STRINGSTRING
MAST1 MAST1 PRKCE PRKCE LATS1 LATS1 GAS6 GAS6 PRKX PRKX CLSPN CLSPN AKT1 AKT1 PRKDC PRKDC MAPK9 MAPK9 ULK3 ULK3 PRKCQ PRKCQ NEK7 NEK7 HIPK1 HIPK1 PRKCA PRKCA PRKCZ PRKCZ CDK1 CDK1 VRK1 VRK1 PRKACA PRKACA MAST4 MAST4 NTRK2 NTRK2 STK4 STK4 IKBKB IKBKB GRK2 GRK2 HIPK3 HIPK3 ENSECAP00000029278 ENSECAP00000029278 ILK ILK LATS2 LATS2 CAMK1D CAMK1D MKNK2 MKNK2 LOC100054462 LOC100054462 NEK6 NEK6 PRKCI PRKCI PRKD1 PRKD1 PKN1 PKN1 ATM ATM RICTOR RICTOR RPS6KA1 RPS6KA1 IKBKE IKBKE SYK SYK CHUK CHUK EPO EPO ENSECAP00000037240 ENSECAP00000037240 TTK TTK CAMKV CAMKV TNKS TNKS MARK3 MARK3 MAPK13 MAPK13 ENSECAP00000041641 ENSECAP00000041641 TSSK6 TSSK6 PNCK PNCK PRKCB PRKCB PKD1 PKD1 CSNK1A1 CSNK1A1 MAP3K10 MAP3K10 MAPKAPK3 MAPKAPK3 PDPK1 PDPK1 STK32B STK32B CSNK2A1 CSNK2A1 DYRK1A DYRK1A PDGFB PDGFB STK32A STK32A STK38 STK38 STK39 STK39 MAST3 MAST3 PKN2 PKN2 GSK3B GSK3B PRKD2 PRKD2 CDK5 CDK5 RPS6KA5 RPS6KA5 TTBK2 TTBK2 BAK1 BAK1 STK38L STK38L CAMK1 CAMK1 PRKCD PRKCD CDC7 CDC7 PRKAA1 PRKAA1 DGKQ DGKQ MAPKAPK2 MAPKAPK2 LOC100055155 LOC100055155 AURKC AURKC ROCK1 ROCK1 TLK2 TLK2 HIPK4 HIPK4 VRK2 VRK2 TBK1 TBK1 PAK2 PAK2 DCLK3 DCLK3 AKT3 AKT3 GSK3A GSK3A PRKCG PRKCG SBK2 SBK2 RPS6KA4 RPS6KA4 PLK1 PLK1 MAPK12 MAPK12 ENSECAP00000014555 ENSECAP00000014555 ULK1 ULK1 CAMK4 CAMK4 TSSK4 TSSK4 DYRK2 DYRK2 CLK1 CLK1 CAB39 CAB39 PRPF4B PRPF4B CAMK1G CAMK1G AURKB AURKB RPS6KB1 RPS6KB1 CSNK2A2 CSNK2A2 PCK1 PCK1 PRKCH PRKCH SMG1 SMG1 MAPK7 MAPK7 PBK PBK PRKAA2 PRKAA2 MYO3A MYO3A RPS6KB2 RPS6KB2 RPS6KA3 RPS6KA3 KIAA1549 KIAA1549 ERN1 ERN1 MAP3K12 MAP3K12 LRRK2 LRRK2 NLK NLK RIPK1 RIPK1 CSNK1D CSNK1D MAPKAPK5 MAPKAPK5 SMTNL1 SMTNL1 MAST2 MAST2 STK32C STK32C MAP3K13 MAP3K13 HIPK2 HIPK2 PINK1 PINK1 AKT2 AKT2 LOC111774036 LOC111774036 SBK1 SBK1 TTBK1 TTBK1 CHEK2 CHEK2 DYRK1B DYRK1B CSNK1G1 CSNK1G1 MYO3B MYO3B AURKA AURKA MKNK1 MKNK1 TGFBR1 TGFBR1 PKN3 PKN3 DCLK1 DCLK1 SGK1 SGK1 ATR ATR MAPK1 MAPK1 RPS6KA6 RPS6KA6 CDK2 CDK2 DYRK3 DYRK3 MTOR MTOR DYRK4 DYRK4 TLK1 TLK1 MAP4K1 MAP4K1 RPS6KA2 RPS6KA2 VRK3 VRK3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAST1Microtubule associated serine/threonine kinase 1. (1571 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
LATS1Large tumor suppressor kinase 1. (1128 aa)
GAS6Growth arrest specific 6. (646 aa)
PRKXProtein kinase X-linked; Belongs to the protein kinase superfamily. (356 aa)
CLSPNClaspin. (1338 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (4166 aa)
MAPK9Mitogen-activated protein kinase. (446 aa)
ULK3Unc-51 like kinase 3; Belongs to the protein kinase superfamily. (496 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (811 aa)
NEK7NIMA related kinase 7; Belongs to the protein kinase superfamily. (432 aa)
HIPK1Homeodomain interacting protein kinase 1. (1245 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (591 aa)
CDK1Cyclin dependent kinase 1; Belongs to the protein kinase superfamily. (373 aa)
VRK1VRK serine/threonine kinase 1; Belongs to the protein kinase superfamily. (420 aa)
PRKACAProtein kinase cAMP-activated catalytic subunit alpha; Belongs to the protein kinase superfamily. (359 aa)
MAST4Microtubule associated serine/threonine kinase family member 4. (2642 aa)
NTRK2Tyrosine-protein kinase receptor. (838 aa)
STK4Serine/threonine kinase 4. (493 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (770 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (704 aa)
HIPK3Homeodomain interacting protein kinase 3. (1235 aa)
ENSECAP00000029278Uncharacterized protein. (229 aa)
ILKIntegrin linked kinase. (452 aa)
LATS2Non-specific serine/threonine protein kinase. (1088 aa)
CAMK1DCalcium/calmodulin dependent protein kinase ID. (395 aa)
