(30 nodes) Regulation of peptidyl-threonine phosphorylation network (Equus caballus)

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Your Input:
	SPRY2	Sprouty RTK signaling antagonist 2. (315 aa)
	SPHK1	Sphingosine kinase 1. (459 aa)
	AZU1	Azurocidin 1. (251 aa)
	CHI3L1	Chitinase 3 like 1; Belongs to the glycosyl hydrolase 18 family. (427 aa)
	SPRED2	Sprouty related EVH1 domain containing 2. (417 aa)
	SPRED1	Sprouty related EVH1 domain containing 1. (442 aa)
	CEMIP	Cell migration inducing hyaluronidase 1. (1489 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (569 aa)
	SIRT2	Sirtuin 2. (462 aa)
	STOX1	Storkhead box 1. (1084 aa)
	RPTOR	Regulatory associated protein of MTOR complex 1. (1384 aa)
	WNK3	WNK lysine deficient protein kinase 3. (1801 aa)
	AXIN1	Axin 1. (939 aa)
	TTC36	Tetratricopeptide repeat domain 36. (188 aa)
	TGFB1	Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
	PRKAG2	Protein kinase AMP-activated non-catalytic subunit gamma 2. (564 aa)
	CADM4	Cell adhesion molecule 4. (388 aa)
	UBE2K	Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (200 aa)
	CAB39	Calcium binding protein 39. (373 aa)
	INPP5K	Inositol polyphosphate-5-phosphatase K. (449 aa)
	PLK1	Serine/threonine-protein kinase PLK. (604 aa)
	GSK3A	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (483 aa)
	SMAD7	Mothers against decapentaplegic homolog. (426 aa)
	APP	Amyloid beta precursor protein. (811 aa)
	DGKQ	Diacylglycerol kinase. (931 aa)
	S1PR2	Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (351 aa)
	DDIT4	DNA damage inducible transcript 4. (231 aa)
	SSRP1	HMG box domain-containing protein. (2401 aa)
	DMTN	Dematin actin binding protein. (405 aa)
	MAPK1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (594 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APP	TGFB1	ENSECAP00000019519	ENSECAP00000009480	Amyloid beta precursor protein.	Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...]	0.466
AXIN1	GSK3A	ENSECAP00000021226	ENSECAP00000017279	Axin 1.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.938
AXIN1	SMAD7	ENSECAP00000021226	ENSECAP00000018077	Axin 1.	Mothers against decapentaplegic homolog.	0.451
CAB39	PRKAG2	ENSECAP00000013085	ENSECAP00000010764	Calcium binding protein 39.	Protein kinase AMP-activated non-catalytic subunit gamma 2.	0.844
DGKQ	INPP5K	ENSECAP00000019923	ENSECAP00000014405	Diacylglycerol kinase.	Inositol polyphosphate-5-phosphatase K.	0.576
GSK3A	AXIN1	ENSECAP00000017279	ENSECAP00000021226	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Axin 1.	0.938
INPP5K	DGKQ	ENSECAP00000014405	ENSECAP00000019923	Inositol polyphosphate-5-phosphatase K.	Diacylglycerol kinase.	0.576
MAPK1	SPHK1	ENSECAP00000048276	ENSECAP00000043398	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Sphingosine kinase 1.	0.908
PRKAG2	CAB39	ENSECAP00000010764	ENSECAP00000013085	Protein kinase AMP-activated non-catalytic subunit gamma 2.	Calcium binding protein 39.	0.844
PRKAG2	RPTOR	ENSECAP00000010764	ENSECAP00000024465	Protein kinase AMP-activated non-catalytic subunit gamma 2.	Regulatory associated protein of MTOR complex 1.	0.952
RPTOR	PRKAG2	ENSECAP00000024465	ENSECAP00000010764	Regulatory associated protein of MTOR complex 1.	Protein kinase AMP-activated non-catalytic subunit gamma 2.	0.952
S1PR2	SPHK1	ENSECAP00000003187	ENSECAP00000043398	Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family.	Sphingosine kinase 1.	0.723
SMAD7	AXIN1	ENSECAP00000018077	ENSECAP00000021226	Mothers against decapentaplegic homolog.	Axin 1.	0.451
SMAD7	TGFB1	ENSECAP00000018077	ENSECAP00000009480	Mothers against decapentaplegic homolog.	Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...]	0.936
SPHK1	MAPK1	ENSECAP00000043398	ENSECAP00000048276	Sphingosine kinase 1.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.908
SPHK1	S1PR2	ENSECAP00000043398	ENSECAP00000003187	Sphingosine kinase 1.	Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family.	0.723
SPRED1	SPRED2	ENSECAP00000037687	ENSECAP00000038149	Sprouty related EVH1 domain containing 1.	Sprouty related EVH1 domain containing 2.	0.890
SPRED2	SPRED1	ENSECAP00000038149	ENSECAP00000037687	Sprouty related EVH1 domain containing 2.	Sprouty related EVH1 domain containing 1.	0.890
TGFB1	APP	ENSECAP00000009480	ENSECAP00000019519	Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...]	Amyloid beta precursor protein.	0.466
TGFB1	SMAD7	ENSECAP00000009480	ENSECAP00000018077	Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...]	Mothers against decapentaplegic homolog.	0.936