STRINGSTRING
BOK BOK HTRA2 HTRA2 LAPTM5 LAPTM5 GPER1 GPER1 NKX3-1 NKX3-1 TNF TNF AIFM1 AIFM1 F2R F2R EGLN3 EGLN3 CASP8 CASP8 PML PML BID BID MEFV MEFV TTBK1 TTBK1 PSENEN PSENEN HMGB1 HMGB1 NLRP1 NLRP1 PYCARD PYCARD P2RX1 P2RX1 S100A8 S100A8 CIDEB CIDEB LGMN LGMN IFT57 IFT57 MALT1 MALT1 FAS FAS RPS3 RPS3 EPHA4 EPHA4 CYCS CYCS BAD BAD NLRP3 NLRP3 MUL1 MUL1 PPM1F PPM1F UACA UACA FASLG FASLG BAX BAX PDCD2 PDCD2 NODAL NODAL SFRP2 SFRP2 ACER2 ACER2 PRR7 PRR7 NLRP12 NLRP12 NGFR NGFR NDUFA13 NDUFA13 VSIR VSIR YJEFN3 YJEFN3 PSME2 PSME2 TBC1D10A TBC1D10A PDCD5 PDCD5 CARD9 CARD9 NLRC4 NLRC4 ACVR1C ACVR1C DIABLO DIABLO FAM162A FAM162A AGER AGER PDCD6 PDCD6 EFNA1 EFNA1 FADD FADD CFLAR CFLAR MYC MYC TFAP4 TFAP4 RACK1 RACK1 REST REST PRELID1 PRELID1 F3 F3 USP50 USP50 BAK1 BAK1 CASP10 CASP10 CCN1 CCN1 BCL10 BCL10 MTCH1 MTCH1 TNFSF15 TNFSF15 BBC3 BBC3 LOC102148739 LOC102148739 FOXL2 FOXL2 S100A9 S100A9 ATP2A3 ATP2A3 GSN GSN NLRP6 NLRP6 PSME3 PSME3 LOC100061598 LOC100061598 FIS1 FIS1 DAP DAP SIRT1 SIRT1 CASP2 CASP2 APH1A APH1A PIDD1 PIDD1 RIPK2 RIPK2 SENP1 SENP1 ENSECAP00000033783 ENSECAP00000033783 CYFIP2 CYFIP2 NEK5 NEK5 EFNA3 EFNA3 CTSH CTSH STAT3 STAT3 DDX3X DDX3X SYK SYK AIM2 AIM2 MAP3K5 MAP3K5 CASP9 CASP9 CASP8AP2 CASP8AP2 SMAD3 SMAD3 ASPH ASPH CRADD CRADD PMAIP1 PMAIP1 NCSTN NCSTN LYN LYN NOD1 NOD1 RP1L1 RP1L1 HIP1 HIP1 PAWR PAWR LOC100061631 LOC100061631 PSME1 PSME1 BCAP31 BCAP31 LOC111775628 LOC111775628 ENSECAP00000051121 ENSECAP00000051121 APH1B APH1B DAPK1 DAPK1 BCL2L11 BCL2L11 GRAMD4 GRAMD4 HIP1R HIP1R
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BOKBCL2 family apoptosis regulator BOK. (213 aa)
HTRA2HtrA serine peptidase 2. (458 aa)
LAPTM5Lysosomal protein transmembrane 5. (288 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
NKX3-1NK3 homeobox 1. (240 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa)
AIFM1Apoptosis inducing factor mitochondria associated 1. (613 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (428 aa)
EGLN3Egl-9 family hypoxia inducible factor 3. (239 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (464 aa)
PMLPromyelocytic leukemia. (881 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (194 aa)
MEFVMEFV innate immuity regulator, pyrin. (117 aa)
TTBK1Tau tubulin kinase 1. (1409 aa)
PSENENPresenilin enhancer, gamma-secretase subunit. (101 aa)
HMGB1High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...] (215 aa)
NLRP1NLR family pyrin domain containing 1. (1448 aa)
PYCARDPYD and CARD domain containing. (195 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
S100A8Protein S100; Belongs to the S-100 family. (89 aa)
CIDEBCell death inducing DFFA like effector b. (222 aa)
LGMNLegumain. (433 aa)
IFT57Intraflagellar transport 57. (429 aa)
MALT1MALT1 paracaspase. (850 aa)
FASFas cell surface death receptor. (365 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (281 aa)
EPHA4EPH receptor A4. (949 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
BADBCL2 associated agonist of cell death. (167 aa)
NLRP3NLR family pyrin domain containing 3. (1031 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (422 aa)
PPM1FProtein phosphatase, Mg2+/Mn2+ dependent 1F. (448 aa)
UACAUveal autoantigen with coiled-coil domains and ankyrin repeats. (1416 aa)
FASLGTumor necrosis factor ligand 1A; Belongs to the tumor necrosis factor family. (283 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
PDCD2Programmed cell death 2. (344 aa)
NODALNodal growth differentiation factor. (348 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (274 aa)
PRR7Proline rich 7, synaptic. (274 aa)
NLRP12NLR family pyrin domain containing 12. (1061 aa)
NGFRNerve growth factor receptor. (435 aa)
NDUFA13NADH:ubiquinone oxidoreductase subunit A13. (144 aa)
VSIRV-set immunoregulatory receptor. (311 aa)
YJEFN3YjeF N-terminal domain-containing protein. (249 aa)
PSME2Proteasome activator subunit 2. (239 aa)
TBC1D10ATBC1 domain family member 10A. (509 aa)