MKNK2MAPK interacting serine/threonine kinase 2; Belongs to the protein kinase superfamily. (463 aa)
LOC100054462Histone domain-containing protein. (444 aa)
NEK6NIMA related kinase 6; Belongs to the protein kinase superfamily. (330 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (655 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa)
PKN1Protein kinase N1. (1098 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3076 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1732 aa)
RPS6KA1Ribosomal protein S6 kinase. (780 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (822 aa)
SYKTyrosine-protein kinase. (716 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (194 aa)
ENSECAP00000037240annotation not available (229 aa)
TTKTTK protein kinase. (864 aa)
CAMKVCaM kinase like vesicle associated. (501 aa)
TNKSPoly [ADP-ribose] polymerase. (1332 aa)
MARK3Non-specific serine/threonine protein kinase. (753 aa)
MAPK13Mitogen-activated protein kinase. (421 aa)
ENSECAP00000041641annotation not available (229 aa)
TSSK6Testis specific serine kinase 6; Belongs to the protein kinase superfamily. (273 aa)
PNCKPregnancy up-regulated nonubiquitous CaM kinase; Belongs to the protein kinase superfamily. (405 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4267 aa)
CSNK1A1Casein kinase 1 alpha 1; Belongs to the protein kinase superfamily. (380 aa)
MAP3K10Mitogen-activated protein kinase kinase kinase. (931 aa)
MAPKAPK3MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (403 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (585 aa)
STK32BSerine/threonine kinase 32B; Belongs to the protein kinase superfamily. (426 aa)
CSNK2A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (464 aa)
DYRK1ADual specificity tyrosine phosphorylation regulated kinase 1A. (763 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (249 aa)
STK32ASerine/threonine kinase 32A; Belongs to the protein kinase superfamily. (405 aa)
STK38Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (465 aa)
STK39Serine/threonine kinase 39. (556 aa)
MAST3Microtubule associated serine/threonine kinase 3. (1329 aa)
PKN2Protein kinase N2. (983 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (440 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
RPS6KA5Ribosomal protein S6 kinase. (799 aa)
TTBK2Tau tubulin kinase 2. (1244 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
STK38LNon-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (470 aa)
CAMK1Calcium/calmodulin dependent protein kinase I; Belongs to the protein kinase superfamily. (412 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
CDC7Cell division cycle 7. (575 aa)
PRKAA1Non-specific serine/threonine protein kinase. (633 aa)
DGKQDiacylglycerol kinase. (931 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (400 aa)
LOC100055155Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (431 aa)
AURKCAurora kinase C; Belongs to the protein kinase superfamily. (275 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
TLK2Tousled like kinase 2. (750 aa)
HIPK4Homeodomain interacting protein kinase 4. (616 aa)
VRK2VRK serine/threonine kinase 2. (507 aa)
TBK1TANK binding kinase 1. (729 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
DCLK3Doublecortin like kinase 3. (816 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
GSK3AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (483 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (697 aa)
SBK2SH3 domain binding kinase family member 2; Belongs to the protein kinase superfamily. (393 aa)
RPS6KA4Ribosomal protein S6 kinase. (771 aa)
