STRINGSTRING
RAC3 RAC3 APBB1 APBB1 TLR9-2 TLR9-2 ABITRAM ABITRAM STX2 STX2 LOC100064912 LOC100064912 CORO1B CORO1B LOC100061466 LOC100061466 LOC100147550 LOC100147550 BCAR1 BCAR1 TTN TTN AIF1 AIF1 CARMIL3 CARMIL3 SNX1 SNX1 ENSECAP00000049244 ENSECAP00000049244 DBNL DBNL CAPRIN1 CAPRIN1 CORO1C CORO1C ARHGEF7 ARHGEF7 ITGB1 ITGB1 SYNE2 SYNE2 CTTN CTTN PARVB PARVB ACTR3B ACTR3B FSCN1 FSCN1 PODXL PODXL MYH10 MYH10 PDPN PDPN ITGAV ITGAV ENSECAP00000041955 ENSECAP00000041955 LIMK1 LIMK1 PABPC1 PABPC1 CIB3 CIB3 ABI3 ABI3 PARVA PARVA ACTC1 ACTC1 EVL EVL ACTN1 ACTN1 AMOT AMOT ARHGAP31 ARHGAP31 FAM89B FAM89B APC APC MYLK MYLK RAC2 RAC2 ABI2 ABI2 DPP4 DPP4 RAC1 RAC1 PALLD PALLD ACTG2 ACTG2 ABI1 ABI1 VAMP7 VAMP7 PDLIM4 PDLIM4 NF2 NF2 CCDC88A CCDC88A CD44 CD44 APC2 APC2 DPYSL3 DPYSL3 PIP5K1A PIP5K1A CAPG CAPG PLXND1 PLXND1 VILL VILL ILK ILK SNX2 SNX2 RAB13 RAB13 DGKZ DGKZ GSN GSN SPATA13 SPATA13 CYFIP1 CYFIP1 GDPD2 GDPD2 CDC42 CDC42 CDC42BPB CDC42BPB ENSECAP00000024196 ENSECAP00000024196 PTK2B PTK2B ACTA2 ACTA2 HAX1 HAX1 PKN2 PKN2 CORO1A CORO1A CARMIL1 CARMIL1 CDK5 CDK5 PKD2 PKD2 ITGB1BP1 ITGB1BP1 CLRN3 CLRN3 ARPIN ARPIN PLCE1 PLCE1 PHACTR4 PHACTR4 WASF1 WASF1 SCYL3 SCYL3 FLOT1 FLOT1 ROCK1 ROCK1 PLCG1 PLCG1 SH3RF1 SH3RF1 FSCN3 FSCN3 ACTR3 ACTR3 ARPC3 ARPC3 CFL1 CFL1 UNC5C UNC5C ARPC5 ARPC5 ITGB3 ITGB3 PAK1 PAK1 MYO1G MYO1G KPTN KPTN CIB1 CIB1 STMN2 STMN2 SPEF1 SPEF1 BRK1 BRK1 INPPL1 INPPL1 ABLIM3 ABLIM3 ACTB ACTB WASL WASL PIK3CA PIK3CA MEFV MEFV TSC1 TSC1 ALS2 ALS2 WASF2 WASF2 VIL1 VIL1 CARMIL2 CARMIL2 PPP1R9B PPP1R9B FLOT2 FLOT2 ARHGEF6 ARHGEF6 IQGAP2 IQGAP2 PLEKHH2 PLEKHH2 F6SXQ9_HORSE F6SXQ9_HORSE PDXP PDXP KCNA2 KCNA2 CLRN1 CLRN1 KITLG KITLG ACTA1 ACTA1 WASF3 WASF3 TUBB3 TUBB3 FAT1 FAT1 STX3 STX3 FGD1 FGD1 SH3BP1 SH3BP1 SLC39A6 SLC39A6 MYO10 MYO10 VASP VASP EPHA2 EPHA2 P4HB P4HB AJUBA AJUBA IGF2BP1 IGF2BP1 RAPGEF3 RAPGEF3 CORO6 CORO6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAC3Rac family small GTPase 3. (192 aa)
APBB1Amyloid beta precursor protein binding family B member 1. (772 aa)
TLR9-2Toll-like receptor 9. (349 aa)
ABITRAMActin binding transcription modulator. (181 aa)
STX2Syntaxin 2; Belongs to the syntaxin family. (459 aa)
LOC100064912Death domain-containing protein. (230 aa)
CORO1BCoronin; Belongs to the WD repeat coronin family. (489 aa)
LOC100061466Uncharacterized protein; Belongs to the actin family. (371 aa)
LOC100147550Uncharacterized protein. (235 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (887 aa)
TTNTitin. (32000 aa)
AIF1Allograft inflammatory factor 1. (161 aa)
CARMIL3Capping protein regulator and myosin 1 linker 3. (1552 aa)
SNX1Sorting nexin 1. (541 aa)
ENSECAP00000049244Uncharacterized protein. (631 aa)
DBNLDrebrin like. (565 aa)
CAPRIN1Cell cycle associated protein 1. (693 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (525 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (893 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (808 aa)
SYNE2Spectrin repeat containing nuclear envelope protein 2. (6914 aa)
