(49 nodes) Arachidonic acid metabolic process network (Equus caballus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100070895	Uncharacterized protein; Belongs to the cytochrome P450 family. (500 aa)
	CYP2C113	Cytochrome P450 2C113; Belongs to the cytochrome P450 family. (490 aa)
	LOC100061609	Uncharacterized protein; Belongs to the cytochrome P450 family. (490 aa)
	CYP2S1	Cytochrome P450 family 2 subfamily S member 1. (587 aa)
	DAGLA	Diacylglycerol lipase alpha. (1040 aa)
	LOC100061502	Uncharacterized protein; Belongs to the cytochrome P450 family. (490 aa)
	LOC100061400	Uncharacterized protein; Belongs to the cytochrome P450 family. (490 aa)
	ENSECAP00000042890	Uncharacterized protein. (145 aa)
	LOC100068334	Uncharacterized protein. (453 aa)
	LOC100146596	Uncharacterized protein; Belongs to the cytochrome P450 family. (518 aa)
	ENSECAP00000045215	Uncharacterized protein. (77 aa)
	ALOX5	Arachidonate 5-lipoxygenase. (685 aa)
	LOC100070990	Uncharacterized protein; Belongs to the cytochrome P450 family. (500 aa)
	LOC100070962	Uncharacterized protein; Belongs to the cytochrome P450 family. (500 aa)
	CYP2E1	Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family. (538 aa)
	PTGS1	Prostaglandin-endoperoxide synthase 1. (599 aa)
	F6Y9C9_HORSE	Uncharacterized protein; Belongs to the cytochrome P450 family. (501 aa)
	ALOX12	Arachidonate 12-lipoxygenase, 12S type. (663 aa)
	HADH	Cytochrome P450 family 2 subfamily U member 1; Belongs to the cytochrome P450 family. (511 aa)
	PLA2G2F	Phospholipase A(2). (210 aa)
	SRP9	Epoxide hydrolase 1. (491 aa)
	CYP1B1	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (560 aa)
	PTGS2	Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (666 aa)
	DAGLB	Diacylglycerol lipase beta. (672 aa)
	ALOXE3	Arachidonate lipoxygenase 3. (711 aa)
	ALOX12B	Arachidonate 12-lipoxygenase, 12R type. (699 aa)
	ALOX15B	Arachidonate 15-lipoxygenase type B. (677 aa)
	LOC100068569	Uncharacterized protein; Belongs to the cytochrome P450 family. (578 aa)
	LOC100061542	Uncharacterized protein; Belongs to the cytochrome P450 family. (532 aa)
	LOC100146413	Uncharacterized protein. (526 aa)
	CYP2A13	Uncharacterized protein; Belongs to the cytochrome P450 family. (529 aa)
	CYP1A2	Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (516 aa)
	LOC111775200	Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
	CYP2B6	Cytochrome P450 family 2 subfamily B member 6; Belongs to the cytochrome P450 family. (508 aa)
	MGLL	Monoglyceride lipase. (346 aa)
	CYP2C92	Uncharacterized protein; Belongs to the cytochrome P450 family. (491 aa)
	LOC100068295	Uncharacterized protein. (488 aa)
	LOC100061367	Uncharacterized protein; Belongs to the cytochrome P450 family. (495 aa)
	LOC100068510	Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
	LOC100070400	Uncharacterized protein; Belongs to the cytochrome P450 family. (536 aa)
	GPX4	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (199 aa)
	CYP2D50	CYP2D50; Belongs to the cytochrome P450 family. (500 aa)
	ENSECAP00000026804	Uncharacterized protein; Belongs to the cytochrome P450 family. (491 aa)
	LOC100147480	Uncharacterized protein; Belongs to the cytochrome P450 family. (500 aa)
	CYP2F1	Cytochrome P450 family 2 subfamily F member 1; Belongs to the cytochrome P450 family. (504 aa)
	PLA2G4A	Cytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response. (749 aa)
