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| | RRAGA | Ras related GTP binding A. (313 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa) |
| | TPCN2 | Two pore segment channel 2. (1006 aa) |
| | SVIP | Uncharacterized protein. (225 aa) |
| | DCAF12L2 | WD_REPEATS_REGION domain-containing protein. (463 aa) |
| | KIAA0408 | KIAA0408. (696 aa) |
| | MTM1 | Myotubularin 1. (636 aa) |
| | LOC100060012 | DDB1- and CUL4-associated factor 12-like protein 2. (390 aa) |
| | AMBRA1 | Autophagy and beclin 1 regulator 1. (1299 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (381 aa) |
| | WAC | WW domain containing adaptor with coiled-coil. (1112 aa) |
| | TMEM59 | Transmembrane protein 59. (378 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (569 aa) |
| | FBXL2 | F-box and leucine rich repeat protein 2. (503 aa) |
| | ENSECAP00000033993 | MitoNEET_N domain-containing protein. (111 aa) |
| | PHF23 | PHD finger protein 23. (403 aa) |
| | SUPT5H | Transcription elongation factor SPT5. (1087 aa) |
| | LEP | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (189 aa) |
| | SNX4 | Sorting nexin 4. (475 aa) |
| | MTMR8 | Myotubularin related protein 8. (926 aa) |
| | STAT3 | Signal transducer and activator of transcription. (770 aa) |
| | C23H9orf72 | Chromosome 23 C9orf72 homolog. (481 aa) |
| | HDAC6 | Histone deacetylase 6. (1266 aa) |
| | ATG16L1 | Autophagy related 16 like 1. (914 aa) |
| | PIP4K2C | Phosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (591 aa) |
| | BCL2 | BCL2 apoptosis regulator. (285 aa) |
| | MTCL1 | Microtubule crosslinking factor 1. (2026 aa) |
| | POLDIP2 | DNA polymerase delta interacting protein 2. (559 aa) |
| | ATG14 | Autophagy related 14. (510 aa) |
| | SH3BP4 | SH3 domain binding protein 4. (964 aa) |
| | GPR137B | G protein-coupled receptor 137B. (419 aa) |
| | ENSECAP00000040460 | Uncharacterized protein. (104 aa) |
| | RAB3GAP1 | RAB3 GTPase activating protein catalytic subunit 1. (989 aa) |
| | PAFAH1B2 | Platelet-activating factor acetylhydrolase I subunit beta-like protein. (229 aa) |
| | TRIM27 | Tripartite motif containing 27. (536 aa) |
| | NOD1 | Nucleotide binding oligomerization domain containing 1. (993 aa) |
| | SPTLC2 | Serine palmitoyltransferase long chain base subunit 2. (597 aa) |
| | TFEB | Transcription factor EB. (522 aa) |
| | ENSECAP00000043258 | Uncharacterized protein. (241 aa) |
| | UBQLN4 | Ubiquilin 4. (615 aa) |
| | ATF6 | Activating transcription factor 6. (669 aa) |
| | WIPI1 | WD repeat domain, phosphoinositide interacting 1. (456 aa) |
| | NPRL3 | NPR3 like, GATOR1 complex subunit. (664 aa) |
| | CDK16 | Cyclin dependent kinase 16. (573 aa) |
| | CTTN | Cortactin. (559 aa) |
| | PLEKHF1 | Pleckstrin homology and FYVE domain containing 1. (330 aa) |
| | PIP4K2A | Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (587 aa) |
| | SESN1 | Sestrin 1. (551 aa) |
| | TBC1D14 | TBC1 domain family member 14. (693 aa) |
| | CLEC16A | C-type lectin domain containing 16A. (1048 aa) |
| | HIF1A | Hypoxia inducible factor 1 subunit alpha. (844 aa) |
| | CISD1 | ZnF_CDGSH domain-containing protein. (128 aa) |
| | RB1CC1 | RB1 inducible coiled-coil 1. (1637 aa) |
| | DNM1L | Dynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (749 aa) |
| | MTOR | Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2573 aa) |
| | XBP1 | BZIP domain-containing protein. (378 aa) |
