLC1A3 SYT11 SYT11 CYP1B1 CYP1B1 CPNE2 CPNE2 CPNE4 CPNE4 TIGAR TIGAR FXN FXN ITPKA ITPKA OSER1 OSER1 SLC41A1 SLC41A1 CRHBP CRHBP HAAO HAAO PDCD10 PDCD10 STK25 STK25 RAD51 RAD51 CARF CARF SYT4 SYT4 BNIP3 BNIP3 SLC30A8 SLC30A8 MTF1 MTF1 SLC34A1 SLC34A1 PRDX3 PRDX3 PARK7 PARK7 SYT10 SYT10 IL6 IL6 ABCB6 ABCB6 ATF1 ATF1 ANKZF1 ANKZF1 ANXA1 ANXA1 CUTA CUTA SYT3 SYT3 ACO1 ACO1 PIK3CA PIK3CA SLC12A3 SLC12A3 GLRX2 GLRX2 NCF1 NCF1 SLC38A2 SLC38A2 LOC100630794 LOC100630794 MT3 MT3 PLEKHA1 PLEKHA1 CER1 CER1 MAPK3 MAPK3 ERCC6 ERCC6 FOS FOS RELA RELA RPS3 RPS3 CREB1 CREB1 GLRA2 GLRA2 MT4 MT4 KCNMB4 KCNMB4 STK26 STK26 MAPK7 MAPK7 HOMER1 HOMER1 ADPRHL2 ADPRHL2 ENPP1 ENPP1 TXN TXN ADD1 ADD1 TRAF2 TRAF2 LOC111770212 LOC111770212 RNF112 RNF112 PRKAA2 PRKAA2 SYT1 SYT1 SMPD1 SMPD1 KCNMA1 KCNMA1 F6SJC9_HORSE F6SJC9_HORSE CRYAB CRYAB SLC30A10 SLC30A10 SRC SRC SOD2 SOD2 ALG2 ALG2 SLC30A3 SLC30A3 MEF2A MEF2A EDN1 EDN1 PRDX2 PRDX2 BLM BLM NFATC4 NFATC4 SYT2 SYT2 LRRK2 LRRK2 TCIRG1 TCIRG1 LGMN LGMN SLC30A2 SLC30A2 FGB FGB P2RX7 P2RX7 RIPK1 RIPK1 RASAL1 RASAL1 RTF2 RTF2 KDM6B KDM6B SLC25A12 SLC25A12 TNFAIP3 TNFAIP3 NT5E NT5E ZC3H12A ZC3H12A THBS1 THBS1 RYR2 RYR2 CPNE5 CPNE5 PRDX1 PRDX1 RIPK3 RIPK3 CPNE9 CPNE9 ADA ADA PCGF2 PCGF2 HESX1 HESX1 FANCC FANCC ITPKC ITPKC CAPN3 CAPN3 MCOLN1 MCOLN1 ENSECAP00000053512 ENSECAP00000053512 MFAP2 MFAP2 CACNA1G CACNA1G RHOD RHOD NFE2L2 NFE2L2 GUCA1A GUCA1A DMTN DMTN ENSECAP00000051121 ENSECAP00000051121 ENSECAP00000050619 ENSECAP00000050619 SLC13A5 SLC13A5 CPS1 CPS1 AQP1 AQP1 TREX1 TREX1 HIF1A HIF1A MAPK1 MAPK1 SYT9 SYT9 DLG4 DLG4 GRIA1 GRIA1 TRPC3 TRPC3 SYT7 SYT7 SELENOW SELENOW SYT8 SYT8 KHK KHK CAPN9 CAPN9 SPHK1 SPHK1 CPNE3 CPNE3 CAT CAT ENSECAP00000042890 ENSECAP00000042890 CD14 CD14 SOD3 SOD3 SOD1 SOD1 ENSECAP00000041588 ENSECAP00000041588 NCSTN NCSTN MAPK13 MAPK13 AOC1 AOC1 ENSECAP00000040951 ENSECAP00000040951 TXNRD2 TXNRD2 TRPV5 TRPV5 CAV1 CAV1 CHP2 CHP2 ENSECAP00000040460 ENSECAP00000040460 ECT2 ECT2 IQGAP1 IQGAP1 GPLD1 GPLD1 MAP3K5 MAP3K5 VCP VCP AHCYL1 AHCYL1 ADCY7 ADCY7 HDAC6 HDAC6 EDNRB EDNRB CHUK CHUK KCNMB3 KCNMB3 LOC106782966 LOC106782966 ALPL ALPL IGFBP2 IGFBP2 NEK7 NEK7 SYT13 SYT13 PPP3CA PPP3CA EGFR EGFR ANKH ANKH GPHN GPHN MAPK9 MAPK9 ENSECAP00000034428 ENSECAP00000034428 SYT6 SYT6 ENSECAP00000033542 ENSECAP00000033542 JUND JUND ALOX5AP ALOX5AP FABP4 FABP4 SLC25A23 SLC25A23 CPNE8 CPNE8 PLCG2 PLCG2 ATP7B ATP7B ABL1 ABL1 PRNP PRNP LOC111772122 LOC111772122 CDKN1C CDKN1C SIRT1 SIRT1 TFAP2A TFAP2A TRPC1 TRPC1 ITPKB ITPKB SYT17 SYT17 RUNX2 RUNX2 BRAF BRAF CLIC4 CLIC4 CPNE6 CPNE6 SLC6A1 SLC6A1 LOC100630653 LOC100630653 SLC25A13 SLC25A13 MT2A MT2A MEF2C MEF2C ENSECAP00000025938 ENSECAP00000025938 FKBP1B FKBP1B IMPACT IMPACT ZNF580 ZNF580 DPEP1 DPEP1 ADORA2A ADORA2A ATRX ATRX KCNMB2 KCNMB2 STK39 STK39 ZFAND1 ZFAND1 SPIDR SPIDR DHX36 DHX36 LOXL2 LOXL2 ADCY1 ADCY1 HFE HFE NOS3 NOS3 TFR2 TFR2 CASR CASR SLC30A5 SLC30A5 SUCNR1 SUCNR1 SLC18A2 SLC18A2 PKD2 PKD2 LOC100060748 LOC100060748 JUN JUN TRPM2 TRPM2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SETXSenataxin. (2680 aa)
ADAM9ADAM metallopeptidase domain 9. (819 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1206 aa)
DDI1DNA damage inducible 1 homolog 1. (400 aa)
FIBINFin bud initiation factor homolog; Belongs to the FIBIN family. (216 aa)
SYT5Synaptotagmin 5. (386 aa)
TIMELESSTimeless circadian regulator. (1211 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2020 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
SLC30A1Solute carrier family 30 member 1. (504 aa)
FOXO1Forkhead box O1. (651 aa)
