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ABCB6 ABCB6 SYT10 SYT10 PARK7 PARK7 SLC34A1 SLC34A1 MTF1 MTF1 SLC30A8 SLC30A8 BNIP3 BNIP3 SYT4 SYT4 CARF CARF HAAO HAAO CRHBP CRHBP SLC41A1 SLC41A1 ITPKA ITPKA FXN FXN TIGAR TIGAR CPNE4 CPNE4 CPNE2 CPNE2 SYT11 SYT11 GSK3A GSK3A ANXA11 ANXA11 BMP6 BMP6 CPNE7 CPNE7 PDCD6 PDCD6 DAXX DAXX PEF1 PEF1 GSS GSS LOC100064042 LOC100064042 HVCN1 HVCN1 PAM PAM ACER1 ACER1 PRKAA1 PRKAA1 GLRA1 GLRA1 LOC102149958 LOC102149958 CACNA1H CACNA1H STIM1 STIM1 RASGRP2 RASGRP2 CDKN1B CDKN1B IL1A IL1A MNAT1 MNAT1 AQP2 AQP2 P2RX4 P2RX4 TRPM2 TRPM2 JUN JUN LOC100060748 LOC100060748 PKD2 PKD2 SLC18A2 SLC18A2 CPNE8 CPNE8 PLCG2 PLCG2 ATP7B ATP7B PRNP PRNP LOC111772122 LOC111772122 CDKN1C CDKN1C MEF2C MEF2C ENSECAP00000025938 ENSECAP00000025938 DPEP1 DPEP1 KCNMB2 KCNMB2 STK39 STK39 LOXL2 LOXL2 ADCY1 ADCY1 HFE HFE TFR2 TFR2 CASR CASR SLC30A5 SLC30A5 CAPN3 CAPN3 MCOLN1 MCOLN1 SUCNR1 SUCNR1 SMPD3 SMPD3 LOC100630858 LOC100630858 ENSECAP00000053512 ENSECAP00000053512 MFAP2 MFAP2 CACNA1G CACNA1G RHOD RHOD NFE2L2 NFE2L2 GUCA1A GUCA1A DMTN DMTN SLC13A5 SLC13A5 AQP1 AQP1 HIF1A HIF1A MAPK1 MAPK1 SYT9 SYT9 DLG4 DLG4 S100A16 S100A16 HMOX1 HMOX1 LOC111767444 LOC111767444 HSF1 HSF1 SLC30A1 SLC30A1 JUNB JUNB TRPC3 TRPC3 SYT7 SYT7 SYT8 SYT8 KHK KHK CAPN9 CAPN9 CPNE3 CPNE3 CD14 CD14 ENSECAP00000041588 ENSECAP00000041588 NCSTN NCSTN SCN5A SCN5A SYT5 SYT5 FIBIN FIBIN ADAM9 ADAM9 ITPKC ITPKC HESX1 HESX1 CPNE9 CPNE9 AOC1 AOC1 CPNE5 CPNE5 RYR2 RYR2 THBS1 THBS1 SLC25A12 SLC25A12 RASAL1 RASAL1 P2RX7 P2RX7 FGB FGB SLC30A2 SLC30A2 LGMN LGMN TCIRG1 TCIRG1 LRRK2 LRRK2 SYT2 SYT2 TRPV5 TRPV5 CAV1 CAV1 CHP2 CHP2 ENSECAP00000040460 ENSECAP00000040460 ECT2 ECT2 IQGAP1 IQGAP1 GPLD1 GPLD1 AHCYL1 AHCYL1 NFATC4 NFATC4 MEF2A MEF2A SLC30A3 SLC30A3 ALG2 ALG2 SLC30A10 SLC30A10 F6SJC9_HORSE F6SJC9_HORSE ADCY7 ADCY7 CHUK CHUK KCNMB3 KCNMB3 LOC106782966 LOC106782966 IGFBP2 IGFBP2 KCNMA1 KCNMA1 NEK7 NEK7 SYT13 SYT13 PPP3CA PPP3CA EGFR EGFR GPHN GPHN MAPK9 MAPK9 ENSECAP00000034428 ENSECAP00000034428 SYT6 SYT6 ENSECAP00000033542 ENSECAP00000033542 JUND JUND SMPD1 SMPD1 SYT1 SYT1 TFAP2A TFAP2A TRPC1 TRPC1 ITPKB ITPKB SYT17 SYT17 BRAF BRAF CLIC4 CLIC4 CPNE6 CPNE6 LOC100630653 LOC100630653 SLC25A13 SLC25A13 MT2A MT2A ALOX5AP ALOX5AP FABP4 FABP4 PRKAA2 PRKAA2 ADD1 ADD1 HOMER1 HOMER1 KCNMB4 KCNMB4 MT4 MT4 GLRA2 GLRA2 CREB1 CREB1 FOS FOS MAPK3 MAPK3 CER1 CER1 MT3 MT3 LOC100630794 LOC100630794 SLC25A23 SLC25A23 NCF1 NCF1 ACO1 ACO1 SYT3 SYT3 CUTA CUTA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ABCB6ATP binding cassette subfamily B member 6. (845 aa)
SYT10Synaptotagmin 10. (523 aa)
PARK7Parkinsonism associated deglycase. (268 aa)
SLC34A1Solute carrier family 34 member 1. (639 aa)
MTF1Metal regulatory transcription factor 1. (753 aa)
SLC30A8Solute carrier family 30 member 8. (369 aa)
BNIP3BCL2 interacting protein 3. (243 aa)
SYT4Synaptotagmin 4. (577 aa)
CARFCalcium responsive transcription factor. (719 aa)
HAAO3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. (315 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (321 aa)
SLC41A1Solute carrier family 41 member 1. (514 aa)
ITPKAKinase; Belongs to the inositol phosphokinase (IPK) family. (461 aa)
FXNFrataxin. (211 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (298 aa)
CPNE4Copine 4. (584 aa)
CPNE2Copine 2. (548 aa)
SYT11Synaptotagmin 11. (441 aa)
GSK3AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (483 aa)
ANXA11Annexin. (507 aa)
BMP6Bone morphogenetic protein 6. (506 aa)
CPNE7Copine 7. (558 aa)
PDCD6Programmed cell death 6. (189 aa)
DAXXDeath domain associated protein. (748 aa)
PEF1Penta-EF-hand domain containing 1. (289 aa)
GSSGlutathione synthetase. (474 aa)
LOC100064042Uncharacterized protein. (417 aa)
HVCN1Hydrogen voltage gated channel 1. (271 aa)
PAMPeptidylglycine alpha-amidating monooxygenase. (1006 aa)
ACER1Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (264 aa)
PRKAA1Non-specific serine/threonine protein kinase. (633 aa)
GLRA1Glycine receptor alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (457 aa)
LOC102149958Uncharacterized protein. (149 aa)
