STRINGSTRING
ENSECAP00000027804 ENSECAP00000027804 ENSECAP00000027234 ENSECAP00000027234 ENSECAP00000034428 ENSECAP00000034428 GLRX3 GLRX3 HSCB HSCB ENSECAP00000041588 ENSECAP00000041588 CIAPIN1 CIAPIN1 ISCA2 ISCA2 ENSECAP00000024743 ENSECAP00000024743 LYRM4 LYRM4 NFS1 NFS1 GLRX5 GLRX5 ISCU ISCU FXN FXN NUBP1 NUBP1 CIAO1 CIAO1 NFU1 NFU1 NUBP2 NUBP2 CIAO2B CIAO2B CIAO2A CIAO2A MMS19 MMS19 NARF NARF HSPA9 HSPA9 IBA57 IBA57 CIAO3 CIAO3 ABCB7 ABCB7 BOLA1 BOLA1 NUBPL NUBPL NDOR1 NDOR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSECAP00000027804NifU_N domain-containing protein. (205 aa)
ENSECAP00000027234Fe-S_biosyn domain-containing protein. (126 aa)
ENSECAP00000034428Uncharacterized protein. (97 aa)
GLRX3Glutaredoxin 3. (339 aa)
HSCBHscB mitochondrial iron-sulfur cluster cochaperone. (267 aa)
ENSECAP00000041588Uncharacterized protein. (152 aa)
CIAPIN1Anamorsin; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electron [...] (362 aa)
ISCA2Iron-sulfur cluster assembly 2. (154 aa)
ENSECAP00000024743Uncharacterized protein; Belongs to the BolA/IbaG family. (124 aa)
LYRM4LYR motif containing 4; Belongs to the complex I LYR family. (41 aa)
NFS1Aminotran_5 domain-containing protein. (457 aa)
GLRX5Glutaredoxin 5. (156 aa)
ISCUIron-sulfur cluster assembly enzyme; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. (167 aa)
FXNFrataxin. (211 aa)
NUBP1Cytosolic Fe-S cluster assembly factor NUBP1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily. (320 aa)
CIAO1Probable cytosolic iron-sulfur protein assembly protein CIAO1; Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation; Belongs to the WD repeat CIA1 family. (415 aa)
NFU1NFU1 iron-sulfur cluster scaffold. (253 aa)
NUBP2Cytosolic Fe-S cluster assembly factor NUBP2; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily. (271 aa)
CIAO2BCytosolic iron-sulfur assembly component 2B. (163 aa)
CIAO2ACytosolic iron-sulfur assembly component 2A. (160 aa)
MMS19MMS19 homolog, cytosolic iron-sulfur assembly component. (1030 aa)
NARFNuclear prelamin A recognition factor; Belongs to the NARF family. (456 aa)
HSPA9Heat shock protein family A (Hsp70) member 9; Belongs to the heat shock protein 70 family. (679 aa)
IBA57Iron-sulfur cluster assembly factor IBA57. (358 aa)
CIAO3Cytosolic iron-sulfur assembly component 3; Belongs to the NARF family. (476 aa)
ABCB7ATP binding cassette subfamily B member 7. (753 aa)
BOLA1BolA family member 1; Belongs to the BolA/IbaG family. (137 aa)
NUBPLNucleotide binding protein like. (370 aa)
NDOR1NADPH-dependent diflavin oxidoreductase 1; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Transfers electrons from NADPH to the Fe/S cluster of CIAPIN1. In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (597 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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