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ATP5F1A ATP5F1A HMOX1 HMOX1 RHOJ RHOJ LOC100054259 LOC100054259 LOC100054308 LOC100054308 FUT1 FUT1 PIK3CD PIK3CD HMGB1 HMGB1 AKT2 AKT2 MAP3K3 MAP3K3 THBS1 THBS1 ZC3H12A ZC3H12A ANGPT4 ANGPT4 VEGFA VEGFA LGMN LGMN NUS1 NUS1 MET MET TGFB1 TGFB1 FGF2 FGF2 AAMP AAMP LOC100062428 LOC100062428 AGT AGT ANXA1 ANXA1 TEK TEK CD40 CD40 BMP4 BMP4 CIB1 CIB1 ANXA3 ANXA3 ITGB3 ITGB3 GPI GPI PROX1 PROX1 PIK3CG PIK3CG AKT3 AKT3 KDR KDR HSPB1 HSPB1 FGF1 FGF1 PDCD6 PDCD6 ADGRA2 ADGRA2 ATP5F1B ATP5F1B P2RX4 P2RX4 ITGB1BP1 ITGB1BP1 PIK3CB PIK3CB PRKD2 PRKD2 NOS3 NOS3 BMPR2 BMPR2 FLT4 FLT4 PTK2B PTK2B GATA3 GATA3 PDGFB PDGFB ZNF580 ZNF580 RRAS RRAS PRKD1 PRKD1 FGF18 FGF18 PLPP3 PLPP3 RIN2 RIN2 FGF16 FGF16 ATOH8 ATOH8 SIRT1 SIRT1 ABL1 ABL1 FOXP1 FOXP1 MAP2K3 MAP2K3 AKT1 AKT1 HDAC7 HDAC7 ETS1 ETS1 NRP1 NRP1 PRKCA PRKCA SMOC2 SMOC2 SP1 SP1 CCBE1 CCBE1 LOC100068923 LOC100068923 GPLD1 GPLD1 STAT5A STAT5A EMC10 EMC10 PDPK1 PDPK1 SASH1 SASH1 HIF1A HIF1A BCAR1 BCAR1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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ATP5F1AATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (553 aa)
HMOX1Heme oxygenase 1. (490 aa)
RHOJRas homolog family member J. (236 aa)
LOC100054259L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (346 aa)
LOC100054308L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (346 aa)
FUT1L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (370 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
HMGB1High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...] (215 aa)
AKT2Non-specific serine/threonine protein kinase. (528 aa)
MAP3K3Mitogen-activated protein kinase kinase kinase 3. (657 aa)
THBS1Thrombospondin 1. (1170 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (615 aa)
ANGPT4Angiopoietin 4. (497 aa)
VEGFAVascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (448 aa)
LGMNLegumain. (433 aa)
NUS1NUS1 dehydrodolichyl diphosphate synthase subunit. (293 aa)
METHepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...] (1412 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
AAMPAngio associated migratory cell protein. (435 aa)
LOC100062428Calreticulin. (408 aa)
AGTAngiotensinogen; Belongs to the serpin family. (483 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (346 aa)
TEKTEK receptor tyrosine kinase. (1153 aa)
CD40Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). (280 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
CIB1Calcium and integrin binding 1. (191 aa)
ANXA3Annexin. (323 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (573 aa)
PROX1Prospero homeobox 1. (737 aa)
PIK3CGPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1358 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (209 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
PDCD6Programmed cell death 6. (189 aa)
ADGRA2Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1338 aa)
ATP5F1BATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. (528 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (388 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1267 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1366 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1081 aa)
GATA3GATA binding protein 3. (445 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (249 aa)
ZNF580Zinc finger protein 580. (172 aa)
RRASRAS related. (220 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
PLPP3Phospholipid phosphatase 3. (312 aa)
RIN2Ras and Rab interactor 2. (980 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ATOH8Atonal bHLH transcription factor 8. (388 aa)
SIRT1Sirtuin 1. (737 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
FOXP1Forkhead box P1. (691 aa)
MAP2K3Mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
HDAC7Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (990 aa)
ETS1ETS proto-oncogene 1, transcription factor. (503 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
SMOC2SPARC related modular calcium binding 2. (646 aa)
SP1Sp1 transcription factor. (787 aa)
CCBE1Collagen and calcium binding EGF domains 1. (439 aa)
LOC100068923Uncharacterized protein. (212 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (867 aa)
STAT5ASignal transducer and activator of transcription. (800 aa)
EMC10ER membrane protein complex subunit 10. (597 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (585 aa)
SASH1SAM and SH3 domain containing 1. (1234 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (844 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (887 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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