CTTNCortactin. (559 aa)
PARVBParvin beta. (410 aa)
ACTR3BUncharacterized protein; Belongs to the actin family. (465 aa)
FSCN1Fascin actin-bundling protein 1. (667 aa)
PODXLUncharacterized protein. (777 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1997 aa)
PDPNUncharacterized protein. (152 aa)
ITGAVFamily with sequence similarity 171 member B; Belongs to the integrin alpha chain family. (1787 aa)
ENSECAP00000041955Uncharacterized protein. (234 aa)
LIMK1LIM domain kinase 1. (789 aa)
PABPC1Uncharacterized protein. (648 aa)
CIB3Calcium and integrin binding family member 3. (187 aa)
ABI3ABI family member 3. (521 aa)
PARVAParvin alpha. (459 aa)
ACTC1Actin alpha cardiac muscle 1. (377 aa)
EVLEnah/Vasp-like. (494 aa)
ACTN1Actinin alpha 1. (959 aa)
AMOTAngiomotin. (1089 aa)
ARHGAP31Rho GTPase activating protein 31. (1452 aa)
FAM89BFamily with sequence similarity 89 member B. (192 aa)
APCAPC regulator of WNT signaling pathway. (2873 aa)
MYLKMyosin light chain kinase. (2069 aa)
RAC2Rac family small GTPase 2. (192 aa)
ABI2Abl interactor 2. (513 aa)
DPP4Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (869 aa)
RAC1Rac family small GTPase 1. (221 aa)
PALLDPalladin, cytoskeletal associated protein. (1449 aa)
ACTG2Actin gamma 2, smooth muscle; Belongs to the actin family. (408 aa)
ABI1Abl interactor 1. (508 aa)
VAMP7Vesicle associated membrane protein 7; Belongs to the synaptobrevin family. (276 aa)
PDLIM4PDZ and LIM domain 4. (437 aa)
NF2Neurofibromin 2. (637 aa)
CCDC88ACoiled-coil domain containing 88A. (2029 aa)
CD44CD44 antigen. (700 aa)
APC2APC regulator of WNT signaling pathway 2. (2301 aa)
DPYSL3Dihydropyrimidinase like 3. (684 aa)
PIP5K1APIPK domain-containing protein. (565 aa)
CAPGCapping actin protein, gelsolin like. (446 aa)
PLXND1Plexin D1. (2046 aa)
VILLVillin like. (857 aa)
ILKIntegrin linked kinase. (452 aa)
SNX2Sorting nexin 2. (522 aa)
RAB13RAB13, member RAS oncogene family. (273 aa)
DGKZDiacylglycerol kinase. (1111 aa)
GSNGelsolin; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis (By similarity). (871 aa)
SPATA13Uncharacterized protein. (1256 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1225 aa)
GDPD2Glycerophosphodiester phosphodiesterase domain containing 2. (540 aa)
CDC42Cell division control protein 42-like protein. (191 aa)
CDC42BPBCDC42 binding protein kinase beta; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1728 aa)
ENSECAP00000024196DAGKa domain-containing protein. (363 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1081 aa)
ACTA2Actin alpha 2, smooth muscle. (406 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (284 aa)
PKN2Protein kinase N2. (983 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
CARMIL1Capping protein regulator and myosin 1 linker 1. (1432 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (958 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
CLRN3Clarin 3. (229 aa)
ARPINUncharacterized protein. (226 aa)
PLCE1Phosphoinositide phospholipase C. (2299 aa)
