STRINGSTRING
TOPORS TOPORS KAT6A KAT6A TP53INP2 TP53INP2 BLM BLM ARNTL ARNTL MAPK7 MAPK7 NBN NBN MRE11 MRE11 LOC100049890 LOC100049890 HSF1 HSF1 TP73 TP73 LOC102148035 LOC102148035 PIAS2 PIAS2 ZMYM2 ZMYM2 F6SSM4_HORSE F6SSM4_HORSE PML PML CHEK2 CHEK2 CBX5 CBX5 HIPK2 HIPK2 KLHL20 KLHL20 TDP2 TDP2 TOP3A TOP3A TRIM8 TRIM8 PARK7 PARK7 TP53INP1 TP53INP1 RAD51 RAD51 SQSTM1 SQSTM1 DAXX DAXX SUMO3 SUMO3 SMC6 SMC6 GCNA GCNA RPA1 RPA1 N4BP1 N4BP1 RNF4 RNF4 ELF4 ELF4 EIF3E EIF3E NSMCE2 NSMCE2 TP63 TP63 ATRX ATRX IKBKE IKBKE SUMO2 SUMO2 CHFR CHFR ISG20 ISG20 LRCH4 LRCH4 TRIM16 TRIM16 HIPK3 HIPK3 SIRT1 SIRT1 THAP1 THAP1 TERT TERT TP53 TP53 TOPBP1 TOPBP1 SMC5 SMC5 PIAS1 PIAS1 PPARGC1A PPARGC1A HIPK1 HIPK1 CDK9 CDK9 WDFY3 WDFY3 CASP8AP2 CASP8AP2 ZBTB16 ZBTB16 RB1 RB1 RNF111 RNF111 NR2C1 NR2C1 BASP1 BASP1 MTOR MTOR CHD3 CHD3 SATB1 SATB1 RPAIN RPAIN CALCOCO2 CALCOCO2 MLIP MLIP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TOPORSTOP1 binding arginine/serine rich protein. (1045 aa)
KAT6AHistone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2009 aa)
TP53INP2Tumor protein p53 inducible nuclear protein 2. (221 aa)
BLMBLM RecQ like helicase. (1430 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator-like protein 1; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressur [...] (626 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (811 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (781 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
LOC100049890Small ubiquitin-related modifier. (95 aa)
HSF1Heat shock transcription factor 1. (535 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (655 aa)
LOC102148035Uncharacterized protein. (727 aa)
PIAS2Protein inhibitor of activated STAT 2. (621 aa)
ZMYM2Zinc finger MYM-type containing 2. (1391 aa)
F6SSM4_HORSEUbiquitin-like domain-containing protein. (52 aa)
PMLPromyelocytic leukemia. (881 aa)
CHEK2Checkpoint kinase 2. (544 aa)
CBX5Chromobox protein-like protein 5-like protein. (191 aa)
HIPK2Homeodomain interacting protein kinase 2. (1244 aa)
KLHL20Kelch like family member 20. (609 aa)
TDP2Tyrosyl-DNA phosphodiesterase 2. (362 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1032 aa)
TRIM8Tripartite motif containing 8. (551 aa)
PARK7Parkinsonism associated deglycase. (268 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (239 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
SQSTM1Sequestosome 1. (440 aa)
DAXXDeath domain associated protein. (748 aa)
SUMO3Small ubiquitin-related modifier. (104 aa)
SMC6Structural maintenance of chromosomes 6. (1101 aa)
GCNASprT-like domain-containing protein. (459 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
N4BP1NEDD4 binding protein 1. (897 aa)
RNF4Ring finger protein 4. (190 aa)
ELF4E74 like ETS transcription factor 4. (662 aa)
EIF3EEukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (445 aa)
NSMCE2NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (246 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
ATRXATRX chromatin remodeler. (2489 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (822 aa)
SUMO2Small ubiquitin like modifier 2. (95 aa)
CHFRCheckpoint with forkhead and ring finger domains. (708 aa)
ISG20Interferon stimulated exonuclease gene 20. (196 aa)
LRCH4Leucine rich repeats and calponin homology domain containing 4. (744 aa)
TRIM16Uncharacterized protein. (558 aa)
HIPK3Homeodomain interacting protein kinase 3. (1235 aa)
SIRT1Sirtuin 1. (737 aa)
THAP1THAP domain containing 1. (213 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1226 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (381 aa)
TOPBP1DNA topoisomerase II binding protein 1. (1515 aa)
SMC5Structural maintenance of chromosomes 5. (1103 aa)
PIAS1Protein inhibitor of activated STAT 1. (678 aa)
PPARGC1APPARG coactivator 1 alpha. (839 aa)
HIPK1Homeodomain interacting protein kinase 1. (1245 aa)
CDK9Cyclin dependent kinase 9; Belongs to the protein kinase superfamily. (494 aa)
WDFY3WD repeat and FYVE domain containing 3. (3609 aa)
CASP8AP2Caspase 8 associated protein 2. (2070 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
RB1RB transcriptional corepressor 1. (965 aa)
RNF111Ring finger protein 111. (720 aa)
NR2C1Nuclear receptor subfamily 2 group C member 1. (616 aa)
BASP1Uncharacterized protein. (343 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2573 aa)
CHD3Chromodomain helicase DNA binding protein 3. (2056 aa)
SATB1DNA-binding protein SATB. (790 aa)
RPAINRPA interacting protein. (229 aa)
CALCOCO2Calcium binding and coiled-coil domain 2. (502 aa)
MLIPMuscular LMNA interacting protein. (1008 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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