STRINGSTRING
TNF TNF NF1 NF1 CLCF1 CLCF1 GFAP GFAP PLAG1 PLAG1 EGR2 EGR2 TGFB1 TGFB1 F2 F2 IL34 IL34 RNF112 RNF112 GSX2 GSX2 PRKCH PRKCH TREM2 TREM2 SERPINE2 SERPINE2 IL6 IL6 NR2E1 NR2E1 GPR37L1 GPR37L1 KRAS KRAS BMP2 BMP2 ASPA ASPA NKX6-1 NKX6-1 EZH2 EZH2 NOTCH1 NOTCH1 SOX10 SOX10 DLX1 DLX1 NTN1 NTN1 HES1 HES1 BIN1 BIN1 HES5 HES5 IL6ST IL6ST PRKCI PRKCI LOC111771777 LOC111771777 PTN PTN LIF LIF TENM4 TENM4 UFL1 UFL1 NF2 NF2 TP53 TP53 VEGFC VEGFC ENSECAP00000039029 ENSECAP00000039029 RB1 RB1 LRP2 LRP2 NKX6-2 NKX6-2 SOX11 SOX11 LOC111767415 LOC111767415 SERPINE2-2 SERPINE2-2 OLIG2 OLIG2 SOX8 SOX8 MECP2 MECP2 TMEM98 TMEM98 MTOR MTOR ZNF365 ZNF365 TNFRSF1B TNFRSF1B ZNF488 ZNF488 LDLR LDLR LOC100051785 LOC100051785 DLX2 DLX2 ATOH1 ATOH1 NR1D1 NR1D1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa)
NF1Neurofibromin 1. (3024 aa)
CLCF1Cardiotrophin like cytokine factor 1. (225 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (559 aa)
PLAG1PLAG1 zinc finger. (499 aa)
EGR2Early growth response 2. (486 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
IL34Interleukin 34. (242 aa)
RNF112Ring finger protein 112. (629 aa)
GSX2GS homeobox 2. (304 aa)
PRKCHProtein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (298 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (429 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (231 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
GPR37L1G protein-coupled receptor 37 like 1. (482 aa)
KRASKRAS proto-oncogene, GTPase. (189 aa)
BMP2Bone morphogenetic protein 2. (397 aa)
ASPAAspartoacylase. (324 aa)
NKX6-1NK6 homeobox 1. (366 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
NOTCH1Notch receptor 1. (2581 aa)
SOX10SRY-box transcription factor 10. (546 aa)
DLX1Distal-less homeobox 1. (255 aa)
NTN1Netrin 1. (604 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
BIN1Bridging integrator 1. (690 aa)
HES5Hes family bHLH transcription factor 5. (164 aa)
IL6STInterleukin 6 signal transducer. (1023 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (655 aa)
LOC111771777Glia-derived nexin. (429 aa)
PTNPleiotrophin. (192 aa)
LIFLIF interleukin 6 family cytokine. (203 aa)
TENM4Teneurin transmembrane protein 4. (2866 aa)
UFL1UFM1 specific ligase 1. (791 aa)
NF2Neurofibromin 2. (637 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (381 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (419 aa)
ENSECAP00000039029Uncharacterized protein. (188 aa)
RB1RB transcriptional corepressor 1. (965 aa)
LRP2LDL receptor related protein 2. (4673 aa)
NKX6-2NK6 homeobox 2. (277 aa)
SOX11Transcription factor SOX. (451 aa)
LOC111767415Glia-derived nexin. (397 aa)
SERPINE2-2Serpin family E member 2. (429 aa)
OLIG2Oligodendrocyte transcription factor 2. (323 aa)
SOX8SRY-box 8. (460 aa)
MECP2Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (498 aa)
TMEM98Transmembrane protein 98. (226 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2573 aa)
ZNF365Zinc finger protein 365. (406 aa)
TNFRSF1BTNF receptor superfamily member 1B. (481 aa)
ZNF488Zinc finger protein 488. (234 aa)
LDLRLow density lipoprotein receptor. (937 aa)
LOC100051785Uncharacterized protein. (188 aa)
DLX2Distal-less homeobox 2. (327 aa)
ATOH1Atonal bHLH transcription factor 1. (358 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (605 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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