(30 nodes) Collagen catabolic process network (Equus caballus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	MMP14	Matrix metallopeptidase 14. (581 aa)
	MRC2	Mannose receptor C type 2. (1482 aa)
	MMP20	Matrix metallopeptidase 20. (483 aa)
	MMP25	Matrix metallopeptidase 25. (559 aa)
	MMP15	Matrix metallopeptidase 15. (912 aa)
	MMP19	Matrix metallopeptidase 19. (507 aa)
	MMP17	Matrix metallopeptidase 17. (707 aa)
	MMP9	Matrix metallopeptidase 9. (714 aa)
	RETREG2	Reticulophagy regulator family member 2. (537 aa)
	MMP11	Matrix metallopeptidase 11. (489 aa)
	CTSL	Cathepsin L; Belongs to the peptidase C1 family. (358 aa)
	MMP16	Matrix metallopeptidase 16. (622 aa)
	MMP27	Matrix metallopeptidase 27. (511 aa)
	RETREG3	Reticulophagy regulator family member 3. (466 aa)
	MMP7	Matrix metallopeptidase 7. (267 aa)
	MMP1	Interstitial collagenase. (520 aa)
	CTSS	Cathepsin S; Belongs to the peptidase C1 family. (332 aa)
	PEPD	Peptidase D. (493 aa)
	MMP24	Matrix metallopeptidase 24. (591 aa)
	MMP2	Matrix metallopeptidase 2. (659 aa)
	CTSV	Cathepsin V; Belongs to the peptidase C1 family. (394 aa)
	MMP26	Matrix metallopeptidase 26. (261 aa)
	RETREG1	Reticulophagy regulator 1. (495 aa)
	MMP21	Matrix metallopeptidase 21. (564 aa)
	ADAMTS2	ADAM metallopeptidase with thrombospondin type 1 motif 2. (1423 aa)
	MMP23B	Matrix metallopeptidase 23B. (676 aa)
	CTSK	Cathepsin K; Belongs to the peptidase C1 family. (329 aa)
	MMP3	Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase; Belongs to the peptidase M10A family. (477 aa)
	MMP28	Matrix metallopeptidase 28. (620 aa)
	MMP13	Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...] (472 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTSK	MMP1	ENSECAP00000016732	ENSECAP00000018911	Cathepsin K; Belongs to the peptidase C1 family.	Interstitial collagenase.	0.504
CTSK	MMP13	ENSECAP00000016732	ENSECAP00000005084	Cathepsin K; Belongs to the peptidase C1 family.	Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...]	0.730
CTSK	MMP3	ENSECAP00000016732	ENSECAP00000001652	Cathepsin K; Belongs to the peptidase C1 family.	Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase; Belongs to the peptidase M10A family.	0.527
CTSK	MMP7	ENSECAP00000016732	ENSECAP00000018750	Cathepsin K; Belongs to the peptidase C1 family.	Matrix metallopeptidase 7.	0.432
CTSK	MMP9	ENSECAP00000016732	ENSECAP00000011232	Cathepsin K; Belongs to the peptidase C1 family.	Matrix metallopeptidase 9.	0.707
CTSL	CTSS	ENSECAP00000043221	ENSECAP00000020156	Cathepsin L; Belongs to the peptidase C1 family.	Cathepsin S; Belongs to the peptidase C1 family.	0.950
CTSL	CTSV	ENSECAP00000043221	ENSECAP00000028148	Cathepsin L; Belongs to the peptidase C1 family.	Cathepsin V; Belongs to the peptidase C1 family.	0.902
CTSL	MMP13	ENSECAP00000043221	ENSECAP00000005084	Cathepsin L; Belongs to the peptidase C1 family.	Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...]	0.638
CTSL	MMP7	ENSECAP00000043221	ENSECAP00000018750	Cathepsin L; Belongs to the peptidase C1 family.	Matrix metallopeptidase 7.	0.680
CTSL	MMP9	ENSECAP00000043221	ENSECAP00000011232	Cathepsin L; Belongs to the peptidase C1 family.	Matrix metallopeptidase 9.	0.434
CTSS	CTSL	ENSECAP00000020156	ENSECAP00000043221	Cathepsin S; Belongs to the peptidase C1 family.	Cathepsin L; Belongs to the peptidase C1 family.	0.950
CTSS	CTSV	ENSECAP00000020156	ENSECAP00000028148	Cathepsin S; Belongs to the peptidase C1 family.	Cathepsin V; Belongs to the peptidase C1 family.	0.935
CTSS	MMP1	ENSECAP00000020156	ENSECAP00000018911	Cathepsin S; Belongs to the peptidase C1 family.	Interstitial collagenase.	0.423
CTSS	MMP13	ENSECAP00000020156	ENSECAP00000005084	Cathepsin S; Belongs to the peptidase C1 family.	Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...]	0.486
CTSS	MMP3	ENSECAP00000020156	ENSECAP00000001652	Cathepsin S; Belongs to the peptidase C1 family.	Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase; Belongs to the peptidase M10A family.	0.512
CTSS	MMP7	ENSECAP00000020156	ENSECAP00000018750	Cathepsin S; Belongs to the peptidase C1 family.	Matrix metallopeptidase 7.	0.514
CTSS	MMP9	ENSECAP00000020156	ENSECAP00000011232	Cathepsin S; Belongs to the peptidase C1 family.	Matrix metallopeptidase 9.	0.638
CTSV	CTSL	ENSECAP00000028148	ENSECAP00000043221	Cathepsin V; Belongs to the peptidase C1 family.	Cathepsin L; Belongs to the peptidase C1 family.	0.902
CTSV	CTSS	ENSECAP00000028148	ENSECAP00000020156	Cathepsin V; Belongs to the peptidase C1 family.	Cathepsin S; Belongs to the peptidase C1 family.	0.935
CTSV	MMP13	ENSECAP00000028148	ENSECAP00000005084	Cathepsin V; Belongs to the peptidase C1 family.	Collagenase 3; Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bon [...]	0.643