| | MTMR9 | Myotubularin related protein 9. (550 aa) |
| | DAPK1 | Death associated protein kinase 1. (1457 aa) |
| | MFAP2 | Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1387 aa) |
| | ATG13 | Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa) |
| | FBXW9 | F-box and WD repeat domain containing 9. (477 aa) |
| | CALCOCO2 | Calcium binding and coiled-coil domain 2. (502 aa) |
| | PRKN | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (466 aa) |
| | RNF5 | Ring finger protein 5. (241 aa) |
| | BNIP3 | BCL2 interacting protein 3. (243 aa) |
| | NOD2 | Nucleotide binding oligomerization domain containing 2. (1013 aa) |
| | ATP6V0A1 | V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (839 aa) |
| | QSOX1 | Sulfhydryl oxidase. (752 aa) |
| | ACER2 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (274 aa) |
| | CHMP4A | Charged multivesicular body protein 4A. (264 aa) |
| | TPCN1 | Two pore segment channel 1. (818 aa) |
| | VPS13D | Vacuolar protein sorting 13 homolog D. (4388 aa) |
| | TRIM8 | Tripartite motif containing 8. (551 aa) |
| | ULK1 | Unc-51 like autophagy activating kinase 1. (1059 aa) |
| | SMCR8 | SMCR8-C9orf72 complex subunit. (937 aa) |
| | RRAGD | Ras related GTP binding D. (397 aa) |
| | TRIM34 | Uncharacterized protein. (496 aa) |
| | DAPL1 | Death associated protein like 1. (101 aa) |
| | KLHL22 | Kelch like family member 22. (634 aa) |
| | TREM2 | Triggering receptor expressed on myeloid cells 2. (298 aa) |
| | DEPDC5 | DEP domain containing 5. (1602 aa) |
| | MT3 | Metallothionein-3; Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium; Belongs to the metallothionein superfamily. Type 1 family. (68 aa) |
| | GPR137 | G protein-coupled receptor 137. (477 aa) |
| | IL10RA | Interleukin 10 receptor subunit alpha. (572 aa) |
| | STK11 | Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa) |
| | NUPR1 | Nuclear protein 1, transcriptional regulator. (82 aa) |
| | RALB | RAS like proto-oncogene B. (206 aa) |
| | LEPR | Leptin receptor. (1165 aa) |
| | F7CNV6_HORSE | Uncharacterized protein. (1071 aa) |
| | SNX18 | Sorting nexin. (624 aa) |
| | ATG2A | Autophagy related 2A. (1935 aa) |
| | SEC22B | SEC22 homolog B, vesicle trafficking protein; Belongs to the synaptobrevin family. (239 aa) |
| | SOGA1 | Suppressor of glucose, autophagy associated 1. (2201 aa) |
| | SMG1 | SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3660 aa) |
| | ATG5 | Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa) |
| | TMEM39B | Transmembrane protein 39B. (492 aa) |
| | FYCO1 | FYVE and coiled-coil domain containing 1. (1478 aa) |
| | PRKAA2 | Non-specific serine/threonine protein kinase. (552 aa) |
| | JMJD8 | WD repeat domain 24. (1023 aa) |
| | VDAC1 | Voltage dependent anion channel 1. (364 aa) |
| | ATG12 | Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (140 aa) |
| | TRIML2 | Tripartite motif family like 2. (427 aa) |
| | MID2 | Midline 2. (735 aa) |
| | BTNL9 | Butyrophilin like 9. (545 aa) |
| | TRIML1 | Tripartite motif family like 1. (462 aa) |
| | SNX30 | Sorting nexin family member 30. (459 aa) |
| | TRIM13 | Tripartite motif containing 13. (409 aa) |
| | DRAM2 | DNA damage regulated autophagy modulator 2. (549 aa) |
| | RUFY4 | RUN and FYVE domain containing 4. (572 aa) |
| | TP53INP2 | Tumor protein p53 inducible nuclear protein 2. (221 aa) |
