STRINGSTRING
CDH13 CDH13 JUP JUP LRRC45 LRRC45 COL26A1 COL26A1 VIT VIT MACF1 MACF1 LOC111767399 LOC111767399 DMTN DMTN GPM6B GPM6B LIMS1 LIMS1 EFEMP2 EFEMP2 EMID1 EMID1 CORO1C CORO1C CDK6 CDK6 CASS4 CASS4 CAMSAP3 CAMSAP3 UNC13D UNC13D NEDD9 NEDD9 FZD4 FZD4 LOC111771846 LOC111771846 LOC111775907 LOC111775907 EMP2 EMP2 ACTN4 ACTN4 KANK1 KANK1 FZD7 FZD7 PDPN PDPN DISC1 DISC1 SKAP1 SKAP1 PHLDB2 PHLDB2 PLET1 PLET1 ARHGAP6 ARHGAP6 PTPRA PTPRA BST1 BST1 RAC2 RAC2 NRP1 NRP1 ABI3BP ABI3BP RREB1 RREB1 SLK SLK ENSECAP00000033804 ENSECAP00000033804 ADAM15 ADAM15 ACVRL1 ACVRL1 ENSECAP00000032092 ENSECAP00000032092 ABL1 ABL1 EGFLAM EGFLAM LIMS2 LIMS2 STK4 STK4 PTPRJ PTPRJ ILK ILK RIN2 RIN2 BRAF BRAF NEXMIF NEXMIF CRKL CRKL LIMCH1 LIMCH1 WDPCP WDPCP RRAS RRAS CDC42 CDC42 FBLN1 FBLN1 RCC2 RCC2 ENSECAP00000023954 ENSECAP00000023954 ENSECAP00000023457 ENSECAP00000023457 PTK2B PTK2B DDR1 DDR1 EMILIN1 EMILIN1 CCN1 CCN1 GSK3B GSK3B CARMIL1 CARMIL1 COL16A1 COL16A1 PIK3CB PIK3CB EPHA1 EPHA1 ITGB1BP1 ITGB1BP1 NOTCH1 NOTCH1 APOD APOD ROCK1 ROCK1 SFRP1 SFRP1 FERMT2 FERMT2 AJAP1 AJAP1 PIK3R1 PIK3R1 KDR KDR MYF5 MYF5 RELL2 RELL2 FOXF1 FOXF1 CCDC80 CCDC80 ECM2 ECM2 COL8A1 COL8A1 S100A10 S100A10 ITGB3 ITGB3 LOC100058594 LOC100058594 LOC100060619 LOC100060619 CIB1 CIB1 CORO2A CORO2A ARL2 ARL2 CSF1 CSF1 RSU1 RSU1 TEK TEK ACER2 ACER2 NID1 NID1 PPM1F PPM1F ANGPT2 ANGPT2 VTN VTN EDIL3 EDIL3 VWC2 VWC2 LOC100062428 LOC100062428 PREX1 PREX1 CASK CASK CORO2B CORO2B LOC100063059 LOC100063059 VCL VCL JAG1 JAG1 PLEKHA2 PLEKHA2 HRG HRG LDB1 LDB1 EFNA5 EFNA5 C1QBP C1QBP FLNA FLNA CRK CRK ONECUT2 ONECUT2 AGR2 AGR2 MELTF MELTF TBCD TBCD HSD17B12 HSD17B12 MYOC MYOC TSC1 TSC1 P4HB P4HB THY1 THY1 VEGFA VEGFA NF1 NF1 THBS1 THBS1 SPOCK2 SPOCK2 FBLN2 FBLN2 EGFL6 EGFL6 WNT1 WNT1 CCL28 CCL28 PLAU PLAU AP1AR AP1AR SPOCK1 SPOCK1 SEMA3E SEMA3E FN1 FN1 RASA1 RASA1 FUT1 FUT1 LOC100054308 LOC100054308 LOC100054259 LOC100054259 HOXA7 HOXA7 BCL6 BCL6 SPRY4 SPRY4 TACSTD2 TACSTD2 F6SXQ9_HORSE F6SXQ9_HORSE PRKCE PRKCE GREM1 GREM1 MYADM MYADM FERMT1 FERMT1 TESK1 TESK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CDH13Cadherin 13. (712 aa)
JUPJunction plakoglobin. (960 aa)
LRRC45Leucine rich repeat containing 45. (695 aa)
COL26A1Collagen type XXVI alpha 1 chain. (570 aa)
VITVitrin. (694 aa)
MACF1Microtubule actin crosslinking factor 1. (7655 aa)
LOC111767399TRIO and F-actin binding protein. (684 aa)
DMTNDematin actin binding protein. (405 aa)
GPM6BGlycoprotein M6B. (328 aa)
LIMS1LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (398 aa)
EFEMP2EGF containing fibulin extracellular matrix protein 2. (517 aa)
EMID1EMI domain containing 1. (444 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (525 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (403 aa)
CASS4Cas scaffold protein family member 4. (975 aa)
CAMSAP3Calmodulin regulated spectrin associated protein family member 3. (1269 aa)
UNC13DUnc-13 homolog D. (1137 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (834 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
LOC111771846Receptor-type tyrosine-protein phosphatase eta-like. (1211 aa)
LOC111775907Uncharacterized protein. (1211 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (205 aa)