PHACTR4Phosphatase and actin regulator. (744 aa)
WASF1WASP family member 1. (572 aa)
SCYL3SCY1 like pseudokinase 3. (739 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
SH3RF1SH3 domain containing ring finger 1. (886 aa)
FSCN3Fascin. (498 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (418 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
CFL1Cofilin 1; Belongs to the actin-binding proteins ADF family. (166 aa)
UNC5CUnc-5 netrin receptor C. (931 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (154 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
MYO1GMyosin IG; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1014 aa)
KPTNKaptin, actin binding protein. (669 aa)
CIB1Calcium and integrin binding 1. (191 aa)
STMN2Stathmin; Belongs to the stathmin family. (179 aa)
SPEF1Sperm flagellar 1. (343 aa)
BRK1BRICK1 subunit of SCAR/WAVE actin nucleating complex. (75 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1264 aa)
ABLIM3Actin binding LIM protein family member 3. (683 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (377 aa)
WASLWASP like actin nucleation promoting factor. (505 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
MEFVMEFV innate immuity regulator, pyrin. (117 aa)
TSC1TSC complex subunit 1. (1232 aa)
ALS2Alsin Rho guanine nucleotide exchange factor ALS2. (1657 aa)
WASF2WASP family member 2. (498 aa)
VIL1Villin 1. (827 aa)
CARMIL2Capping protein regulator and myosin 1 linker 2. (1405 aa)
PPP1R9BProtein phosphatase 1 regulatory subunit 9B. (821 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor 6. (776 aa)
IQGAP2IQ motif containing GTPase activating protein 2. (1576 aa)
PLEKHH2Pleckstrin homology, MyTH4 and FERM domain containing H2. (1493 aa)
F6SXQ9_HORSEUncharacterized protein. (191 aa)
PDXPPyridoxal phosphatase; Belongs to the HAD-like hydrolase superfamily. (296 aa)
KCNA2Potassium voltage-gated channel subfamily A member 2; Belongs to the potassium channel family. (499 aa)
CLRN1Clarin 1. (232 aa)
KITLGProcessed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family. (303 aa)
ACTA1Actin alpha 1, skeletal muscle. (377 aa)
WASF3WASP family member 3. (502 aa)
TUBB3Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
FAT1FAT atypical cadherin 1. (4590 aa)
STX3Syntaxin 3; Belongs to the syntaxin family. (306 aa)
FGD1FYVE, RhoGEF and PH domain containing 1. (960 aa)
SH3BP1SH3 domain binding protein 1. (701 aa)
SLC39A6Solute carrier family 39 member 6. (735 aa)
MYO10Myosin X; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2056 aa)
VASPVasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (385 aa)
EPHA2EPH receptor A2. (975 aa)
P4HBProtein disulfide-isomerase. (510 aa)
AJUBAAjuba LIM protein. (584 aa)
IGF2BP1Insulin like growth factor 2 mRNA binding protein 1. (577 aa)
RAPGEF3Rap guanine nucleotide exchange factor 3. (923 aa)
CORO6Coronin; Belongs to the WD repeat coronin family. (472 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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