| | PIK3C3 | Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa) |
| | LRRK2 | Leucine rich repeat kinase 2. (2528 aa) |
| | ERCC4 | ERCC excision repair 4, endonuclease catalytic subunit. (916 aa) |
| | CCNY | Cyclin Y; Belongs to the cyclin family. (341 aa) |
| | GFAP | Glial fibrillary acidic protein; Belongs to the intermediate filament family. (559 aa) |
| | PYCARD | PYD and CARD domain containing. (195 aa) |
| | HTT | Huntingtin. (3126 aa) |
| | ENDOG | Endonuclease. (299 aa) |
| | FBXO7 | F-box protein 7. (550 aa) |
| | LOC100055965 | Myotubularin phosphatase domain-containing protein. (739 aa) |
| | ZC3H12A | Zinc finger CCCH-type containing 12A. (615 aa) |
| | PINK1 | PTEN induced kinase 1. (585 aa) |
| | TRIM32 | Tripartite motif containing 32. (653 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (249 aa) |
| | DRAM1 | DNA damage regulated autophagy modulator 1. (238 aa) |
| | HMGB1 | High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...] (215 aa) |
| | IL4 | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (139 aa) |
| | TRIM68 | Tripartite motif containing 68. (484 aa) |
| | OPTN | Optineurin. (574 aa) |
| | ZMPSTE24 | CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa) |
| | MFSD8 | Major facilitator superfamily domain containing 8. (519 aa) |
| | RAB39B | RAB39B, member RAS oncogene family. (213 aa) |
| | PRAF2 | WD repeat domain 45. (361 aa) |
| | MEFV | MEFV innate immuity regulator, pyrin. (117 aa) |
| | RRAGB | Ras related GTP binding B. (374 aa) |
| | RNF41 | Ring finger protein 41. (317 aa) |
| | TP53INP1 | Tumor protein p53 inducible nuclear protein 1. (239 aa) |
| | CLN3 | Battenin. (437 aa) |
| | SESN3 | Sestrin 3. (488 aa) |
| | VPS13C | Vacuolar protein sorting 13 homolog C. (3751 aa) |
| | LRSAM1 | Leucine rich repeat and sterile alpha motif containing 1. (727 aa) |
| | RAB3GAP2 | Uncharacterized protein. (1393 aa) |
| | BECN1 | Beclin 1. (448 aa) |
| | USP10 | Ubiquitin specific peptidase 10; Belongs to the peptidase C19 family. (1006 aa) |
| | KDM4A | Lysine demethylase 4A. (1065 aa) |
| | KAT8 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (459 aa) |
| | ATG101 | Autophagy related 101. (218 aa) |
| | TIGAR | TP53 induced glycolysis regulatory phosphatase. (298 aa) |
| | HTR2B | 5-hydroxytryptamine receptor 2B. (503 aa) |
| | MTMR3 | Myotubularin related protein 3. (1202 aa) |
| | GSK3A | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (483 aa) |
| | RRAGC | Ras related GTP binding C. (399 aa) |
| | LZTS1 | Leucine zipper tumor suppressor 1. (600 aa) |
| | KDR | Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1358 aa) |
| | DCN | Decorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (360 aa) |
| | DDIT3 | DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa) |
| | CISD2 | CDGSH iron sulfur domain 2. (135 aa) |
| | KEAP1 | Kelch like ECH associated protein 1. (593 aa) |
| | TMEM39A | Transmembrane protein 39A. (488 aa) |
| | TRIM65 | Tripartite motif containing 65. (517 aa) |
| | TBK1 | TANK binding kinase 1. (729 aa) |
| | RASIP1 | Ras interacting protein 1. (964 aa) |
| | TSPO | Translocator protein. (308 aa) |
| | ROCK1 | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa) |
| | TSC2 | TSC complex subunit 2. (1817 aa) |
| | PIP4K2B | Phosphatidylinositol-5-phosphate 4-kinase type 2 beta. (439 aa) |
| | PARL | Presenilin associated rhomboid like. (513 aa) |
