STRINGSTRING
TGFB1 TGFB1 F2R F2R UCN UCN SERPINF2 SERPINF2 F2 F2 IL6 IL6 BMP4 BMP4 VSIR VSIR EMILIN1 EMILIN1 LARP6 LARP6 CREB3L1 CREB3L1 TGFB3 TGFB3 MFAP4 MFAP4 SUCO SUCO ITGB1 ITGB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (428 aa)
UCNUrocortin. (126 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (491 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (231 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
VSIRV-set immunoregulatory receptor. (311 aa)
EMILIN1Elastin microfibril interfacer 1. (1016 aa)
LARP6La ribonucleoprotein domain family member 6. (492 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (524 aa)
TGFB3Transforming growth factor beta 3. (490 aa)
MFAP4Microfibril associated protein 4. (271 aa)
SUCOSUN domain containing ossification factor. (1257 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (808 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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