ACTN4Actinin alpha 4. (933 aa)
KANK1KN motif and ankyrin repeat domains 1. (1433 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
PDPNUncharacterized protein. (152 aa)
DISC1DISC1 scaffold protein. (890 aa)
SKAP1Src kinase associated phosphoprotein 1. (464 aa)
PHLDB2Pleckstrin homology like domain family B member 2. (1340 aa)
PLET1Uncharacterized protein. (249 aa)
ARHGAP6Rho GTPase activating protein 6. (853 aa)
PTPRAReceptor-type tyrosine-protein phosphatase alpha. (813 aa)
BST1Bone marrow stromal cell antigen 1. (383 aa)
RAC2Rac family small GTPase 2. (192 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
ABI3BPABI family member 3 binding protein. (1777 aa)
RREB1Ras responsive element binding protein 1. (1773 aa)
SLKSTE20 like kinase. (1266 aa)
ENSECAP00000033804Uncharacterized protein. (1210 aa)
ADAM15ADAM metallopeptidase domain 15. (970 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (517 aa)
ENSECAP00000032092Uncharacterized protein. (545 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
EGFLAMEGF like, fibronectin type III and laminin G domains. (1017 aa)
LIMS2LIM zinc finger domain containing 2. (476 aa)
STK4Serine/threonine kinase 4. (493 aa)
PTPRJUncharacterized protein. (1267 aa)
ILKIntegrin linked kinase. (452 aa)
RIN2Ras and Rab interactor 2. (980 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (793 aa)
NEXMIFNeurite extension and migration factor. (1515 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
LIMCH1LIM and calponin homology domains 1. (1624 aa)
WDPCPWD repeat containing planar cell polarity effector. (714 aa)
RRASRAS related. (220 aa)
CDC42Cell division control protein 42-like protein. (191 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (753 aa)
RCC2Regulator of chromosome condensation 2. (561 aa)
ENSECAP00000023954PH domain-containing protein. (649 aa)
ENSECAP00000023457Uncharacterized protein. (189 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1081 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (985 aa)
EMILIN1Elastin microfibril interfacer 1. (1016 aa)
CCN1Cellular communication network factor 1. (382 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (440 aa)
CARMIL1Capping protein regulator and myosin 1 linker 1. (1432 aa)
COL16A1Collagen type XVI alpha 1 chain. (1612 aa)
PIK3CBPhosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
EPHA1EPH receptor A1. (976 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
NOTCH1Notch receptor 1. (2581 aa)
APODApolipoprotein D. (213 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
FERMT2Fermitin family member 2. (707 aa)
AJAP1Adherens junctions associated protein 1. (409 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1358 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
RELL2RELT like 2. (302 aa)
FOXF1Forkhead box F1. (431 aa)
CCDC80Coiled-coil domain containing 80. (955 aa)
ECM2Extracellular matrix protein 2. (698 aa)
COL8A1Collagen type VIII alpha 1 chain. (735 aa)
S100A10S100 calcium binding protein A10; Belongs to the S-100 family. (97 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
LOC100058594Uncharacterized protein. (629 aa)
LOC100060619SCY domain-containing protein. (124 aa)
CIB1Calcium and integrin binding 1. (191 aa)