F6W654_HORSESuperoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (216 aa)
HSF1Heat shock transcription factor 1. (535 aa)
LOC111767444Metallothionein-1A; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. (61 aa)
HMOX1Heme oxygenase 1. (490 aa)
DDI2DNA damage inducible 1 homolog 2. (399 aa)
S100A16Protein S100; Belongs to the S-100 family. (103 aa)
PTCH1Patched 1. (1490 aa)
LOC100630858Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
TRPA1Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1120 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (658 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (388 aa)
AQP2Aquaporin-2; Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
PKD2L1Polycystin 2 like 1, transient receptor potential cation channel. (840 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
RASGRP2RAS guanyl releasing protein 2. (608 aa)
STIM1Stromal interaction molecule 1. (791 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2359 aa)
LOC102149958Uncharacterized protein. (149 aa)
CCSCopper chaperone for superoxide dismutase. (274 aa)
GLRA1Glycine receptor alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (457 aa)
LOC100072585Uncharacterized protein. (983 aa)
PRKAA1Non-specific serine/threonine protein kinase. (633 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa)
PAMPeptidylglycine alpha-amidating monooxygenase. (1006 aa)
HVCN1Hydrogen voltage gated channel 1. (271 aa)
LOC100064042Uncharacterized protein. (417 aa)
GSSGlutathione synthetase. (474 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
NET1Neuroepithelial cell transforming 1. (596 aa)
PEF1Penta-EF-hand domain containing 1. (289 aa)
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (619 aa)
DAXXDeath domain associated protein. (748 aa)
PDCD6Programmed cell death 6. (189 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (244 aa)
CPNE7Copine 7. (558 aa)
BAP1Ubiquitin carboxyl-terminal hydrolase. (726 aa)
NQO1NAD(P)H quinone dehydrogenase 1. (274 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1358 aa)
MIEN1Migration and invasion enhancer 1. (115 aa)
ZNF277Zinc finger protein 277. (456 aa)
BMP6Bone morphogenetic protein 6. (506 aa)
ANXA11Annexin. (507 aa)
SIGMAR1Sigma non-opioid intracellular receptor 1. (223 aa)
GSK3AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (483 aa)
SLC1A3Solute carrier family 1 member 3. (542 aa)
SYT11Synaptotagmin 11. (441 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (560 aa)
CPNE2Copine 2. (548 aa)
CPNE4Copine 4. (584 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (298 aa)
FXNFrataxin. (211 aa)
ITPKAKinase; Belongs to the inositol phosphokinase (IPK) family. (461 aa)
OSER1Oxidative stress responsive serine rich 1. (292 aa)
SLC41A1Solute carrier family 41 member 1. (514 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (321 aa)
HAAO3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. (315 aa)
PDCD10Programmed cell death 10. (212 aa)
STK25Serine/threonine kinase 25. (426 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
CARFCalcium responsive transcription factor. (719 aa)
SYT4Synaptotagmin 4. (577 aa)
BNIP3BCL2 interacting protein 3. (243 aa)
SLC30A8Solute carrier family 30 member 8. (369 aa)
MTF1Metal regulatory transcription factor 1. (753 aa)
SLC34A1Solute carrier family 34 member 1. (639 aa)
PRDX3Peroxiredoxin 3. (374 aa)
PARK7Parkinsonism associated deglycase. (268 aa)
SYT10Synaptotagmin 10. (523 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (231 aa)
