STRINGSTRING
FFAR4 FFAR4 RAF1 RAF1 IL1RN IL1RN CYB5R4 CYB5R4 ENSECAP00000050004 ENSECAP00000050004 AQP1 AQP1 HIF1A HIF1A CDK16 CDK16 PCLO PCLO RAPGEF4 RAPGEF4 TRPV4 TRPV4 ENSECAP00000039203 ENSECAP00000039203 LEP LEP SNX19 SNX19 RAB11FIP5 RAB11FIP5 SELENOT SELENOT VGF VGF LOC111773841 LOC111773841 FKBP1B FKBP1B ADCYAP1 ADCYAP1 STXBP3 STXBP3 ACVR1C ACVR1C CRHR1 CRHR1 HNF1A HNF1A RAB11FIP2 RAB11FIP2 GHSR GHSR SLC30A8 SLC30A8 PARK7 PARK7 ANXA1 ANXA1 HNF1B HNF1B GHRHR GHRHR ILDR2 ILDR2 ILDR1 ILDR1 VIP VIP PTPRN2 PTPRN2 EDN1 EDN1 CCDC186 CCDC186 CPE CPE CPLX3 CPLX3 GPR68 GPR68 GPR119 GPR119 PRKCE PRKCE EXOC3L1 EXOC3L1 PDX1 PDX1 SMPD3 SMPD3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FFAR4Free fatty acid receptor 4. (361 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)
IL1RNInterleukin-1 receptor antagonist protein; Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity; Belongs to the IL-1 family. (177 aa)
CYB5R4Cytochrome b5 reductase 4. (551 aa)
ENSECAP00000050004Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (323 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (307 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (844 aa)
CDK16Cyclin dependent kinase 16. (573 aa)
PCLOPiccolo presynaptic cytomatrix protein. (5231 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4. (1097 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (857 aa)
ENSECAP00000039203Uncharacterized protein. (223 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (189 aa)
SNX19Sorting nexin 19. (998 aa)
RAB11FIP5RAB11 family interacting protein 5. (1305 aa)
SELENOTSelenoprotein T; Belongs to the SelWTH family. Selenoprotein T subfamily. (194 aa)
VGFVGF nerve growth factor inducible. (616 aa)
LOC111773841G_PROTEIN_RECEP_F1_2 domain-containing protein. (358 aa)
FKBP1BPeptidylprolyl isomerase. (223 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (170 aa)
STXBP3Pre-mRNA processing factor 38B; Belongs to the STXBP/unc-18/SEC1 family. (1126 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (492 aa)
CRHR1Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (415 aa)
HNF1AHNF1 homeobox A. (631 aa)
RAB11FIP2RAB11 family interacting protein 2. (512 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
SLC30A8Solute carrier family 30 member 8. (369 aa)
PARK7Parkinsonism associated deglycase. (268 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (346 aa)
HNF1BHNF1 homeobox B. (558 aa)
GHRHRGrowth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (423 aa)
ILDR2Immunoglobulin like domain containing receptor 2. (639 aa)
ILDR1Immunoglobulin like domain containing receptor 1. (643 aa)
VIPVasoactive intestinal peptide. (171 aa)
PTPRN2Protein tyrosine phosphatase receptor type N2. (1005 aa)
EDN1Endothelin 1. (202 aa)
CCDC186Coiled-coil domain containing 186. (1009 aa)
CPECarboxypeptidase E. (476 aa)
CPLX3Complexin 3. (158 aa)
GPR68G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (389 aa)
GPR119G protein-coupled receptor 119; Belongs to the G-protein coupled receptor 1 family. (335 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
EXOC3L1Exocyst complex component 3 like 1. (794 aa)
PDX1Pancreatic and duodenal homeobox 1. (282 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (658 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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