PDCD5Programmed cell death 5. (125 aa)
CARD9Caspase recruitment domain family member 9. (537 aa)
NLRC4NLR family CARD domain containing 4. (1053 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (492 aa)
DIABLODiablo IAP-binding mitochondrial protein. (237 aa)
FAM162AFamily with sequence similarity 162 member A. (155 aa)
AGERAdvanced glycosylation end-product specific receptor. (403 aa)
PDCD6Programmed cell death 6. (189 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (317 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (212 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (510 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (442 aa)
TFAP4Transcription factor AP-4. (338 aa)
RACK1WD_REPEATS_REGION domain-containing protein. (317 aa)
RESTRE1 silencing transcription factor. (1039 aa)
PRELID1PRELI domain containing 1. (219 aa)
F3Coagulation factor III, tissue factor. (388 aa)
USP50Ubiquitin specific peptidase 50; Belongs to the peptidase C19 family. (333 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (478 aa)
CCN1Cellular communication network factor 1. (382 aa)
BCL10BCL10 immune signaling adaptor. (374 aa)
MTCH1Mitochondrial carrier 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (435 aa)
TNFSF15Tumor necrosis factor ligand 1B. (260 aa)
BBC3BCL2 binding component 3. (261 aa)
LOC102148739NACHT domain-containing protein. (1069 aa)
FOXL2Forkhead box L2. (378 aa)
S100A9EF-hand domain-containing protein; Belongs to the S-100 family. (153 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1098 aa)
GSNGelsolin; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis (By similarity). (871 aa)
NLRP6NLR family pyrin domain containing 6. (892 aa)
PSME3Proteasome activator subunit 3. (265 aa)
LOC100061598EF-hand domain-containing protein; Belongs to the S-100 family. (162 aa)
FIS1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
DAPUncharacterized protein. (250 aa)
SIRT1Sirtuin 1. (737 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (452 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (274 aa)
PIDD1P53-induced death domain protein 1. (915 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (569 aa)
SENP1SUMO specific peptidase 1. (691 aa)
ENSECAP00000033783Uncharacterized protein. (78 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
NEK5NIMA related kinase 5. (812 aa)
EFNA3Ephrin RBD domain-containing protein; Belongs to the ephrin family. (436 aa)
CTSHUncharacterized protein; Belongs to the peptidase C1 family. (386 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (685 aa)
SYKTyrosine-protein kinase. (716 aa)
AIM2Absent in melanoma 2. (352 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1362 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (632 aa)
CASP8AP2Caspase 8 associated protein 2. (2070 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
ASPHAspartate beta-hydroxylase. (790 aa)
CRADDCASP2 and RIPK1 domain containing adaptor with death domain. (233 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
NCSTNNicastrin. (709 aa)
LYNTyrosine-protein kinase. (533 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (993 aa)
RP1L1Uncharacterized protein. (387 aa)
HIP1Huntingtin interacting protein 1. (1082 aa)
PAWRUncharacterized protein. (596 aa)
LOC100061631EF-hand domain-containing protein; Belongs to the S-100 family. (160 aa)
PSME1Proteasome activator subunit 1. (249 aa)
BCAP31B cell receptor associated protein 31. (280 aa)
LOC111775628Uncharacterized protein; Belongs to the peptidase C1 family. (428 aa)
ENSECAP00000051121KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
APH1BAph-1 homolog B, gamma-secretase subunit. (524 aa)
DAPK1Death associated protein kinase 1. (1457 aa)
BCL2L11BCL2 like 11. (289 aa)
GRAMD4GRAM domain containing 4. (728 aa)
HIP1RHuntingtin interacting protein 1 related. (1203 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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