ABCB6ATP binding cassette subfamily B member 6. (845 aa)
ATF1Activating transcription factor 1. (310 aa)
ANKZF1Ankyrin repeat and zinc finger domain containing 1. (723 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (346 aa)
CUTACutA divalent cation tolerance homolog. (176 aa)
SYT3Synaptotagmin 3. (591 aa)
ACO1Aconitase 1; Belongs to the aconitase/IPM isomerase family. (939 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
SLC12A3Solute carrier family 12 member 3. (1044 aa)
GLRX2Glutaredoxin 2. (148 aa)
NCF1Neutrophil cytosolic factor 1. (392 aa)
SLC38A2Solute carrier family 38 member 2. (506 aa)
LOC100630794Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
MT3Metallothionein-3; Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium; Belongs to the metallothionein superfamily. Type 1 family. (68 aa)
PLEKHA1Pleckstrin homology domain containing A1. (438 aa)
CER1Cerberus 1, DAN family BMP antagonist. (273 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1484 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (381 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (281 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
GLRA2Glycine receptor alpha 2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (452 aa)
MT4Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (62 aa)
KCNMB4Potassium calcium-activated channel subfamily M regulatory beta subunit 4. (210 aa)
STK26Serine/threonine kinase 26. (750 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (811 aa)
HOMER1Homer scaffold protein 1. (296 aa)
ADPRHL2ADP-ribosylhydrolase like 2. (365 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (1043 aa)
TXNThioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...] (105 aa)
ADD1Adducin 1. (771 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
LOC111770212C-C motif chemokine. (100 aa)
RNF112Ring finger protein 112. (629 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
SYT1Synaptotagmin 1. (422 aa)
SMPD1Sphingomyelin phosphodiesterase 1. (824 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1278 aa)
F6SJC9_HORSEIg-like domain-containing protein. (324 aa)
CRYABCrystallin alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (174 aa)
SLC30A10Solute carrier family 30 member 10. (479 aa)
SRCTyrosine-protein kinase. (551 aa)
SOD2Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
ALG2ALG2 alpha-1,3/1,6-mannosyltransferase. (520 aa)
SLC30A3Solute carrier family 30 member 3. (388 aa)
MEF2AMyocyte-specific enhancer factor 2A isoform 1. (502 aa)
EDN1Endothelin 1. (202 aa)
PRDX2Peroxiredoxin 2. (198 aa)
BLMBLM RecQ like helicase. (1430 aa)
NFATC4Nuclear factor of activated T cells 4. (932 aa)
SYT2Synaptotagmin 2. (419 aa)
LRRK2Leucine rich repeat kinase 2. (2528 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
LGMNLegumain. (433 aa)
SLC30A2Solute carrier family 30 member 2. (555 aa)
FGBFibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it i [...] (495 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
RASAL1RAS protein activator like 1. (926 aa)
RTF2Replication termination factor 2. (306 aa)
KDM6BLysine demethylase 6B. (1636 aa)
SLC25A12Solute carrier family 25 member 12; Belongs to the mitochondrial carrier (TC 2.A.29) family. (682 aa)
TNFAIP3TNF alpha induced protein 3. (794 aa)
NT5E5'-nucleotidase ecto. (807 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (615 aa)
THBS1Thrombospondin 1. (1170 aa)
RYR2Ryanodine receptor 2. (4967 aa)
CPNE5Copine 5. (593 aa)
PRDX1Peroxiredoxin 1. (199 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (513 aa)