	LOC100056087	Uncharacterized protein; Belongs to the cytochrome P450 family. (500 aa)
	PNPLA8	Patatin like phospholipase domain containing 8. (779 aa)
	LOC100070905	Uncharacterized protein; Belongs to the cytochrome P450 family. (500 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALOX12	ALOX12B	ENSECAP00000019594	ENSECAP00000010462	Arachidonate 12-lipoxygenase, 12S type.	Arachidonate 12-lipoxygenase, 12R type.	0.906
ALOX12	ALOX15B	ENSECAP00000019594	ENSECAP00000010415	Arachidonate 12-lipoxygenase, 12S type.	Arachidonate 15-lipoxygenase type B.	0.454
ALOX12	ALOX5	ENSECAP00000019594	ENSECAP00000045479	Arachidonate 12-lipoxygenase, 12S type.	Arachidonate 5-lipoxygenase.	0.937
ALOX12	ALOXE3	ENSECAP00000019594	ENSECAP00000010948	Arachidonate 12-lipoxygenase, 12S type.	Arachidonate lipoxygenase 3.	0.412
ALOX12	CYP2B6	ENSECAP00000019594	ENSECAP00000005978	Arachidonate 12-lipoxygenase, 12S type.	Cytochrome P450 family 2 subfamily B member 6; Belongs to the cytochrome P450 family.	0.904
ALOX12	CYP2C113	ENSECAP00000019594	ENSECAP00000036670	Arachidonate 12-lipoxygenase, 12S type.	Cytochrome P450 2C113; Belongs to the cytochrome P450 family.	0.904
ALOX12	HADH	ENSECAP00000019594	ENSECAP00000018872	Arachidonate 12-lipoxygenase, 12S type.	Cytochrome P450 family 2 subfamily U member 1; Belongs to the cytochrome P450 family.	0.904
ALOX12	LOC100061367	ENSECAP00000019594	ENSECAP00000000223	Arachidonate 12-lipoxygenase, 12S type.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.904
ALOX12	LOC100061400	ENSECAP00000019594	ENSECAP00000041885	Arachidonate 12-lipoxygenase, 12S type.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.904
ALOX12	LOC100061542	ENSECAP00000019594	ENSECAP00000009002	Arachidonate 12-lipoxygenase, 12S type.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.904
ALOX12	LOC100068569	ENSECAP00000019594	ENSECAP00000009682	Arachidonate 12-lipoxygenase, 12S type.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.905
ALOX12	LOC100070400	ENSECAP00000019594	ENSECAP00000022467	Arachidonate 12-lipoxygenase, 12S type.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.905
ALOX12	PLA2G2F	ENSECAP00000019594	ENSECAP00000018404	Arachidonate 12-lipoxygenase, 12S type.	Phospholipase A(2).	0.714
ALOX12	PLA2G4A	ENSECAP00000019594	ENSECAP00000030001	Arachidonate 12-lipoxygenase, 12S type.	Cytosolic phospholipase A2; Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.	0.729
ALOX12	PTGS1	ENSECAP00000019594	ENSECAP00000007887	Arachidonate 12-lipoxygenase, 12S type.	Prostaglandin-endoperoxide synthase 1.	0.920
ALOX12	PTGS2	ENSECAP00000019594	ENSECAP00000015107	Arachidonate 12-lipoxygenase, 12S type.	Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...]	0.926
ALOX12B	ALOX12	ENSECAP00000010462	ENSECAP00000019594	Arachidonate 12-lipoxygenase, 12R type.	Arachidonate 12-lipoxygenase, 12S type.	0.906
ALOX12B	ALOX5	ENSECAP00000010462	ENSECAP00000045479	Arachidonate 12-lipoxygenase, 12R type.	Arachidonate 5-lipoxygenase.	0.939
ALOX12B	ALOXE3	ENSECAP00000010462	ENSECAP00000010948	Arachidonate 12-lipoxygenase, 12R type.	Arachidonate lipoxygenase 3.	0.406
ALOX12B	CYP2B6	ENSECAP00000010462	ENSECAP00000005978	Arachidonate 12-lipoxygenase, 12R type.	Cytochrome P450 family 2 subfamily B member 6; Belongs to the cytochrome P450 family.	0.904