STRINGSTRING
PKDCC PKDCC ATRAID ATRAID AHSG AHSG ACVR2B ACVR2B GPM6B GPM6B HIF1A HIF1A BMPR1B BMPR1B ALOX5 ALOX5 SLC8A3 SLC8A3 NOTUM NOTUM BCOR BCOR ACVR2A ACVR2A NBR1 NBR1 COMP COMP ANKH ANKH ANO6 ANO6 OSR2 OSR2 LTF LTF WNT10B WNT10B DDR2 DDR2 TGFB3 TGFB3 BMP2K BMP2K TFAP2A TFAP2A PTN PTN LTBP3 LTBP3 MEF2C MEF2C OSR1 OSR1 PTK2B PTK2B CYP27B1 CYP27B1 BMPR2 BMPR2 CCN1 CCN1 BGLAP BGLAP SOX9 SOX9 BMP2 BMP2 FGF23 FGF23 BMPR1A BMPR1A BMP6 BMP6 ACTN3 ACTN3 PTH PTH BMP4 BMP4 CYP27C1 CYP27C1 TXLNG TXLNG OMD OMD TENT5A TENT5A ENPP1 ENPP1 TGFB1 TGFB1 MGP MGP GATA1 GATA1 P2RX7 P2RX7 ATP2B1 ATP2B1 SRGN SRGN MATN1 MATN1 ECM1 ECM1 RFLNB RFLNB ZMPSTE24 ZMPSTE24 RFLNA RFLNA GREM1 GREM1 ISG15 ISG15 TMEM119 TMEM119
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PKDCCProtein kinase domain containing, cytoplasmic. (493 aa)
ATRAIDAll-trans retinoic acid induced differentiation factor. (229 aa)
AHSGAlpha 2-HS glycoprotein. (398 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (577 aa)
GPM6BGlycoprotein M6B. (328 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (844 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (547 aa)
ALOX5Arachidonate 5-lipoxygenase. (685 aa)
SLC8A3Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (928 aa)
NOTUMNotum, palmitoleoyl-protein carboxylesterase. (727 aa)
BCORBCL6 corepressor. (1733 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (521 aa)
NBR1NBR1 autophagy cargo receptor. (985 aa)
COMPCartilage oligomeric matrix protein. (793 aa)
ANKHANKH inorganic pyrophosphate transport regulator. (864 aa)
ANO6Anoctamin. (996 aa)
OSR2Odd-skipped related transciption factor 2. (288 aa)
LTFLactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites. (715 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
TGFB3Transforming growth factor beta 3. (490 aa)
BMP2KBMP2 inducible kinase. (1137 aa)
TFAP2ATranscription factor AP-2 alpha. (449 aa)
PTNPleiotrophin. (192 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1554 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
OSR1Odd-skipped related transcription factor 1. (279 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1081 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
CCN1Cellular communication network factor 1. (382 aa)
BGLAPOsteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. (100 aa)
SOX9SRY-box 9. (509 aa)
BMP2Bone morphogenetic protein 2. (397 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (244 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
BMP6Bone morphogenetic protein 6. (506 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (902 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D- glucose (2DG) transport and glycogen synthesis in osteoblastic cells (By similarity). (115 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
CYP27C1Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (547 aa)
TXLNGTaxilin gamma. (734 aa)
OMDOsteomodulin. (418 aa)
TENT5ATerminal nucleotidyltransferase 5A. (453 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (1043 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
MGPMatrix Gla protein; Associates with the organic matrix of bone and cartilage. (103 aa)
GATA1GATA binding protein 1. (486 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1249 aa)
SRGNSerglycin. (156 aa)
MATN1Matrilin 1. (521 aa)
ECM1Extracellular matrix protein 1. (543 aa)
RFLNBRefilin B. (218 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
RFLNARefilin A. (213 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (143 aa)
ISG15ISG15 ubiquitin like modifier. (164 aa)
TMEM119Transmembrane protein 119. (275 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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