STRINGSTRING
BMP10 BMP10 ATP2B4 ATP2B4 TNF TNF THBS1 THBS1 FGF2 FGF2 DLL4 DLL4 HRG HRG SYNJ2BP SYNJ2BP ANGPT2 ANGPT2 MMRN2 MMRN2 PDCD10 PDCD10 SVBP SVBP DCN DCN CSNK2B CSNK2B HDAC5 HDAC5 APOH APOH NOTCH1 NOTCH1 DNAJA4 DNAJA4 ITGB1BP1 ITGB1BP1 DAB2IP DAB2IP GADD45A GADD45A GDF2 GDF2 MEF2C MEF2C PATZ1 PATZ1 ACVRL1 ACVRL1 KRIT1 KRIT1 SPRED1 SPRED1 CARD10 CARD10 STARD13 STARD13 ENSECAP00000041998 ENSECAP00000041998 SLIT2 SLIT2 VASH1 VASH1 TBXA2R TBXA2R MECP2 MECP2 JUP JUP CXCL13 CXCL13 TGFB1 TGFB1 MEOX2 MEOX2 ANGPT4 ANGPT4 HMGB1 HMGB1 LY6G5B LY6G5B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMP10Bone morphogenetic protein 10. (424 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1206 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa)
THBS1Thrombospondin 1. (1170 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
HRGHistidine rich glycoprotein. (483 aa)
SYNJ2BPPDZ domain-containing protein. (145 aa)
ANGPT2Angiopoietin 2. (496 aa)
MMRN2Multimerin 2. (916 aa)
PDCD10Programmed cell death 10. (212 aa)
SVBPSmall vasohibin binding protein. (66 aa)
DCNDecorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (360 aa)
CSNK2BCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (235 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1117 aa)
APOHApolipoprotein H. (345 aa)
NOTCH1Notch receptor 1. (2581 aa)
DNAJA4DnaJ heat shock protein family (Hsp40) member A4. (519 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
DAB2IPDAB2 interacting protein. (1166 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
GDF2Growth differentiation factor 2. (427 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
PATZ1POZ/BTB and AT hook containing zinc finger 1. (687 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (517 aa)
KRIT1KRIT1 ankyrin repeat containing. (727 aa)
SPRED1Sprouty related EVH1 domain containing 1. (442 aa)
CARD10Caspase recruitment domain family member 10. (1141 aa)
STARD13StAR related lipid transfer domain containing 13. (1144 aa)
ENSECAP00000041998Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (117 aa)
SLIT2Slit guidance ligand 2. (1543 aa)
VASH1Vasohibin 1. (414 aa)
TBXA2RThromboxane A2 receptor; Belongs to the G-protein coupled receptor 1 family. (343 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
JUPJunction plakoglobin. (960 aa)
CXCL13C-X-C motif chemokine. (110 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
MEOX2Mesenchyme homeobox 2. (303 aa)
ANGPT4Angiopoietin 4. (497 aa)
HMGB1High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...] (215 aa)
LY6G5BLymphocyte antigen 6 family member G5B. (202 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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