CPNE9Copine family member 9. (553 aa)
ADAAdenosine deaminase. (363 aa)
PCGF2Polycomb group ring finger 2. (344 aa)
HESX1HESX homeobox 1. (185 aa)
FANCCFA complementation group C. (623 aa)
ITPKCKinase; Belongs to the inositol phosphokinase (IPK) family. (666 aa)
CAPN3Calpain 3; Belongs to the peptidase C2 family. (821 aa)
MCOLN1Mucolipin 1. (712 aa)
ENSECAP00000053512Uncharacterized protein; Belongs to the metallothionein superfamily. Type 1 family. (118 aa)
MFAP2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1387 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2378 aa)
RHODSynaptotagmin 12. (530 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (605 aa)
GUCA1AGuanylate cyclase activator 1A. (205 aa)
DMTNDematin actin binding protein. (405 aa)
ENSECAP00000051121KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
ENSECAP00000050619Thioredoxin domain-containing protein. (199 aa)
SLC13A5Solute carrier family 13 member 5. (707 aa)
CPS1Carbamoyl-phosphate synthase 1. (1521 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (307 aa)
TREX1Three prime repair exonuclease 1. (314 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (844 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (594 aa)
SYT9Olfactomedin like 1. (848 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (767 aa)
GRIA1Glutamate ionotropic receptor AMPA type subunit 1. (906 aa)
TRPC3Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (920 aa)
SYT7Synaptotagmin 7. (828 aa)
SELENOWSelenoprotein W. (302 aa)
SYT8Synaptotagmin 8. (453 aa)
KHKKetohexokinase. (298 aa)
CAPN9Calpain 9; Belongs to the peptidase C2 family. (712 aa)
SPHK1Sphingosine kinase 1. (459 aa)
CPNE3Copine 3. (533 aa)
CATCatalase. (598 aa)
ENSECAP00000042890Uncharacterized protein. (145 aa)
CD14CD14 molecule. (369 aa)
SOD3Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (296 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (171 aa)
ENSECAP00000041588Uncharacterized protein. (152 aa)
NCSTNNicastrin. (709 aa)
MAPK13Mitogen-activated protein kinase. (421 aa)
AOC1Amine oxidase. (793 aa)
ENSECAP00000040951Sep15_SelM domain-containing protein. (294 aa)
TXNRD2Thioredoxin reductase 2; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. (576 aa)
TRPV5Transient receptor potential cation channel subfamily V member 6; Belongs to the transient receptor (TC 1.A.4) family. (799 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
CHP2Calcineurin like EF-hand protein 2. (428 aa)
ENSECAP00000040460Uncharacterized protein. (104 aa)
ECT2Epithelial cell transforming 2. (1042 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (2101 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (867 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1362 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (822 aa)
AHCYL1Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family. (691 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
HDAC6Histone deacetylase 6. (1266 aa)
EDNRBEndothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. (447 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
KCNMB3Potassium calcium-activated channel subfamily M regulatory beta subunit 3. (275 aa)
LOC106782966Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (75 aa)
ALPLAlkaline phosphatase. (574 aa)
IGFBP2Insulin like growth factor binding protein 2. (326 aa)
NEK7NIMA related kinase 7; Belongs to the protein kinase superfamily. (432 aa)
SYT13Synaptotagmin 13. (437 aa)
PPP3CASerine/threonine-protein phosphatase. (717 aa)
EGFRReceptor protein-tyrosine kinase. (1195 aa)
