STRINGSTRING
LMBR1 LMBR1 TP63 TP63 TULP3 TULP3 MKS1 MKS1 HOXC11 HOXC11 ALX3 ALX3 WDR19 WDR19 TBX2 TBX2 TBX4 TBX4 LRP4 LRP4 TMEM231 TMEM231 NOTCH1 NOTCH1 SHH SHH CYP26B1 CYP26B1 RPGRIP1L RPGRIP1L HOXD9 HOXD9 BMPR1A BMPR1A FREM2 FREM2 HOXD10 HOXD10 MSX1 MSX1 HOXD13 HOXD13 HNF1A HNF1A ALX4 ALX4 DLX5 DLX5 MEGF8 MEGF8 NIPBL NIPBL GDF5 GDF5 DLX6 DLX6 FGF9 FGF9 SALL4 SALL4 FLVCR1 FLVCR1 BMP4 BMP4 TBX5 TBX5 SFRP2 SFRP2 RARB RARB RARG RARG ECE1 ECE1 ALDH1A2 ALDH1A2 PITX1 PITX1 TMEM107 TMEM107 B9D1 B9D1 HOXA11 HOXA11 C2CD3 C2CD3 SALL1 SALL1 RECK RECK GPC3 GPC3 MED1 MED1 HAND2 HAND2 IFT140 IFT140 LNPK LNPK HOXA9 HOXA9 FRAS1 FRAS1 RDH10 RDH10 IHH IHH CHD7 CHD7 HOXD12 HOXD12 GREM1 GREM1 MAP3K20 MAP3K20 PTCH1 PTCH1 EN1 EN1 TBX3 TBX3 BCL2L11 BCL2L11 IFT52 IFT52 NOTCH2 NOTCH2 GLI3 GLI3 INTU INTU HOXA13 HOXA13 GAS1 GAS1 CHST11 CHST11 FGF4 FGF4 ZBTB16 ZBTB16 LEF1 LEF1 LRP5 LRP5 TBC1D32 TBC1D32 OSR2 OSR2 SP9 SP9 IMPAD1 IMPAD1 GNA12 GNA12 TFAP2A TFAP2A HOXC10 HOXC10 SP8 SP8 RUNX2 RUNX2 WDPCP WDPCP SMAD4 SMAD4 OSR1 OSR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LMBR1Limb development membrane protein 1; Belongs to the LIMR family. (550 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
TULP3Tubby like protein 3; Belongs to the TUB family. (628 aa)
MKS1MKS transition zone complex subunit 1. (793 aa)
HOXC11Homeobox C11. (307 aa)
ALX3ALX homeobox 3. (343 aa)
WDR19WD repeat domain 19. (1342 aa)
TBX2T-box transcription factor 2. (755 aa)
TBX4T-box transcription factor 4. (552 aa)
LRP4LDL receptor related protein 4. (1905 aa)
TMEM231Transmembrane protein 231. (318 aa)
NOTCH1Notch receptor 1. (2581 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
RPGRIP1LRPGRIP1 like. (1289 aa)
HOXD9Homeobox D9. (350 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
FREM2FRAS1 related extracellular matrix 2. (3174 aa)
HOXD10Homeobox D10. (410 aa)
MSX1Msh homeobox 1. (303 aa)
HOXD13Homeobox D13. (341 aa)
HNF1AHNF1 homeobox A. (631 aa)
ALX4ALX homeobox 4. (408 aa)
DLX5Distal-less homeobox 5. (289 aa)
MEGF8Multiple EGF like domains 8. (2789 aa)
NIPBLNipped-B protein. (2805 aa)
GDF5Growth differentiation factor 5. (499 aa)
DLX6Distal-less homeobox 6. (202 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SALL4Spalt like transcription factor 4. (1056 aa)
FLVCR1Feline leukemia virus subgroup C cellular receptor 1. (555 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
TBX5T-box transcription factor 5. (518 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
RARBRetinoic acid receptor beta. (448 aa)
RARGRetinoic acid receptor gamma. (541 aa)
ECE1Endothelin converting enzyme 1. (779 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
PITX1Homeobox protein. (314 aa)
TMEM107Transmembrane protein 107. (140 aa)
B9D1B9 domain containing 1. (204 aa)
HOXA11Homeobox A11. (316 aa)
C2CD3C2 domain containing 3 centriole elongation regulator. (2342 aa)
SALL1Spalt like transcription factor 1. (1313 aa)
RECKReversion inducing cysteine rich protein with kazal motifs. (970 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (611 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
IFT140Intraflagellar transport 140. (1463 aa)
LNPKLunapark, ER junction formation factor. (429 aa)
HOXA9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (272 aa)
FRAS1Fraser extracellular matrix complex subunit 1. (4011 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2995 aa)
HOXD12Homeobox D12. (270 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (143 aa)
MAP3K20Uncharacterized protein. (850 aa)
PTCH1Patched 1. (1490 aa)
EN1Homeobox protein engrailed-like. (393 aa)
TBX3T-box transcription factor 3. (745 aa)
BCL2L11BCL2 like 11. (289 aa)
IFT52Intraflagellar transport 52. (450 aa)
NOTCH2Notch receptor 2. (2471 aa)
GLI3GLI family zinc finger 3. (1581 aa)
INTUInturned planar cell polarity protein. (938 aa)
HOXA13Homeobox A13. (388 aa)
GAS1Growth arrest specific 1. (372 aa)
CHST11Carbohydrate sulfotransferase. (372 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
ZBTB16Zinc finger and BTB domain containing 16. (673 aa)
LEF1Lymphoid enhancer binding factor 1. (413 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
TBC1D32TBC1 domain family member 32. (1243 aa)
OSR2Odd-skipped related transciption factor 2. (288 aa)
SP9Sp9 transcription factor. (484 aa)
IMPAD1Inositol monophosphatase domain containing 1. (360 aa)
GNA12G protein subunit alpha 12. (455 aa)
TFAP2ATranscription factor AP-2 alpha. (449 aa)
HOXC10Homeobox C10. (342 aa)
SP8Sp8 transcription factor. (662 aa)
RUNX2Runt-related transcription factor 2; Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. Inhibits KAT6B-dependent transcriptional activation. In osteoblasts, supports transcription activati [...] (634 aa)
WDPCPWD repeat containing planar cell polarity effector. (714 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
OSR1Odd-skipped related transcription factor 1. (279 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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