| | NPRL2 | NPR2 like, GATOR1 complex subunit. (380 aa) |
| | PRKAA1 | Non-specific serine/threonine protein kinase. (633 aa) |
| | FBXW7 | F-box and WD repeat domain containing 7. (754 aa) |
| | BMF | Bcl2 modifying factor. (227 aa) |
| | DCAF12 | DDB1 and CUL4 associated factor 12. (453 aa) |
| | CPTP | Ceramide-1-phosphate transfer protein. (214 aa) |
| | TBC1D25 | TBC1 domain family member 25. (688 aa) |
| | SOGA3 | Uncharacterized protein. (947 aa) |
| | WDR6 | WD repeat domain 6. (1186 aa) |
| | UVRAG | UV radiation resistance associated. (699 aa) |
| | CASP1 | Caspase-1 subunit p10; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive. In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracell [...] (405 aa) |
| | TRIM38 | Tripartite motif containing 38. (464 aa) |
| | FOXO3 | Forkhead box O3. (671 aa) |
| | PIK3R2 | Uncharacterized protein. (479 aa) |
| | USP33 | Ubiquitinyl hydrolase 1. (1062 aa) |
| | FOXK2 | Forkhead box K2. (655 aa) |
| | WDR41 | WD repeat domain 41. (484 aa) |
| | LOC111771735 | WD_REPEATS_REGION domain-containing protein. (390 aa) |
| | SH3GLB1 | SH3 domain containing GRB2 like, endophilin B1. (402 aa) |
| | TRIM6 | Uncharacterized protein. (490 aa) |
| | RPTOR | Regulatory associated protein of MTOR complex 1. (1384 aa) |
| | FLCN | UDENN FLCN/SMCR8-type domain-containing protein. (829 aa) |
| | STING1 | Transmembrane protein 173. (405 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3076 aa) |
| | LARP1 | La ribonucleoprotein domain family member 1. (1387 aa) |
| | PRKD1 | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa) |
| | FEZ1 | Fasciculation and elongation protein zeta 1. (408 aa) |
| | FEZ2 | Fasciculation and elongation protein zeta 2. (383 aa) |
| | SPTLC1 | Serine palmitoyltransferase long chain base subunit 1. (474 aa) |
| | RUBCN | Rubicon autophagy regulator. (1013 aa) |
| | SIRT1 | Sirtuin 1. (737 aa) |
| | SIRT2 | Sirtuin 2. (462 aa) |
| | DAP | Uncharacterized protein. (250 aa) |
| | RMC1 | Regulator of MON1-CCZ1. (869 aa) |
| | SCOC | Short coiled-coil protein. (193 aa) |
| | UFL1 | UFM1 specific ligase 1. (791 aa) |
| | PIK3R4 | Phosphoinositide-3-kinase regulatory subunit 4. (1468 aa) |
| | MTDH | Metadherin. (615 aa) |
| | NLRP6 | NLR family pyrin domain containing 6. (892 aa) |
| | MTMR4 | Myotubularin related protein 4. (1311 aa) |
| | SNX7 | Sorting nexin 7. (471 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa) |
| | BOK | BCL2 family apoptosis regulator BOK. (213 aa) |
| | TRIB3 | Tribbles pseudokinase 3. (353 aa) |
| | HMOX1 | Heme oxygenase 1. (490 aa) |
| | FOXO1 | Forkhead box O1. (651 aa) |
| | F6W876_HORSE | ZnF_CDGSH domain-containing protein. (106 aa) |
| | DEPP1 | DEPP1 autophagy regulator. (196 aa) |
| | SESN2 | Sestrin 2. (481 aa) |
| | TECPR1 | Tectonin beta-propeller repeat containing 1. (1164 aa) |
| | CTSA | Carboxypeptidase; Belongs to the peptidase S10 family. (494 aa) |
| | EHMT2 | Euchromatic histone lysine methyltransferase 2. (1389 aa) |
| | BAG3 | BCL2 associated athanogene 3. (582 aa) |
| | SCFD1 | Sec1 family domain containing 1; Belongs to the STXBP/unc-18/SEC1 family. (641 aa) |
| | RNF152 | Ring finger protein 152. (203 aa) |
| | USP13 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (863 aa) |
| | LOC100054534 | Uncharacterized protein. (511 aa) |
| | TRIM21 | Tripartite motif containing 21. (469 aa) |
