35 items (Equus caballus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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co-expression

protein homology

Your Input:
	SERPINA12	Serpin family A member 12; Belongs to the serpin family. (443 aa)
	NYAP2	Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2. (798 aa)
	PIK3CD	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1044 aa)
	PRR5	Proline rich 5. (421 aa)
	PPARD	Peroxisome proliferator activated receptor delta. (441 aa)
	LOC100630841	Phosphatase tensin-type domain-containing protein. (294 aa)
	NF1	Neurofibromin 1. (3024 aa)
	CD160	CD160 molecule. (181 aa)
	EDN1	Endothelin 1. (202 aa)
	C1QBP	Complement C1q binding protein. (279 aa)
	RPS6KB1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
	PLEKHA1	Pleckstrin homology domain containing A1. (438 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	PTEN	Phosphatase and tensin homolog. (576 aa)
	PREX2	Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2. (1597 aa)
	ZFP36L1	ZFP36 ring finger protein like 1. (338 aa)
	HTR2B	5-hydroxytryptamine receptor 2B. (503 aa)
	PIK3CG	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1102 aa)
	PRR5L	Proline rich 5 like. (368 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	PEAR1	Platelet endothelial aggregation receptor 1. (1049 aa)
	PIK3C2G	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma; Belongs to the PI3/PI4-kinase family. (1486 aa)
	KBTBD2	Kelch repeat and BTB domain containing 2. (623 aa)
	PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1070 aa)
	ERBB3	Erb-b2 receptor tyrosine kinase 3. (1339 aa)
	PIK3R2	Uncharacterized protein. (479 aa)
	GATA3	GATA binding protein 3. (445 aa)
	MYO16	Myosin XVI; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (941 aa)
	SIRT2	Sirtuin 2. (462 aa)
	HTR2A	5-hydroxytryptamine receptor 2A. (470 aa)
	IGF1	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
	PIK3C2B	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; Belongs to the PI3/PI4-kinase family. (1850 aa)
	CD28	CD28 molecule. (228 aa)
	NYAP1	Neuronal tyrosine phosphorylated phosphoinositide-3-kinase adaptor 1. (964 aa)
	PIK3C2A	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha; Belongs to the PI3/PI4-kinase family. (1689 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD28	PIK3CA	ENSECAP00000047018	ENSECAP00000013092	CD28 molecule.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.941
CD28	PIK3CB	ENSECAP00000047018	ENSECAP00000021883	CD28 molecule.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.924
CD28	PIK3CD	ENSECAP00000047018	ENSECAP00000005743	CD28 molecule.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.933
CD28	PIK3R1	ENSECAP00000047018	ENSECAP00000017836	CD28 molecule.	Phosphoinositide-3-kinase regulatory subunit 1.	0.984
CD28	PIK3R2	ENSECAP00000047018	ENSECAP00000023307	CD28 molecule.	Uncharacterized protein.	0.962
EDN1	IGF1	ENSECAP00000009534	ENSECAP00000033255	Endothelin 1.	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.517
ERBB3	IGF1	ENSECAP00000022150	ENSECAP00000033255	Erb-b2 receptor tyrosine kinase 3.	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	0.758
ERBB3	PIK3CA	ENSECAP00000022150	ENSECAP00000013092	Erb-b2 receptor tyrosine kinase 3.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.978
ERBB3	PIK3CB	ENSECAP00000022150	ENSECAP00000021883	Erb-b2 receptor tyrosine kinase 3.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta; Belongs to the PI3/PI4-kinase family.	0.941
ERBB3	PIK3CD	ENSECAP00000022150	ENSECAP00000005743	Erb-b2 receptor tyrosine kinase 3.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.941
ERBB3	PIK3CG	ENSECAP00000022150	ENSECAP00000017454	Erb-b2 receptor tyrosine kinase 3.	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma; Belongs to the PI3/PI4-kinase family.	0.510
ERBB3	PIK3R1	ENSECAP00000022150	ENSECAP00000017836	Erb-b2 receptor tyrosine kinase 3.	Phosphoinositide-3-kinase regulatory subunit 1.	0.982
ERBB3	PIK3R2	ENSECAP00000022150	ENSECAP00000023307	Erb-b2 receptor tyrosine kinase 3.	Uncharacterized protein.	0.954
ERBB3	PTEN	ENSECAP00000022150	ENSECAP00000014788	Erb-b2 receptor tyrosine kinase 3.	Phosphatase and tensin homolog.	0.521
HTR2A	HTR2B	ENSECAP00000032673	ENSECAP00000016929	5-hydroxytryptamine receptor 2A.	5-hydroxytryptamine receptor 2B.	0.959
HTR2B	HTR2A	ENSECAP00000016929	ENSECAP00000032673	5-hydroxytryptamine receptor 2B.	5-hydroxytryptamine receptor 2A.	0.959
IGF1	EDN1	ENSECAP00000033255	ENSECAP00000009534	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	Endothelin 1.	0.517
IGF1	ERBB3	ENSECAP00000033255	ENSECAP00000022150	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	Erb-b2 receptor tyrosine kinase 3.	0.758
IGF1	PIK3CA	ENSECAP00000033255	ENSECAP00000013092	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.444
IGF1	PTEN	ENSECAP00000033255	ENSECAP00000014788	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...]	Phosphatase and tensin homolog.	0.701