(14 nodes) Intracellular estrogen receptor signaling pathway network (Equus caballus)

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Known Interactions

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Predicted Interactions

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Your Input:
	AR	Androgen receptor. (882 aa)
	DDX5	DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
	PHB2	Prohibitin. (299 aa)
	ARID1A	AT-rich interaction domain 1A. (2211 aa)
	PPARGC1B	PPARG coactivator 1 beta. (1239 aa)
	POU4F2	POU domain protein. (406 aa)
	PADI2	Peptidyl arginine deiminase 2. (665 aa)
	ESR1	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (608 aa)
	TRIP4	Thyroid hormone receptor interactor 4. (581 aa)
	ESR2	Estrogen receptor 2. (550 aa)
	DDX17	DEAD-box helicase 17; Belongs to the DEAD box helicase family. (729 aa)
	ENSECAP00000039988	Prohibitin. (299 aa)
	RBFOX2	RNA binding fox-1 homolog 2. (476 aa)
	SAFB	Scaffold attachment factor B. (977 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	ARID1A	ENSECAP00000008070	ENSECAP00000016142	Androgen receptor.	AT-rich interaction domain 1A.	0.490
AR	DDX5	ENSECAP00000008070	ENSECAP00000009394	Androgen receptor.	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	0.538
AR	ESR1	ENSECAP00000008070	ENSECAP00000020141	Androgen receptor.	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	0.663
AR	ESR2	ENSECAP00000008070	ENSECAP00000022532	Androgen receptor.	Estrogen receptor 2.	0.454
ARID1A	AR	ENSECAP00000016142	ENSECAP00000008070	AT-rich interaction domain 1A.	Androgen receptor.	0.490
DDX17	DDX5	ENSECAP00000029826	ENSECAP00000009394	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	0.805
DDX17	ESR1	ENSECAP00000029826	ENSECAP00000020141	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	0.729
DDX17	ESR2	ENSECAP00000029826	ENSECAP00000022532	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	Estrogen receptor 2.	0.561
DDX5	AR	ENSECAP00000009394	ENSECAP00000008070	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Androgen receptor.	0.538
DDX5	DDX17	ENSECAP00000009394	ENSECAP00000029826	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	0.805
DDX5	ESR1	ENSECAP00000009394	ENSECAP00000020141	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	0.814
DDX5	ESR2	ENSECAP00000009394	ENSECAP00000022532	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Estrogen receptor 2.	0.561
ENSECAP00000039988	ESR1	ENSECAP00000039988	ENSECAP00000020141	Prohibitin.	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	0.625
ENSECAP00000039988	ESR2	ENSECAP00000039988	ENSECAP00000022532	Prohibitin.	Estrogen receptor 2.	0.418
ESR1	AR	ENSECAP00000020141	ENSECAP00000008070	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	Androgen receptor.	0.663
ESR1	DDX17	ENSECAP00000020141	ENSECAP00000029826	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	0.729
ESR1	DDX5	ENSECAP00000020141	ENSECAP00000009394	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	0.814
ESR1	ENSECAP00000039988	ENSECAP00000020141	ENSECAP00000039988	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	Prohibitin.	0.625
ESR1	ESR2	ENSECAP00000020141	ENSECAP00000022532	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	Estrogen receptor 2.	0.997
ESR1	PHB2	ENSECAP00000020141	ENSECAP00000014670	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	Prohibitin.	0.722