CACNA1HCalcium voltage-gated channel subunit alpha1 H. (2359 aa)
STIM1Stromal interaction molecule 1. (791 aa)
RASGRP2RAS guanyl releasing protein 2. (608 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (198 aa)
IL1AInterleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
AQP2Aquaporin-2; Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (388 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1524 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (340 aa)
LOC100060748Uncharacterized protein. (1033 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (958 aa)
SLC18A2Solute carrier family 18 member A2. (517 aa)
CPNE8Copine 8. (577 aa)
PLCG2Phosphoinositide phospholipase C. (1331 aa)
ATP7BATPase copper transporting beta. (1493 aa)
PRNPMajor prion protein; Belongs to the prion family. (255 aa)
LOC111772122Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (369 aa)
CDKN1CCyclin dependent kinase inhibitor 1C. (328 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
ENSECAP00000025938Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (83 aa)
DPEP1Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (497 aa)
KCNMB2Potassium calcium-activated channel subfamily M regulatory beta subunit 2. (284 aa)
STK39Serine/threonine kinase 39. (556 aa)
LOXL2Lysyl oxidase like 2. (1047 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1124 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (361 aa)
TFR2Transferrin receptor 2. (945 aa)
CASRCalcium sensing receptor. (1084 aa)
SLC30A5Solute carrier family 30 member 5. (766 aa)
CAPN3Calpain 3; Belongs to the peptidase C2 family. (821 aa)
MCOLN1Mucolipin 1. (712 aa)
SUCNR1Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family. (350 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (658 aa)
LOC100630858Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
ENSECAP00000053512Uncharacterized protein; Belongs to the metallothionein superfamily. Type 1 family. (118 aa)
MFAP2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1387 aa)
CACNA1GVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2378 aa)
RHODSynaptotagmin 12. (530 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (605 aa)
GUCA1AGuanylate cyclase activator 1A. (205 aa)
DMTNDematin actin binding protein. (405 aa)
SLC13A5Solute carrier family 13 member 5. (707 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (307 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (844 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (594 aa)
SYT9Olfactomedin like 1. (848 aa)
DLG4Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family. (767 aa)
S100A16Protein S100; Belongs to the S-100 family. (103 aa)
HMOX1Heme oxygenase 1. (490 aa)
LOC111767444Metallothionein-1A; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. (61 aa)
HSF1Heat shock transcription factor 1. (535 aa)
SLC30A1Solute carrier family 30 member 1. (504 aa)
JUNBJunB proto-oncogene, AP-1 transcription factor subunit. (347 aa)
TRPC3Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. (920 aa)
SYT7Synaptotagmin 7. (828 aa)
SYT8Synaptotagmin 8. (453 aa)
KHKKetohexokinase. (298 aa)
CAPN9Calpain 9; Belongs to the peptidase C2 family. (712 aa)
CPNE3Copine 3. (533 aa)
CD14CD14 molecule. (369 aa)
ENSECAP00000041588Uncharacterized protein. (152 aa)
NCSTNNicastrin. (709 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2020 aa)
SYT5Synaptotagmin 5. (386 aa)
FIBINFin bud initiation factor homolog; Belongs to the FIBIN family. (216 aa)
ADAM9ADAM metallopeptidase domain 9. (819 aa)
ITPKCKinase; Belongs to the inositol phosphokinase (IPK) family. (666 aa)
HESX1HESX homeobox 1. (185 aa)
CPNE9Copine family member 9. (553 aa)
AOC1Amine oxidase. (793 aa)
CPNE5Copine 5. (593 aa)
RYR2Ryanodine receptor 2. (4967 aa)
THBS1Thrombospondin 1. (1170 aa)
SLC25A12Solute carrier family 25 member 12; Belongs to the mitochondrial carrier (TC 2.A.29) family. (682 aa)
RASAL1RAS protein activator like 1. (926 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
FGBFibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it i [...] (495 aa)
SLC30A2Solute carrier family 30 member 2. (555 aa)