ANKHANKH inorganic pyrophosphate transport regulator. (864 aa)
GPHNGephyrin. (829 aa)
MAPK9Mitogen-activated protein kinase. (446 aa)
ENSECAP00000034428Uncharacterized protein. (97 aa)
SYT6Synaptotagmin 6. (528 aa)
ENSECAP00000033542Uncharacterized protein. (170 aa)
JUNDJunD proto-oncogene, AP-1 transcription factor subunit. (349 aa)
ALOX5APArachidonate 5-lipoxygenase-activating protein; Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes (By similarity); Belongs to the MAPEG family. (187 aa)
FABP4Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (183 aa)
SLC25A23Solute carrier family 25 member 23; Belongs to the mitochondrial carrier (TC 2.A.29) family. (473 aa)
CPNE8Copine 8. (577 aa)
PLCG2Phosphoinositide phospholipase C. (1331 aa)
ATP7BATPase copper transporting beta. (1493 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
PRNPMajor prion protein; Belongs to the prion family. (255 aa)
LOC111772122Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (369 aa)
CDKN1CCyclin dependent kinase inhibitor 1C. (328 aa)
SIRT1Sirtuin 1. (737 aa)
TFAP2ATranscription factor AP-2 alpha. (449 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (792 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (1008 aa)
SYT17Synaptotagmin 17. (502 aa)
RUNX2Runt-related transcription factor 2; Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. Inhibits KAT6B-dependent transcriptional activation. In osteoblasts, supports transcription activati [...] (634 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (793 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (278 aa)
CPNE6Copine 6. (632 aa)
SLC6A1Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (631 aa)
LOC100630653Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
SLC25A13Solute carrier family 25 member 13; Belongs to the mitochondrial carrier (TC 2.A.29) family. (687 aa)
MT2AMetallothionein-1B; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids; Belongs to the metallothionein superfamily. Type 1 family. (61 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
ENSECAP00000025938Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (83 aa)
FKBP1BPeptidylprolyl isomerase. (223 aa)
IMPACTImpact RWD domain protein. (359 aa)
ZNF580Zinc finger protein 580. (172 aa)
DPEP1Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (497 aa)
ADORA2AAdenosine receptor A2a; Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). (412 aa)
ATRXATRX chromatin remodeler. (2489 aa)
KCNMB2Potassium calcium-activated channel subfamily M regulatory beta subunit 2. (284 aa)
STK39Serine/threonine kinase 39. (556 aa)
ZFAND1Zinc finger AN1-type containing 1. (377 aa)
SPIDRScaffold protein involved in DNA repair. (906 aa)
DHX36DEAH-box helicase 36. (1029 aa)
LOXL2Lysyl oxidase like 2. (1047 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1124 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (361 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1267 aa)
TFR2Transferrin receptor 2. (945 aa)
CASRCalcium sensing receptor. (1084 aa)
SLC30A5Solute carrier family 30 member 5. (766 aa)
SUCNR1Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family. (350 aa)
SLC18A2Solute carrier family 18 member A2. (517 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (958 aa)
LOC100060748Uncharacterized protein. (1033 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (340 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1524 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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