PLK1Serine/threonine-protein kinase PLK. (604 aa)
MAPK12Mitogen-activated protein kinase. (365 aa)
ENSECAP00000014555H3 histone family member 3B. (136 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1059 aa)
CAMK4Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
TSSK4Testis specific serine kinase 4. (337 aa)
DYRK2Dual specificity tyrosine phosphorylation regulated kinase 2. (601 aa)
CLK1CDC like kinase 1. (614 aa)
CAB39Calcium binding protein 39. (373 aa)
PRPF4BPre-mRNA processing factor 4B. (1041 aa)
CAMK1GCalcium/calmodulin dependent protein kinase IG; Belongs to the protein kinase superfamily. (476 aa)
AURKBAurora kinase B; Belongs to the protein kinase superfamily. (344 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (350 aa)
PCK1Phosphoenolpyruvate carboxykinase 1. (622 aa)
PRKCHProtein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa)
SMG1SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3660 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (811 aa)
PBKPDZ binding kinase. (405 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
MYO3AMyosin IIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1614 aa)
RPS6KB2Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (483 aa)
RPS6KA3Ribosomal protein S6 kinase. (747 aa)
KIAA1549KIAA1549. (1953 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (974 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (892 aa)
LRRK2Leucine rich repeat kinase 2. (2528 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
CSNK1DCasein kinase 1 delta; Belongs to the protein kinase superfamily. (428 aa)
MAPKAPK5MAPK activated protein kinase 5. (473 aa)
SMTNL1Smoothelin like 1. (458 aa)
MAST2Microtubule associated serine/threonine kinase 2. (1806 aa)
STK32CSerine/threonine kinase 32C; Belongs to the protein kinase superfamily. (487 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (966 aa)
HIPK2Homeodomain interacting protein kinase 2. (1244 aa)
PINK1PTEN induced kinase 1. (585 aa)
AKT2Non-specific serine/threonine protein kinase. (528 aa)
LOC111774036Histone H3; Belongs to the histone H3 family. (136 aa)
SBK1Serine/threonine-protein kinase SBK1; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (417 aa)
TTBK1Tau tubulin kinase 1. (1409 aa)
CHEK2Checkpoint kinase 2. (544 aa)
DYRK1BDual specificity tyrosine phosphorylation regulated kinase 1B. (647 aa)
CSNK1G1Casein kinase 1 gamma 1; Belongs to the protein kinase superfamily. (482 aa)
MYO3BMyosin IIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1363 aa)
AURKAAurora kinase A; Belongs to the protein kinase superfamily. (423 aa)
MKNK1MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (454 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
PKN3Protein kinase N3. (908 aa)
DCLK1Doublecortin like kinase 1. (741 aa)
SGK1Non-specific serine/threonine protein kinase. (526 aa)
ATRATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (4382 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (594 aa)
RPS6KA6Ribosomal protein S6 kinase. (763 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (346 aa)
DYRK3Dual specificity tyrosine phosphorylation regulated kinase 3. (587 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2573 aa)
DYRK4NADH:ubiquinone oxidoreductase subunit A9. (609 aa)
TLK1Methyltransferase like 8. (1160 aa)
MAP4K1Mitogen-activated protein kinase kinase kinase kinase 1; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (855 aa)
RPS6KA2Ribosomal protein S6 kinase. (758 aa)
VRK3VRK serine/threonine kinase 3. (403 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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