LGMNLegumain. (433 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
LRRK2Leucine rich repeat kinase 2. (2528 aa)
SYT2Synaptotagmin 2. (419 aa)
TRPV5Transient receptor potential cation channel subfamily V member 6; Belongs to the transient receptor (TC 1.A.4) family. (799 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
CHP2Calcineurin like EF-hand protein 2. (428 aa)
ENSECAP00000040460Uncharacterized protein. (104 aa)
ECT2Epithelial cell transforming 2. (1042 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (2101 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (867 aa)
AHCYL1Adenosylhomocysteinase like 1; Belongs to the adenosylhomocysteinase family. (691 aa)
NFATC4Nuclear factor of activated T cells 4. (932 aa)
MEF2AMyocyte-specific enhancer factor 2A isoform 1. (502 aa)
SLC30A3Solute carrier family 30 member 3. (388 aa)
ALG2ALG2 alpha-1,3/1,6-mannosyltransferase. (520 aa)
SLC30A10Solute carrier family 30 member 10. (479 aa)
F6SJC9_HORSEIg-like domain-containing protein. (324 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
KCNMB3Potassium calcium-activated channel subfamily M regulatory beta subunit 3. (275 aa)
LOC106782966Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (75 aa)
IGFBP2Insulin like growth factor binding protein 2. (326 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1278 aa)
NEK7NIMA related kinase 7; Belongs to the protein kinase superfamily. (432 aa)
SYT13Synaptotagmin 13. (437 aa)
PPP3CASerine/threonine-protein phosphatase. (717 aa)
EGFRReceptor protein-tyrosine kinase. (1195 aa)
GPHNGephyrin. (829 aa)
MAPK9Mitogen-activated protein kinase. (446 aa)
ENSECAP00000034428Uncharacterized protein. (97 aa)
SYT6Synaptotagmin 6. (528 aa)
ENSECAP00000033542Uncharacterized protein. (170 aa)
JUNDJunD proto-oncogene, AP-1 transcription factor subunit. (349 aa)
SMPD1Sphingomyelin phosphodiesterase 1. (824 aa)
SYT1Synaptotagmin 1. (422 aa)
TFAP2ATranscription factor AP-2 alpha. (449 aa)
TRPC1Transient receptor potential cation channel subfamily C member 1; Belongs to the transient receptor (TC 1.A.4) family. (792 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (1008 aa)
SYT17Synaptotagmin 17. (502 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (793 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (278 aa)
CPNE6Copine 6. (632 aa)
LOC100630653Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
SLC25A13Solute carrier family 25 member 13; Belongs to the mitochondrial carrier (TC 2.A.29) family. (687 aa)
MT2AMetallothionein-1B; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids; Belongs to the metallothionein superfamily. Type 1 family. (61 aa)
ALOX5APArachidonate 5-lipoxygenase-activating protein; Required for leukotriene biosynthesis by ALOX5 (5- lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes (By similarity); Belongs to the MAPEG family. (187 aa)
FABP4Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (183 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
ADD1Adducin 1. (771 aa)
HOMER1Homer scaffold protein 1. (296 aa)
KCNMB4Potassium calcium-activated channel subfamily M regulatory beta subunit 4. (210 aa)
MT4Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (62 aa)
GLRA2Glycine receptor alpha 2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (452 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (381 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
CER1Cerberus 1, DAN family BMP antagonist. (273 aa)
MT3Metallothionein-3; Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium; Belongs to the metallothionein superfamily. Type 1 family. (68 aa)
LOC100630794Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
SLC25A23Solute carrier family 25 member 23; Belongs to the mitochondrial carrier (TC 2.A.29) family. (473 aa)
NCF1Neutrophil cytosolic factor 1. (392 aa)
ACO1Aconitase 1; Belongs to the aconitase/IPM isomerase family. (939 aa)
SYT3Synaptotagmin 3. (591 aa)
CUTACutA divalent cation tolerance homolog. (176 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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