CORO2ACoronin; Belongs to the WD repeat coronin family. (531 aa)
ARL2ARL2-SNX15 readthrough (NMD candidate); Belongs to the small GTPase superfamily. Arf family. (184 aa)
CSF1Colony stimulating factor 1. (630 aa)
RSU1Ras suppressor protein 1. (296 aa)
TEKTEK receptor tyrosine kinase. (1153 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (274 aa)
NID1Nidogen 1. (1244 aa)
PPM1FProtein phosphatase, Mg2+/Mn2+ dependent 1F. (448 aa)
ANGPT2Angiopoietin 2. (496 aa)
VTNVitronectin. (478 aa)
EDIL3EGF like repeats and discoidin domains 3. (481 aa)
VWC2Von Willebrand factor C domain containing 2. (325 aa)
LOC100062428Calreticulin. (408 aa)
PREX1Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1757 aa)
CASKCalcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family. (926 aa)
CORO2BCoronin; Belongs to the WD repeat coronin family. (480 aa)
LOC100063059SCY domain-containing protein. (131 aa)
VCLVinculin. (1284 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
PLEKHA2Pleckstrin homology domain containing A2. (425 aa)
HRGHistidine rich glycoprotein. (483 aa)
LDB1LIM domain binding 1. (411 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
C1QBPComplement C1q binding protein. (279 aa)
FLNAFilamin A. (2647 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
ONECUT2One cut domain family member. (505 aa)
AGR2Anterior gradient 2, protein disulphide isomerase family member. (175 aa)
MELTFMelanotransferrin; Belongs to the transferrin family. (739 aa)
TBCDTubulin folding cofactor D. (1193 aa)
HSD17B12Hydroxysteroid 17-beta dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (312 aa)
MYOCMyocilin. (490 aa)
TSC1TSC complex subunit 1. (1232 aa)
P4HBProtein disulfide-isomerase. (510 aa)
THY1Thy-1 cell surface antigen. (161 aa)
VEGFAVascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (448 aa)
NF1Neurofibromin 1. (3024 aa)
THBS1Thrombospondin 1. (1170 aa)
SPOCK2SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2. (424 aa)
FBLN2Fibulin 2. (1230 aa)
EGFL6EGF like domain multiple 6. (642 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
CCL28C-C motif chemokine. (129 aa)
PLAUPlasminogen activator, urokinase. (433 aa)
AP1ARAdaptor related protein complex 1 associated regulatory protein. (302 aa)
SPOCK1SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1. (515 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (776 aa)
FN1Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). (2477 aa)
RASA1RAS p21 protein activator 1. (1041 aa)
FUT1L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (370 aa)
LOC100054308L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (346 aa)
LOC100054259L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (346 aa)
HOXA7Homeobox A7. (234 aa)
BCL6BCL6 transcription repressor. (699 aa)
SPRY4Sprouty RTK signaling antagonist 4. (321 aa)
TACSTD2Tumor associated calcium signal transducer 2. (333 aa)
F6SXQ9_HORSEUncharacterized protein. (191 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (143 aa)
MYADMMyeloid associated differentiation marker. (322 aa)
FERMT1Fermitin family member 1. (677 aa)
TESK1Testis associated actin remodelling kinase 1. (628 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
Server load: low (26%) [HD]